All Outputs (59)

Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients (2021)
Journal Article
Jewell, A., Williams, H., Hoad, C. L., Gellert, P. R., Ashford, M. B., Butler, J., …Gershkovich, P. (2021). Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients. Pharmaceutics, 13(9), Article 1343. https://doi.org/10.3390/pharmaceutics13091343

Dietary lipids and some pharmaceutical lipid excipients can facilitate the targeted delivery of drugs to the intestinal lymphatics. Here, the feasibility of magnetic resonance imaging (MRI) for imaging lipid uptake into the intestinal lymphatics was... Read More about Assessing lymphatic uptake of lipids using magnetic resonance imaging: A feasibility study in healthy human volunteers with potential application for tracking lymph node delivery of drugs and formulation excipients.

Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging (2021)
Journal Article
Abouselo, A., Rance, G. A., Tres, F., Taylor, L. S., Kwokal, A., Renou, L., …Aylott, J. W. (2021). Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging. Molecular Pharmaceutics, 18(9), 3247-3259. https://doi.org/10.1021/acs.molpharmaceut.1c00119

We have employed a bespoke setup combining confocal Raman microscopy and an ultraviolet–visible (UV–Vis) spectroscopy flow cell to investigate the effect of excipients on the disproportionation kinetics of Pioglitazone HCl (PioHCl) in tablets during... Read More about Effect of Excipients on Salt Disproportionation during Dissolution: A Novel Application of In Situ Raman Imaging.

Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles (2021)
Journal Article
Trindade, G. F., Wang, F., Im, J., He, Y., Balogh, A., Scurr, D., …Roberts, C. J. (2021). Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles. Communications Materials, 2(1), Article 47. https://doi.org/10.1038/s43246-021-00151-0

Inkjet printing of metal nanoparticles allows for design flexibility, rapid processing and enables the 3D printing of functional electronic devices through co-deposition of multiple materials. However, the performance of printed devices, especially t... Read More about Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles.

Sequential Orbitrap Secondary Ion Mass Spectrometry and Liquid Extraction Surface Analysis-Tandem Mass Spectrometry-Based Metabolomics for Prediction of Brain Tumor Relapse from Sample-Limited Primary Tissue Archives (2021)
Journal Article
Meurs, J., Scurr, D. J., Lourdusamy, A., Storer, L. C., Grundy, R. G., Alexander, M. R., …Kim, D. (2021). Sequential Orbitrap Secondary Ion Mass Spectrometry and Liquid Extraction Surface Analysis-Tandem Mass Spectrometry-Based Metabolomics for Prediction of Brain Tumor Relapse from Sample-Limited Primary Tissue Archives. Analytical Chemistry, 93(18), 6947-6954. https://doi.org/10.1021/acs.analchem.0c05087

We present here a novel surface mass spectrometry strategy to perform untargeted metabolite profiling of formalin-fixed paraffin-embedded pediatric ependymoma archives. Sequential Orbitrap secondary ion mass spectrometry (3D OrbiSIMS) and liquid extr... Read More about Sequential Orbitrap Secondary Ion Mass Spectrometry and Liquid Extraction Surface Analysis-Tandem Mass Spectrometry-Based Metabolomics for Prediction of Brain Tumor Relapse from Sample-Limited Primary Tissue Archives.

Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling (2020)
Journal Article
Kotowska, A. M., Trindade, G. F., Mendes, P. M., Williams, P. M., Aylott, J. W., Shard, A. G., …Scurr, D. J. (2020). Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling. Nature Communications, 11(1), Article 5832. https://doi.org/10.1038/s41467-020-19445-x

Label-free protein characterization at surfaces is commonly achieved using digestion and/or matrix application prior to mass spectrometry. We report the assignment of undigested proteins at surfaces in situ using secondary ion mass spectrometry (SIMS... Read More about Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling.

Spatially Resolved Molecular Compositions of Insoluble Multilayer Deposits Responsible for Increased Pollution from Internal Combustion Engines (2020)
Journal Article
Edney, M. K., Lamb, J. S., Spanu, M., Smith, E. F., Steer, E., Wilmot, E., …Scurr, D. J. (2020). Spatially Resolved Molecular Compositions of Insoluble Multilayer Deposits Responsible for Increased Pollution from Internal Combustion Engines. ACS Applied Materials and Interfaces, 12(45), 51026-51035. https://doi.org/10.1021/acsami.0c14532

Internal combustion engines are used heavily in diverse applications worldwide. Achieving the most efficient operation is key to improving air quality as society moves to a decarbonized energy system. Insoluble deposits that form within internal comb... Read More about Spatially Resolved Molecular Compositions of Insoluble Multilayer Deposits Responsible for Increased Pollution from Internal Combustion Engines.

Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma (2020)
Journal Article
Sabri, A. H., Cater, Z., Gurnani, P., Ogilvie, J., Segal, J., Scurr, D. J., & Marlow, M. (2020). Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma. International Journal of Pharmaceutics, 589, Article 119808. https://doi.org/10.1016/j.ijpharm.2020.119808

Despite being one of the most efficacious drugs used in the treatment of basal cell carcinoma (BCC), imiquimod has limited cutaneous permeation. The current work presents the development of polyvinylpyrrolidone-co-vinyl acetate (PVPVA) microneedles l... Read More about Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma.

Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules (2020)
Journal Article
Sabri, A., Ogilvie, J., McKenna, J., Segal, J., Scurr, D., & Marlow, M. (2020). Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules. Molecular Pharmaceutics, 17(8), 2925–2937. https://doi.org/10.1021/acs.molpharmaceut.0c00347

Basal cell carcinoma (BCC) is the most common cutaneous malignancy in humans. One of the most efficacious drugs used in the management of BCC is the immunomodulator, imiquimod. However, imiquimod has physiochemical properties that limit its permeatio... Read More about Intradermal Delivery of an Immunomodulator for Basal Cell Carcinoma; Expanding the Mechanistic Insight into Solid Microneedle-Enhanced Delivery of Hydrophobic Molecules.

Characterisation of mechanical insertion of commercial microneedles (2020)
Journal Article
Sabri, A. H., Cater, Z., Ogilvie, J., Scurr, D. J., Marlow, M., & Segal, J. (2020). Characterisation of mechanical insertion of commercial microneedles. Journal of Drug Delivery Science and Technology, 58, https://doi.org/10.1016/j.jddst.2020.101766

The protection provided by the human skin is mostly attributed to the stratum corneum. However, this barrier also limits the range of molecules that can be delivered into and across the skin. One of the methods to overcome this physiological barrier... Read More about Characterisation of mechanical insertion of commercial microneedles.

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation (2020)
Journal Article
Vassey, M. J., Figueredo, G. P., Scurr, D. J., Vasilevich, A. S., Vermeulen, S., Carlier, A., …Alexander, M. R. (2020). Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation. Advanced Science, 7(11), https://doi.org/10.1002/advs.201903392

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Macrophages play a central role in orchestrating immune responses to foreign materials, which are often responsible for the failure of implanted medical devices. Material t... Read More about Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation.

Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery (2019)
Journal Article
Breen, A. F., Scurr, D., Cassioli, M. L., Wells, G., Thomas, N. R., Zhang, J., …Bradshaw, T. D. (2019). Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery. International Journal of Nanomedicine, 14, 9525-9534. https://doi.org/10.2147/IJN.S226293

Introduction: Advancment of novel anticancer drugs into clinic is frequently halted by their lack of solubility, reduced stability under physiological conditions, and non-specific uptake by normal tissues, causing systemic toxicity. Their progress to... Read More about Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery.

Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling (2019)
Journal Article
Starr, N. J., Hamid, K. A., Wibawa, J., Marlow, I., Bell, M., Pérez-García, L., …Scurr, D. J. (2019). Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling. International Journal of Pharmaceutics, 563, 21-29. https://doi.org/10.1016/j.ijpharm.2019.03.028

Vitamin C (ascorbic acid) is a naturally occurring, powerful anti-oxidant with the potential to deliver numerous benefits to the skin when applied topically. However, topical use of this compound is currently restricted by an instability in tradition... Read More about Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling.

Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment (2019)
Journal Article
Al-Mayahy, M. H., Sabri, A. H., Rutland, C. S., Holmes, A., McKenna, J., Marlow, M., & Scurr, D. J. (2019). Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment. European Journal of Pharmaceutics and Biopharmaceutics, 139, 33-43. https://doi.org/10.1016/j.ejpb.2019.02.006

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only li... Read More about Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment.

Reversible, High-Affinity Surface Capturing of Proteins Directed by Supramolecular Assembly (2019)
Journal Article
Di Palma, G., Kotowska, A. M., Hart, L. R., Scurr, D. J., Rawson, F. J., Tommasone, S., & Mendes, P. M. (2019). Reversible, High-Affinity Surface Capturing of Proteins Directed by Supramolecular Assembly. ACS Applied Materials and Interfaces, 11(9), 8937-8944. https://doi.org/10.1021/acsami.9b00927

The ability to design surfaces with reversible, high-affinity protein binding sites represents a significant step forward in the advancement of analytical methods for diverse biochemical and biomedical applications. Herein, we report a dynamic supram... Read More about Reversible, High-Affinity Surface Capturing of Proteins Directed by Supramolecular Assembly.

The physicochemical fingerprint of Necator americanus (2017)
Journal Article
Chauhan, V. M., Scurr, D. J., Christie, T., Telford, G., Aylott, J. W., & Pritchard, D. (in press). The physicochemical fingerprint of Necator americanus. PLoS Neglected Tropical Diseases, 11(12), Article e0005971. https://doi.org/10.1371/journal.pntd.0005971

Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world’s population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs... Read More about The physicochemical fingerprint of Necator americanus.

On the suitability of high vacuum electrospray deposition for the fabrication of molecular electronic devices (2017)
Journal Article
Temperton, R. H., O'Shea, J. N., & Scurr, D. J. (2017). On the suitability of high vacuum electrospray deposition for the fabrication of molecular electronic devices. Chemical Physics Letters, 682, 15-19. https://doi.org/10.1016/j.cplett.2017.05.068

© 2017 We present a series of three studies investigating the potential application of high vacuum electrospray deposition to construct molecular electronic devices. Through the use of time of flight secondary ion mass spectrometry we explore the use... Read More about On the suitability of high vacuum electrospray deposition for the fabrication of molecular electronic devices.

Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology (2017)
Journal Article
Taresco, V., Louzao, I., Scurr, D. J., Turpin, E. R., Laughton, C. A., Alexander, C., …Garnett, M. (in press). Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology. Molecular Pharmaceutics, 14(6), https://doi.org/10.1021/acs.molpharmaceut.7b00182

A miniaturized, high-throughput assay was optimized to screen polymer-drug solid dispersions using a 2-D Ink-jet printer. By simply printing nanoliter amounts of polymer and drug solutions onto an inert surface, drug:polymer micro-dots of tunable com... Read More about Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology.

Tailoring the electrochemical properties of carbon nanotube modified indium tin oxide via in situ grafting of aryl diazonium (2017)
Journal Article
Wong, Z. Y., Scurr, D. J., Silman, N., Jackson, S. K., Mendes, P. M., Aylott, J. W., …Hicks, J. (2017). Tailoring the electrochemical properties of carbon nanotube modified indium tin oxide via in situ grafting of aryl diazonium. Langmuir, 33(20), 4924-4933. https://doi.org/10.1021/acs.langmuir.7b00494

Our ability to tailor the electronic properties of surfaces by nanomodification is paramount for various applications, including development of sensing, fuel cell, and solar technologies. Moreover, in order to improve the rational design of conductin... Read More about Tailoring the electrochemical properties of carbon nanotube modified indium tin oxide via in situ grafting of aryl diazonium.

Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: characterisation by in vitro percutaneous absorption studies and time-of-flight secondary ion mass spectrometry (2017)
Journal Article
Holmes, A. M., Scurr, D. J., Heylings, J. R., Wan, K., & Moss, G. P. (2017). Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: characterisation by in vitro percutaneous absorption studies and time-of-flight secondary ion mass spectrometry. European Journal of Pharmaceutical Sciences, 104, https://doi.org/10.1016/j.ejps.2017.03.034

Skin penetration and localisation of chlorhexidine digluconate (CHG) within the skin have been investigated in order to better understand and optimise the delivery using a nano polymeric delivery system of this topically-applied antimicrobial drug. F... Read More about Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: characterisation by in vitro percutaneous absorption studies and time-of-flight secondary ion mass spectrometry.

Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis (2017)
Journal Article
Dereymaker, A., Scurr, D. J., Steer, E. D., Roberts, C. J., & Van den Mooter, G. (2017). Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis. Molecular Pharmaceutics, 14(4), 959-973. https://doi.org/10.1021/acs.molpharmaceut.6b01023

Fluid bed coating has been shown to be a suitable manufacturing technique to formulate poorly soluble drugs in glass solutions. Layering inert carriers with a drug–polymer mixture enables these beads to be immediately filled into capsules, thus avoid... Read More about Controlling the release of indomethacin from glass solutions layered with a rate controlling membrane using fluid-bed processing. Part 1: Surface and cross-sectional chemical analysis.