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All Outputs (14)

Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts (2024)
Journal Article
Caulton, S. G., Lambert, C., Tyson, J., Radford, P., Al-Bayati, A., Greenwood, S., …Lovering, A. L. (2024). Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts. Nature Microbiology, 9(1), 214-227. https://doi.org/10.1038/s41564-023-01552-2

Predatory bacteria, like the model endoperiplasmic bacterium Bdellovibrio bacteriovorus, show several adaptations relevant to their requirements for locating, entering and killing other bacteria. The mechanisms underlying prey recognition and handlin... Read More about Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts.

Production of 3′,3′-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility (2022)
Journal Article
Lowry, R. C., Hallberg, Z. F., Till, R., Simons, T. J., Nottingham, R., Want, F., …Lambert, C. (2022). Production of 3′,3′-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility. PLoS Genetics, 18(5), Article e1010164. https://doi.org/10.1371/journal.pgen.1010164

Bacterial second messengers are important for regulating diverse bacterial lifestyles. Cyclic di-GMP (c-di-GMP) is produced by diguanylate cyclase enzymes, named GGDEF proteins, which are widespread across bacteria. Recently, hybrid promiscuous (Hypr... Read More about Production of 3′,3′-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility.

A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorus (2020)
Journal Article
Harding, C. J., Huwiler, S. G., Somers, H., Lambert, C., Ray, L. J., Till, R., …Lovering, A. L. (2020). A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorus. Nature Communications, 11, Article 4817. https://doi.org/10.1038/s41467-020-18139-8

Lysozymes are among the best-characterized enzymes, acting upon the cell wall substrate peptidoglycan. Here, examining the invasive bacterial periplasmic predator Bdellovibrio bacteriovorus, we report a diversified lysozyme, DslA, which acts, unusual... Read More about A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorus.

Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot (2020)
Journal Article
Hobley, L., Summers, J. K., Till, R., Milner, D. S., Atterbury, R. J., Stroud, A., …Sockett, R. E. (2020). Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot. Journal of Bacteriology, 202(6), Article e00629-19. https://doi.org/10.1128/JB.00629-19

Copyright © 2020 Hobley et al. Bacteria are preyed upon by diverse microbial predators, including bacteriophage and predatory bacteria, such as Bdellovibrio bacteriovorus. While bacteriophage are used as antimicrobial therapies in Eastern Europe and... Read More about Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot.

Nucleotide signaling pathway convergence in a cAMP?sensing bacterial c?di?GMP phosphodiesterase (2019)
Journal Article
Cadby, I. T., Basford, S. M., Nottingham, R., Meek, R., Lowry, R., Lambert, C., …Lovering, A. L. (2019). Nucleotide signaling pathway convergence in a cAMP‐sensing bacterial c‐di‐GMP phosphodiesterase. EMBO Journal, 38(17), Article e100772. https://doi.org/10.15252/embj.2018100772

Bacterial usage of the cyclic dinucleotide c-di-GMP is widespread, governing the transition between motile/sessile and unicellular/ multicellular behaviors. There is limited information on c-di-GMP metabolism, particularly on regulatory mechanisms go... Read More about Nucleotide signaling pathway convergence in a cAMP?sensing bacterial c?di?GMP phosphodiesterase.

Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential (2019)
Journal Article
Raghunathan, D., Radford, P. M., Gell, C., Negus, D., Moore, C., Till, R., …Tyson, J. (2019). Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential. Scientific Reports, 9, 1-16. https://doi.org/10.1038/s41598-019-40223-3

In assessing the potential of predatory bacteria, such as Bdellovibrio bacteriovorus, to become live therapeutic agents against bacterial infections, it is crucial to understand and quantify Bdellovibrio host cell interactions at a molecular level. H... Read More about Engulfment, persistance and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential.

Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation (2017)
Journal Article
Kuru, E., Lambert, C., Jonathon, R., Till, R., Ducret, A., Derouaux, A., …Sockett, L. (2017). Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation. Nature Microbiology, 2(12), 1648-1657. https://doi.org/10.1038/s41564-017-0029-y

Modification of essential bacterial peptidoglycan (PG) containing cell walls can lead to antibiotic resistance, for example ?-lactam resistance by L,D-transpeptidase activities. Predatory Bdellovibrio bacteriovorus are naturally antibacterial and com... Read More about Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation.

Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae (2016)
Journal Article
Willis, A. R., Moore, C., Mazon-Moya, M., Krokowski, S., Lambert, C., Till, R., …Sockett, R. E. (2016). Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae. Current Biology, 26(24), 3343-3351. https://doi.org/10.1016/j.cub.2016.09.067

Bdellovibrio bacteriovorus are predatory bacteria that invade and kill a range of Gram-negative bacterial pathogens in natural environments and in vitro [ 1 and 2]. In this study, we investigated Bdellovibrio as an injected, antibacterial treatment i... Read More about Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae.

Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus (2015)
Journal Article
Lambert, C., Cadby, I. T., Till, R., Bui, N. K., Lerner, T. R., Hughes, W. S., …Lovering, A. L. (2015). Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus. Nature Communications, 6, Article 8884. https://doi.org/10.1038/ncomms9884

Predatory Bdellovibrio bacteriovorus are natural antimicrobial organisms, killing other bacteria by whole-cell invasion. Self-protection against prey-metabolizing enzymes is important for the evolution of predation. Initial prey entry involves the pr... Read More about Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus.

Ras GTPase-like protein MglA, a controller of bacterial social-motility in Myxobacteria, has evolved to control bacterial predation by Bdellovibrio (2014)
Journal Article
Milner, D. S., Till, R., Cadby, I., Lovering, A. L., Basford, S. M., Saxon, E. B., …Sockett, R. E. (2014). Ras GTPase-like protein MglA, a controller of bacterial social-motility in Myxobacteria, has evolved to control bacterial predation by Bdellovibrio. PLoS Genetics, 10(4), Article e1004253. https://doi.org/10.1371/journal.pgen.1004253

Bdellovibrio bacteriovorus invade Gram-negative bacteria in a predatory process requiring Type IV pili (T4P) at a single invasive pole, and also glide on surfaces to locate prey. Ras-like G-protein MglA, working with MglB and RomR in the deltaproteob... Read More about Ras GTPase-like protein MglA, a controller of bacterial social-motility in Myxobacteria, has evolved to control bacterial predation by Bdellovibrio.

Genome analysis of a simultaneously predatory and prey-independent, novel Bdellovibrio bacteriovorus from the River Tiber, supports in silico predictions of both ancient and recent lateral gene transfer from diverse bacteria (2012)
Journal Article
Hobley, L., Lerner, T. R., Williams, L. E., Lambert, C., Till, R., Milner, D. S., …Sockett, R. E. (2012). Genome analysis of a simultaneously predatory and prey-independent, novel Bdellovibrio bacteriovorus from the River Tiber, supports in silico predictions of both ancient and recent lateral gene transfer from diverse bacteria. BMC Genomics, 13(670), https://doi.org/10.1186/1471-2164-13-670

Background: Evolution equipped Bdellovibrio bacteriovorus predatory bacteria to invade other bacteria, digesting and replicating, sealed within them thus preventing nutrient-sharing with organisms in the surrounding environment. Bdellovibrio were... Read More about Genome analysis of a simultaneously predatory and prey-independent, novel Bdellovibrio bacteriovorus from the River Tiber, supports in silico predictions of both ancient and recent lateral gene transfer from diverse bacteria.

The Bdellovibrio bacteriovorus twin-arginine transport system has roles in predatory and prey-independent growth (2011)
Journal Article
Chang, C., Hobley, L., Till, R., Capeness, M., Kanna, M., Burtt, W., …Sockett, R. E. (2011). The Bdellovibrio bacteriovorus twin-arginine transport system has roles in predatory and prey-independent growth. Microbiology, 157(11), https://doi.org/10.1099/mic.0.052449-0

Bdellovibrio bacteriovorus grows in one of two ways: either (i) predatorily [in a host-dependent (HD) manner], when it invades the periplasm of another Gram-negative bacterium, exporting into the prey co-ordinated waves of soluble enzymes using the p... Read More about The Bdellovibrio bacteriovorus twin-arginine transport system has roles in predatory and prey-independent growth.

An inside job: Bdellovibrio bacteriovorus (2008)
Journal Article
Sockett, L., Hobley, L., Fenton, A., Woods, R., Lambert, C., Chang, C. Y., …King, S. (2008). An inside job: Bdellovibrio bacteriovorus. Microbiology Today, 35(4), 184-187