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All Outputs (35)

Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea (2018)
Journal Article
Laviola, M., Das, A., Chikhani, M., Bates, D., & Hardman, J. (2019). Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea. British Journal of Anaesthesia, 122(3), 395-401. https://doi.org/10.1016/j.bja.2018.11.012

Background Apnoeic oxygenation can come close to matching the oxygen demands of the apnoeic patient but does not facilitate carbon dioxide (CO2) elimination, potentially resulting in dangerous hypercapnia. Numerous studies have shown that high-flo... Read More about Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea.

Validity and reliability of an objective structured assessment tool for performance of ultrasound-guided regional anaesthesia (2018)
Journal Article
Shafqat, A., Rafi, M., Thanawala, V., Bedforth, N. M., Hardman, J., & McCahon, R. A. (2018). Validity and reliability of an objective structured assessment tool for performance of ultrasound-guided regional anaesthesia. British Journal of Anaesthesia, 121(4), 867-875. https://doi.org/10.1016/j.bja.2018.06.014

Background: We aimed to examine the validity and reliability of previously developed criterion-referenced assessment checklist (AC) and global rating scale (GRS) to assess performance in ultrasound-guided regional anaesthesia (UGRA). Methods: Twenty... Read More about Validity and reliability of an objective structured assessment tool for performance of ultrasound-guided regional anaesthesia.

Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., …Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, 3(4), 257-262. https://doi.org/10.1002/lio2.168

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More about Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score.

An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation (2018)
Journal Article
Saffaran, S., Wang, W., Das, A., Schmitt, W., Becker-Pelster, E., Hardman, J. G., …Bates, D. G. (2018). An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation. CPT: Pharmacometrics and Systems Pharmacology, 7(8), 491-498. https://doi.org/10.1002/psp4.12308

This study uses a highly fidelity computational simulator of pulmonary physiology to evaluate the impact of a soluble guanylate cyclase (sGC) modulator on gas exchange in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypert... Read More about An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation.

Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation (2017)
Conference Proceeding
Laviola, M., Das, A., Bates, D. G., & Hardman, J. G. (2017). Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (337-340). https://doi.org/10.1109/EMBC.2017.8036831

Gaseous mixing in the anatomical deadspace with stimulation of respiratory ventilation through cardiogenic oscillations is an important physiological mechanism at the onset of apnea, which has been credited with various beneficial effects, e.g. reduc... Read More about Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation.

Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome (2017)
Journal Article
Das, A., Haque, M., Chikhani, M., Cole, O., Wang, W., Hardman, J. G., & Bates, D. G. (2017). Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome. BMC Pulmonary Medicine, 17(34), https://doi.org/10.1186/s12890-017-0369-7

Background: Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poor... Read More about Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome.

High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery (2016)
Journal Article
Chikhani, M., Das, A., Haque, M., Wang, W., Bates, D., & Hardman, J. (2016). High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery. British Journal of Anaesthesia, 117(5), 650-658. https://doi.org/10.1093/bja/aew314

Background: Positive end-expiratory pressure (PEEP) is widely used to improve oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). While PEEP predictably improves arterial... Read More about High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery.

Characterization and use of a fiber optic sensor based on PAH/SiO2 film for humidity sensing in ventilator care equipment (2016)
Journal Article
Hernandez, F. U., Morgan, S. P., Hayes-Gill, B. R., Harvey, D., Kinnear, W., Norris, A., …Korposh, S. (2016). Characterization and use of a fiber optic sensor based on PAH/SiO2 film for humidity sensing in ventilator care equipment. IEEE Transactions on Biomedical Engineering, 63(9), 1985-1992. https://doi.org/10.1109/TBME.2016.2521662

Objective: To develop a compact probe that can be used to monitor humidity in ventilator care equipment. A mesoporous film of alternate layers of Poly(allylamine hydrochloride) (PAH) and silica (SiO2) nanoparticles (bilayers), deposited onto an optic... Read More about Characterization and use of a fiber optic sensor based on PAH/SiO2 film for humidity sensing in ventilator care equipment.

Visuospatial ability as a predictor of novice performance in ultrasound–guided regional anesthesia (2015)
Journal Article
Atif, S., Ferguson, E., Thanawala, V., Bedforth, N. M., Hardman, J., & McCahon, R. A. (2015). Visuospatial ability as a predictor of novice performance in ultrasound–guided regional anesthesia. Anesthesiology, 123(5), https://doi.org/10.1097/ALN.0000000000000870

Background: Visuospatial ability correlates positively with novice performance of simple laparoscopic tasks. The aims of this study were to identify if visuospatial ability could predict technical performance of an ultrasound–guided needle task by n... Read More about Visuospatial ability as a predictor of novice performance in ultrasound–guided regional anesthesia.

Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation (2015)
Journal Article
Das, A., Cole, O., Chikhani, M., Wang, W., Ali, T., Haque, M., …Hardman, J. G. (2015). Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation. Critical Care, 19, Article 8. https://doi.org/10.1186/s13054-014-0723-6

Introduction: Direct comparison of the relative efficacy of different recruitment maneuvers (RMs) for patients with acute respiratory distress syndrome (ARDS) via clinical trials is difficult, due to the heterogeneity of patient populations and disea... Read More about Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation.

Cadaveric study of movement of an unstable atlanto-axial (C1/C2) cervical segment during laryngoscopy and intubation using the Airtraq (R), Macintosh and McCoy laryngoscopes (2014)
Journal Article
McCahon, R., Evans, D., Kerslake, R., McClelland, S., Hardman, J., & Norris, A. (2015). Cadaveric study of movement of an unstable atlanto-axial (C1/C2) cervical segment during laryngoscopy and intubation using the Airtraq (R), Macintosh and McCoy laryngoscopes. Anaesthesia, 70(4), 452-461. doi:10.1111/anae.12956

Concern that laryngoscopy and intubation might create or exacerbate a spinal cord injury has generated extensive research into cervical spinal movement during laryngoscopy. We performed a randomised trial on six cadavers, using three different laryng... Read More about Cadaveric study of movement of an unstable atlanto-axial (C1/C2) cervical segment during laryngoscopy and intubation using the Airtraq (R), Macintosh and McCoy laryngoscopes.

Evaluation of the physiological properties of ventilatory ratio in a computational cardiopulmonary model and its clinical application in an acute respiratory distress syndrome population (2014)
Journal Article
Sinha, P., Hardman, J., Singh, S., Bersten, A. D., & Soni, N. C. (2014). Evaluation of the physiological properties of ventilatory ratio in a computational cardiopulmonary model and its clinical application in an acute respiratory distress syndrome population. British Journal of Anaesthesia, 112(1), 96-101. https://doi.org/10.1093/bja/aet283

Responsiveness of the EQ-5D health-related quality-of-life instrument in assessing low back pain (2013)
Journal Article
Whynes, D. K., McCahon, R. A., Ravenscroft, A., Hodgkinson, V., Evley, R., & Hardman, J. G. (2013). Responsiveness of the EQ-5D health-related quality-of-life instrument in assessing low back pain. Value in Health, 16(1), 124-132. https://doi.org/10.1016/j.jval.2012.09.003

Objective: To compare the responsiveness of the EuroQol five-dimensional questionnaire (EQ-5D) generic quality-of-life instrument with that of specific instruments - the Brief Pain Inventory (BPI) and the Oswestry Disability Index (ODI) - in assessin... Read More about Responsiveness of the EQ-5D health-related quality-of-life instrument in assessing low back pain.

Cost effectiveness of epidural steroid injections to manage chronic lower back pain (2012)
Journal Article
Whynes, D. K., McCahon, R. A., Ravenscroft, A., & Hardman, J. (2012). Cost effectiveness of epidural steroid injections to manage chronic lower back pain. BMC Anesthesiology, 12(26), Article 26. https://doi.org/10.1186/1471-2253-12-26

Background The efficacy of epidural steroid injections in the management of chronic low back pain is disputed, yet the technique remains popular amongst physicians and patients alike. This study assesses the cost effectiveness of injections administ... Read More about Cost effectiveness of epidural steroid injections to manage chronic lower back pain.