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Asia–Pacific association for study of liver guidelines on management of ascites in liver disease (2023)
Journal Article
Singh, V., De, A., Mehtani, R., Angeli, P., Maiwall, R., Satapathy, S., …Sarin, S. K. (2023). Asia–Pacific association for study of liver guidelines on management of ascites in liver disease. Hepatology International, 17(4), 792-826. https://doi.org/10.1007/s12072-023-10536-7

The development of ascites is a landmark event in the natural history of cirrhosis. This guidance statement by the Asia–Pacific Association for Study of Liver (APASL) provides an evidence-based approach to managing ascites and its complications in pa... Read More about Asia–Pacific association for study of liver guidelines on management of ascites in liver disease.

Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report (2023)
Journal Article
Andrade, R. J., Aithal, G. P., de Boer, Y. S., Liberal, R., Gerbes, A., Regev, A., …Björnsson, E. S. (in press). Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report. Journal of Hepatology, https://doi.org/10.1016/j.jhep.2023.04.033

Drug-induced liver injury (DILI) can mimic almost all other liver disorders. A phenotype increasingly ascribed to drugs is autoimmune-like hepatitis (ALH). This article summarises the major topics discussed at a joint International Conference held be... Read More about Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report.

Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease (2023)
Journal Article
Grove, J. I., Lo, P. C., Shrine, N., Barwell, J., Wain, L. V., Tobin, M. D., …Aithal, G. P. (2023). Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease. JHEP Reports, 5(8), Article 100764. https://doi.org/10.1016/j.jhepr.2023.100764

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a complex trait with an estimated prevalence of 25% globally. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, de... Read More about Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease.

Classifying the unclassifiable—a Delphi study to reach consensus on the fibrotic nature of diseases (2023)
Journal Article
Massen, G. M., Allen, R. J., Leavy, O. C., Selby, N. M., Aithal, G. P., Oliver, N., …Quint, J. K. (2023). Classifying the unclassifiable—a Delphi study to reach consensus on the fibrotic nature of diseases. QJM: An International Journal of Medicine, 116(6), 429-435. https://doi.org/10.1093/qjmed/hcad050

BACKGROUND: Traditionally, clinical research has focused on individual fibrotic diseases or fibrosis in a particular organ. However, it is possible for people to have multiple fibrotic diseases. While multi-organ fibrosis may suggest shared pathogeni... Read More about Classifying the unclassifiable—a Delphi study to reach consensus on the fibrotic nature of diseases.

Machine learning algorithm improves the detection of NASH (NAS-based) and at-risk NASH: A development and validation study (2023)
Journal Article
Lee, J., Westphal, M., Vali, Y., Boursier, J., Ostroff, R., Alexander, L., …LITMUS investigators, L. I. (2023). Machine learning algorithm improves the detection of NASH (NAS-based) and at-risk NASH: A development and validation study. Hepatology, 78(1), 258-271. https://doi.org/10.1097/HEP.0000000000000364

Background and Aims: Detecting NASH remains challenging, while at-risk NASH (steatohepatitis and F≥ 2) tends to progress and is of interest for drug development and clinical application. We developed prediction models by supervised machine learning t... Read More about Machine learning algorithm improves the detection of NASH (NAS-based) and at-risk NASH: A development and validation study.

Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study (2023)
Journal Article
Vali, Y., Lee, J., Boursier, J., Petta, S., Wonders, K., Tiniakos, D., …Bossuyt, P. M. (2023). Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study. The Lancet Gastroenterology & Hepatology, 8(8), 714-725. https://doi.org/10.1016/S2468-1253%2823%2900017-1

Background: The reference standard for detecting non-alcoholic steatohepatitis (NASH) and staging fibrosis—liver biopsy—is invasive and resource intensive. Non-invasive biomarkers are urgently needed, but few studies have compared these biomarkers in... Read More about Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study.

Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (2023)
Journal Article
Pennisi, G., Enea, M., Falco, V., Aithal, G. P., Palaniyappan, N., Yilmaz, Y., …Petta, S. (2023). Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Hepatology, 78(1), 195-211. https://doi.org/10.1097/HEP.0000000000000351

Background and Aims: We evaluated the diagnostic accuracy of simple, noninvasive tests (NITs) in NAFLD patients with type 2 diabetes (T2D). Methods and Results: This was an individual patient data meta-analysis of 1780 patients with biopsy-proven NAF... Read More about Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes.

Circulating leukocyte cell-derived chemotaxin 2 and fibroblast growth factor 21 are negatively associated with cardiorespiratory fitness in healthy volunteers (2023)
Journal Article
Malaikah, S., Willis, S. A., Henson, J., Sargeant, J. A., Yates, T., Thackray, A. E., …King, J. A. (2023). Circulating leukocyte cell-derived chemotaxin 2 and fibroblast growth factor 21 are negatively associated with cardiorespiratory fitness in healthy volunteers. Applied Physiology, Nutrition, and Metabolism, 48(6), 436-444. https://doi.org/10.1139/apnm-2022-0445

Leukocyte cell-derived chemotaxin-2 (LECT2) and fibroblast growth factor 21 (FGF21) are hepatokines that are regulated by energy balance and mediate insulin sensitivity and glycaemic control. This cross-sectional study examined the independent associ... Read More about Circulating leukocyte cell-derived chemotaxin 2 and fibroblast growth factor 21 are negatively associated with cardiorespiratory fitness in healthy volunteers.

Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans (2023)
Journal Article
Ravindra, K. C., Vaidya, V. S., Wang, Z., Federspiel, J. D., Virgen-Slane, R., Everley, R. A., …Ramaiah, S. K. (2023). Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans. Nature Communications, 14, Article 1215. https://doi.org/10.1038/s41467-023-36858-6

Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of c... Read More about Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.

Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study (2023)
Journal Article
Mehta, O., Vijay, A., Gohir, S. A., Kelly, T., Zhang, W., Doherty, M., …Valdes, A. M. (2023). Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study. Journal of Pain, https://doi.org/10.1016/j.jpain.2023.02.023

Osteoarthritis (OA) is the most common arthritis affecting synovial joints such as knees and hips of millions of people globally. Usage-related joint pain and reduced function are the most common symptoms experienced by people with OA. To improve pai... Read More about Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study.

Textbook Outcome After Trans-arterial Chemoembolization for Hepatocellular Carcinoma (2023)
Journal Article
Mosconi, C., O'Rourke, J., Kloeckner, R., Sturm, L., Golfieri, R., Celsa, C., …Cucchetti, A. (2023). Textbook Outcome After Trans-arterial Chemoembolization for Hepatocellular Carcinoma. CardioVascular and Interventional Radiology, 46, 449-459. https://doi.org/10.1007/s00270-023-03375-4

Purpose Textbook Outcome (TO) is inclusive of quality indicators and it not been provided for trans-arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Materials and Methods Data on treatment-naïve HCC patients receiving TACE... Read More about Textbook Outcome After Trans-arterial Chemoembolization for Hepatocellular Carcinoma.

Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy (2023)
Working Paper
Astbury, S., Baskar, A., Grove, J. I., Kaye, P., Aravinthan, A. D., James, M. W., …Venkatachalapathy, S. V. Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy

Background and study aims Pancreatic cysts are common incidental findings, with an estimated prevalence of 13-15% in imaging done for other reasons. It is difficult to identify cysts with malignant potential. Diagnosis often relies on collection of c... Read More about Next-generation sequencing of pancreatic cyst wall specimens obtained using Moray micro-forceps for improving diagnostic accuracy.

A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men (2023)
Journal Article
Aliyu, A. I., Nixon, A., Hoad, C., Marciani, L., Corsetti, M., Aithal, G. P., …Taylor, M. A. (2023). A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men. British Journal of Nutrition, 130(8), 1316-1328. https://doi.org/10.1017/S0007114523000302

AbstractInclusion in nasogastric tube feeds (NGTF) of acid-sensitive, seaweed-derived alginate, expected to form a reversible gel in the stomach, may create a more normal intragastric state and modified gastrointestinal responses. This may ameliorate... Read More about A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men.

Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury (2023)
Journal Article
Gai, Z., Samodelov, S. L., Alecu, I., Hornemann, T., Grove, J. I., Aithal, G. P., …Kullak-Ublick, G. A. (2023). Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury. International Journal of Molecular Sciences, 24(3), Article 3013. https://doi.org/10.3390/ijms24033013

Sphingolipids are exceptionally diverse, comprising hundreds of unique species. The bulk of circulating sphingolipids are synthesized in the liver, thereby plasma sphingolipid profiles represent reliable surrogates of hepatic sphingolipid metabolism... Read More about Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury.

Extra‐hepatic Morbidity and Mortality in Alcohol‐related Liver Disease: Systematic Review and Meta‐analysis (2023)
Journal Article
Theodoreson, M. D., Aithal, G. P., Allison, M., Brahmania, M., Forrest, E., Hagström, H., …Parker, R. (2023). Extra‐hepatic Morbidity and Mortality in Alcohol‐related Liver Disease: Systematic Review and Meta‐analysis. Liver International, 43(4), 763-772. https://doi.org/10.1111/liv.15526

Background Alcohol use increases the risk of many conditions in addition to liver disease; patients with alcohol-related liver disease (ALD) are therefore at risk from both extra-hepatic and hepatic disease. Aims This review synthesises informat... Read More about Extra‐hepatic Morbidity and Mortality in Alcohol‐related Liver Disease: Systematic Review and Meta‐analysis.

Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated (2023)
Journal Article
Atallah, E., Grove, J., Crooks, C., Burden-Teh, E., Abhishek, A., Moreea, S., …Aithal, G. (2023). Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated. Journal of Hepatology, 78(5), 989-997. https://doi.org/10.1016/j.jhep.2022.12.034

Background & Aims The risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated at around 5%, prompting intensive monitoring strategies. However, the evidence is derived from retrospective studies that under-re... Read More about Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated.

Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated (2023)
Journal Article
Atallah, E., Grove, J. I., Crooks, C., Burden-Teh, E., Abhishek, A., Moreea, S., …Aithal, G. P. (2023). Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated. Journal of Hepatology, 78(5), 989-997. https://doi.org/10.1016/j.jhep.2022.12.034

Background & Aims: The risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated at around 5%, prompting intensive monitoring strategies. However, the evidence is derived from retrospective studies that under-re... Read More about Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated.

The effect of acute and chronic exercise on hepatic lipid composition (2023)
Journal Article
Willis, S. A., Malaikah, S., Parry, S., Bawden, S., Ennequin, G., Sargeant, J. A., …King, J. A. (2023). The effect of acute and chronic exercise on hepatic lipid composition. Scandinavian Journal of Medicine and Science in Sports, 33(5), 550-568. https://doi.org/10.1111/sms.14310

Exercise is recommended for those with, or at risk of nonalcoholic fatty liver disease (NAFLD), owing to beneficial effects on hepatic steatosis and cardiometabolic risk. Whilst exercise training reduces total intrahepatic lipid in people with NAFLD,... Read More about The effect of acute and chronic exercise on hepatic lipid composition.