All Outputs (25)

Mechanism of mucosal permeability enhancement of CriticalSorb® (Solutol® HS15) investigated in vitro in cell cultures (2014)
Journal Article
Shubber, S., Vllasaliu, D., Rauch, C., Jordan, F., Illum, L., & Stolnik-Trenkic, S. (2015). Mechanism of mucosal permeability enhancement of CriticalSorb® (Solutol® HS15) investigated in vitro in cell cultures. Pharmaceutical Research, 32(2), 516-527. https://doi.org/10.1007/s11095-014-1481-5

Purpose: CriticalSorb™, with the principal component Solutol® HS15, is a novel mucosal drug delivery system demonstrated to improve the bioavailability of selected biotherapeutics. The intention of this study is to elucidate mechanism(s) responsible... Read More about Mechanism of mucosal permeability enhancement of CriticalSorb® (Solutol® HS15) investigated in vitro in cell cultures.

Impact of maternal dietary fat supplementation during gestation upon skeletal muscle in neonatal pigs (2014)
Journal Article
Fainberg, H., Almond, K., Rauch, C., Li, D., Bikker, P., Symonds, M., & Mostyn, A. (2014). Impact of maternal dietary fat supplementation during gestation upon skeletal muscle in neonatal pigs. BMC Physiology, 14, 1-12. https://doi.org/10.1186/s12899-014-0006-0

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer (2013)
Journal Article
Daniel, C., Bell, C., Burton, C., Harguindey, S., Reshkinc, S. J., & Rauch, C. (2013). The role of proton dynamics in the development and maintenance of multidrug resistance in cancer. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1832(5), https://doi.org/10.1016/j.bbadis.2013.01.020

With a projected 382.4 per 100,000 people expected to suffer from some form of malignant neoplasm in 2015, improving treatment is an essential focus of cancer research today. Multi-drug resistance (MDR) is the leading cause of chemotherapeutic failur... Read More about The role of proton dynamics in the development and maintenance of multidrug resistance in cancer.

Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti-cancer therapy (2013)
Journal Article
Rauch, C., Ibrahim, H., & Foster, N. (2013). Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti-cancer therapy. Journal of cancer therapeutics & research, 2, Article 20. https://doi.org/10.7243/2049-7962-2-20

Despite great medical advancement in the treatment of cancer, cancer remains a disease of global significance. Chemotherapeutics can be very expensive and drain medical resources at a national level and in some cases the cost of treatment is so great... Read More about Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti-cancer therapy.

On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry (2012)
Journal Article
Pang, V., Counillon, L., Lagadic-Gossmann, D., Poet, M., Lacroix, J., Sergent, O., …Rauch, C. (2012). On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry. Cell Biochemistry and Biophysics, 63(1), https://doi.org/10.1007/s12013-012-9340-7

The sodium-proton exchanger 1 (NHE-1) is a membrane transporter that exchanges Na+ for H+ ion across the membrane of eukaryotic cells. It is cooperatively activated by intracellular protons, and this allosteric regulation is modulated by the biophysi... Read More about On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry.