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Quinones as Dienophiles in the Diels-Alder Reaction: History and Applications in Total Synthesis (2014)
Journal Article
Nawrat, C. C., & Moody, C. J. (2014). Quinones as Dienophiles in the Diels-Alder Reaction: History and Applications in Total Synthesis. Angewandte Chemie International Edition, 53(8), 2056-2077. https://doi.org/10.1002/anie.201305908

In the canon of reactions available to the organic chemist engaged in total synthesis, the Diels–Alder reaction is among the most powerful and well understood. Its ability to rapidly generate molecular complexity through the simultaneous formation of... Read More about Quinones as Dienophiles in the Diels-Alder Reaction: History and Applications in Total Synthesis.

Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90 (2014)
Journal Article
Dutton, B. L., Kitson, R. R., Parry-Morris, S., Roe, S. M., Prodromou, C., & Moody, C. J. (2014). Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Organic and Biomolecular Chemistry, 12(8), https://doi.org/10.1039/C3OB42211A

A series of macrolactam analogues of the naturally occurring resorcylic acid lactone radicicol have been synthesised from methyl orsellinate in 7 steps, involving chlorination, protection of the two phenolic groups, and hydrolysis to the benzoic acid... Read More about Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90.

Synthesis of toxyloxanthone B (2014)
Journal Article
Giallombardoa, D., Nevin, A. C., Lewis, W., Nawrat, C. C., Kitson, R. R., & Moody, C. J. (2014). Synthesis of toxyloxanthone B. Tetrahedron, 70(6), https://doi.org/10.1016/j.tet.2013.12.055

A synthesis of the naturally occurring xanthone toxyloxanthone B is described, in which the key step is the regioselective addition of a methyl salicylate to a substituted benzyne followed by cyclization of the intermediate aryl anion to form the xan... Read More about Synthesis of toxyloxanthone B.

Copper(II)-mediated synthesis of indolequinones from bromoquinones and enamines (2013)
Journal Article
Inman, M., & Moody, C. J. (2013). Copper(II)-mediated synthesis of indolequinones from bromoquinones and enamines. European Journal of Organic Chemistry, 2013(11), https://doi.org/10.1002/ejoc.201201597

The reaction of enamines and bromoquinones in the presence of copper(II) acetate and potassium carbonate results in a regiospecific synthesis of indolequinones. The reaction is broad in scope and scalable and provides a route to the core structure th... Read More about Copper(II)-mediated synthesis of indolequinones from bromoquinones and enamines.