All Outputs (52)

Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells (2020)
Journal Article
Chen, I. L., Todd, I., Tighe, P. J., & Fairclough, L. C. (2020). Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells. Archives of Toxicology, 94(6), 2097-2112 . https://doi.org/10.1007/s00204-020-02757-8

© 2020, The Author(s). Dendritic cells (DCs) are professional antigen presenting cells that play a critical role in bridging innate and adaptive immunity. Numerous studies have shown that tobacco constituents present in conventional cigarettes affect... Read More about Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells.

Extracellular vesicles and asthma: A review of the literature (2020)
Journal Article
Sangaphunchai, P., Todd, I., & Fairclough, L. C. (2020). Extracellular vesicles and asthma: A review of the literature. Clinical and Experimental Allergy, 50(3), 291-307. https://doi.org/10.1111/cea.13562

© 2020 John Wiley & Sons Ltd Asthma is a chronic, recurrent and incurable allergy-related respiratory disease characterized by inflammation, bronchial hyperresponsiveness and narrowing of the airways. Extracellular vesicles (EVs) are a universal fe... Read More about Extracellular vesicles and asthma: A review of the literature.

Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes (2019)
Journal Article
Nair, N., Hurley, M., Gates, S., Davies, P., Chen, I. L., Todd, I., …Bhatt, M. (2020). Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes. Archives of Disease in Childhood, 105(11), 1114-1116. https://doi.org/10.1136/archdischild-2019-317889

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. We report a case of hypersensitivity pneumonitis (HP) in a young person secondary to vaping. He presented with a putative diagnosis of asthma... Read More about Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes.

Mood and influenza vaccination in older adults: A randomized controlled trial. (2019)
Journal Article
Ayling, K., Fairclough, L., Buchanan, H., Wetherell, M. A., & Vedhara, K. (2019). Mood and influenza vaccination in older adults: A randomized controlled trial. Health Psychology, 38(11), 984-996. https://doi.org/10.1037/hea0000786

Objective: Positive mood on the day of vaccination has been associated with subsequent antibody responses to the influenza vaccine in older adults. The primary aim of this trial was to examine whether a brief intervention was able to enhance positive... Read More about Mood and influenza vaccination in older adults: A randomized controlled trial..

Towards a surrogate system to express human lipid binding TCRs (2019)
Journal Article
Wang, R., Pscheid, R., Ghumra, A., Kan, L. Y. L., Cochrane, S., Fairclough, L., & Alcocer, M. J. C. (2019). Towards a surrogate system to express human lipid binding TCRs. Biotechnology Letters, 41(10), 1095-1104. https://doi.org/10.1007/s10529-019-02713-2

Background Previously we reported that natural nut lipids were necessary for sensitization and that natural killer T cells (NKTs) must play a critical role in the development of food allergic responses. A major bottleneck in further understanding... Read More about Towards a surrogate system to express human lipid binding TCRs.

Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review (2019)
Journal Article
Tarbiah, N., Todd, I., Tighe, P. J., & Fairclough, L. C. (2019). Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review. Basic and Clinical Pharmacology and Toxicology, 125(5), 474-483. https://doi.org/10.1111/bcpt.13278

The aim of the present study was to compare concentrations of IgG, IgA, IgM and IgD in both serum and saliva samples from smoking and non-smoking subjects using a protein microarray assay. The findings were also compared to previous studies. Serum an... Read More about Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review.

Psychological interventions as vaccine adjuvants: A systematic review (2019)
Journal Article
Vedhara, K., Ayling, K., Sunger, K., Caldwell, D. M., Halliday, V., Fairclough, L., …Royal, S. (2019). Psychological interventions as vaccine adjuvants: A systematic review. Vaccine, 37(25), 3255-3266. https://doi.org/10.1016/j.vaccine.2019.04.091

Objectives: The effectiveness of vaccines is known to be altered by a range of psychological factors. We conducted a systematic review to evaluate the effects of psychological interventions on the ability of vaccines to protect against disease, as me... Read More about Psychological interventions as vaccine adjuvants: A systematic review.

Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation (2019)
Journal Article
Negm, O. H., Singh, S., Abduljabbar, W., Hamed, M. R., Radford, P., McDermott, E. M., …Tighe, P. J. (2019). Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation. Clinical and Experimental Immunology, 197(3), 352-360. https://doi.org/10.1111/cei.13306

Tumour necrosis factor receptor‐associated periodic syndrome (TRAPS) is an hereditary autoinflammatory disorder characterised by recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNFRSF1A, which encod... Read More about Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation.

Immunological and pathological effects of electronic cigarettes (2019)
Journal Article
Chen, I. L., Todd, I., & Fairclough, L. C. (2019). Immunological and pathological effects of electronic cigarettes. Basic and Clinical Pharmacology and Toxicology, 125(3), 237-252. https://doi.org/10.1111/bcpt.13225

© 2019 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Electronic cigarettes (E-cigarettes) are cons... Read More about Immunological and pathological effects of electronic cigarettes.

Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity (2019)
Journal Article
Holmes, J., Fairclough, L., & Todd, I. (2019). Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity. Archives of Dermatological Research, 311(3), 141-162. https://doi.org/10.1007/s00403-019-01890-4

Atopic dermatitis (AD) is a widespread condition that appears to be increasing in prevalence and severity worldwide, yet the underlying mechanisms are not well understood. Recent research has identified various similarities between AD and autoimmune... Read More about Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity.

Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells (2018)
Journal Article
Alkhattabi, N., Todd, I., Negm, O., Tighe, P. J., & Fairclough, L. C. (2018). Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells. Toxicology Letters, 299, 40-46. https://doi.org/10.1016/j.toxlet.2018.09.002

Cigarette smoke has significant toxic effects on the immune system, and increases the risk of developing autoimmune diseases; one immunosuppressive effect of cigarette smoke is that it inhibits the T cell-stimulating, immunogenic properties of myeloi... Read More about Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells.

Highly sensitive label-free antibody detection using a long period fibre grating sensor (2018)
Journal Article
Liu, L., Marques, L., Correia, R., Morgan, S. P., Lee, S., Tighe, P. J., …Korposh, S. (2018). Highly sensitive label-free antibody detection using a long period fibre grating sensor. Sensors and Actuators B: Chemical, 271, 24-32. https://doi.org/10.1016/j.snb.2018.05.109

An optical fibre long period grating (LPG) biosensor is appealing in the detection of biomolecules because of the high sensitivity, label-free and real-time measurement. The miniaturized size, ability of remote sensing and immunity to electromagnetic... Read More about Highly sensitive label-free antibody detection using a long period fibre grating sensor.

Measuring vaccine responses in the multiplex era (2018)
Book Chapter
Ayling, K., Vedhara, K., & Fairclough, L. (2018). Measuring vaccine responses in the multiplex era. In Q. Yan (Ed.), Psychoneuroimmunology: Methods and Protocols (327-340). (2nd). New York, USA: Springer Publishing Company. https://doi.org/10.1007/978-1-4939-7828-1_17

Vaccine studies in psychoneuroimmunology (PNI) provide an insight into biopsychosocial interactions and their role in infectious diseases. How to measure vaccine responses is therefore of critical importance for PNI researchers. In this chapter, trad... Read More about Measuring vaccine responses in the multiplex era.

Prophylactic antibiotic use in COPD and the potential anti-inflammatory activities of antibiotics (2018)
Journal Article
Huckle, A. W., Fairclough, L. C., & Todd, I. (2018). Prophylactic antibiotic use in COPD and the potential anti-inflammatory activities of antibiotics. Current Respiratory Care Reports, 63(5), https://doi.org/10.4187/respcare.05943

Antibiotics have previously demonstrated anti-inflammatory properties, and they have been linked to therapeutic benefit in several pulmonary conditions that feature inflammation. Previous research suggests that these anti-inflammatory properties may... Read More about Prophylactic antibiotic use in COPD and the potential anti-inflammatory activities of antibiotics.

Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885 (2018)
Journal Article
Shortall, S. E., Negm, O. H., Fowler, M., Fairclough, L. C., Tighe, P. J., Wigmore, P. M., & King, M. (2018). Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885. Molecular Neurobiology, 55(9), https://doi.org/10.1007/s12035-018-0940-0

Post-weaning social isolation of rats produces neuroanatomical, neurochemical and behavioral alterations resembling some core features of schizophrenia. This study examined the ability of the 5-HT? receptor antagonist SB-399885 to reverse isolation-i... Read More about Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885.

IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review (2017)
Journal Article
Hadjikyriacou Saniklidou, A., Tighe, P. J., Fairclough, L. C., & Todd, I. (in press). IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review. Archives of Dermatological Research, 310(1), https://doi.org/10.1007/s00403-017-1789-1

Bullous Pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type X... Read More about IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review.

Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease (2017)
Journal Article
Shindi, R., Al-Mehairi, A., Negm, O. H., Kalsheker, N., Gale, N., Shale, D. J., …Fairclough, L. C. (2017). Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease. Clinical Immunology, 183, https://doi.org/10.1016/j.clim.2017.09.020

Autoimmunity occurs in chronic obstructive pulmonary disease (COPD). We describe an antigen microarray for detecting serum autoantibodies (AAbs) to determine how IgM, as well as IgG, AAbs distinguish patients with COPD from controls with a history of... Read More about Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease.

Positive mood on the day of influenza vaccination predicts vaccine effectiveness: A prospective observational cohort study (2017)
Journal Article
Ayling, K., Fairclough, L., Tighe, P., Todd, I., Halliday, V., Garibaldi, J., …Vedhara, K. (2018). Positive mood on the day of influenza vaccination predicts vaccine effectiveness: A prospective observational cohort study. Brain, Behavior, and Immunity, 67, 314-323. https://doi.org/10.1016/j.bbi.2017.09.008

© 2017 Influenza vaccination is estimated to only be effective in 17–53% of older adults. Multiple patient behaviors and psychological factors have been shown to act as ‘immune modulators’ sufficient to influence vaccination outcomes. However, the re... Read More about Positive mood on the day of influenza vaccination predicts vaccine effectiveness: A prospective observational cohort study.

A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing (2017)
Journal Article
Figueredo, G., Todd, I., Negm, O. H., Reps, J., Radford, P., Figueredo, G. P., …Tighe, P. J. (2017). A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing. Pharmacological Research, 125, 188-200. https://doi.org/10.1016/j.phrs.2017.08.012

© 2017 Elsevier Ltd TNF receptor associated periodic syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways tha... Read More about A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing.

Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction (2016)
Journal Article
Tubby, C., Negm, O. H., Harrison, T. W., Tighe, P. J., Todd, I., & Fairclough, L. C. (2017). Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction. Journal of Asthma, 54(5), 456-466. https://doi.org/10.1080/02770903.2016.1236941

Objective: The three main types of killer cells – CD8+ T cells, NK cells and NKT cells – have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obs... Read More about Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction.