Biased Gs versus Gq proteins and ?-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network
(2015)
Journal Article
Valentin-Hansen, L., Frimurer, T. M., Mokrosinski, J., Holliday, N. D., & Schwartz, T. W. (2015). Biased Gs versus Gq proteins and ?-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network. Journal of Biological Chemistry, 290(40), 24495-24508. https://doi.org/10.1074/jbc.m115.641944
X-ray structures, molecular dynamics simulations, and mutational analysis have previously indicated that an extended water hydrogen bond network between trans-membranes I-III, VI, and VII constitutes an allosteric interface essential for stabilizing... Read More about Biased Gs versus Gq proteins and ?-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network.