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The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress (2019)
Journal Article
Al-Ghafari, A., Elmorsy, E., Fikry, E., Alrowaili, M., & Carter, W. G. (2019). The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress. PLoS ONE, 14(11), https://doi.org/10.1371/journal.pone.0225341

The heavy metals (HMs) lead and cadmium are persistent environmental pollutants capable of inducing ill-health in exposed individuals. One of the primary sites of accumulation and potential damage from HMs is bone, and we therefore examined the acute... Read More about The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress.

Randomised, double-blind, multi-centre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B Feasibility) (2019)
Journal Article
Higginson, I., Wilcock, A., Johnson, M., Bajwah, S., Lovell, N., Yi, D., …Brown, S. (in press). Randomised, double-blind, multi-centre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B Feasibility). Thorax,

Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging (2019)
Journal Article
Chou, I., Tanasescu, R., Mougin, O. E., Gowland, P. A., Tench, C. R., Whitehouse, W. P., …Constantinescu, C. S. (2019). Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-50928-0

Whether the integrity of normal-appearing white matter (NAWM) is preserved in neuromyelitis optica spectrum disorders (NMOSD) is open to debate. To examine whether the tissue integrity of NAWM in NMOSD is compromised compared to that in healthy contr... Read More about Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging.

Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis (2019)
Journal Article
Li, Y., Reeves, R. M., Wang, X., Bassat, Q., Brooks, W. A., Cohen, C., …Zar, H. J. (2019). Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis. Lancet Global Health, 7(8), e1031-e1045. https://doi.org/10.1016/s2214-109x%2819%2930264-5

Background: Influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus are the most common viruses associated with acute lower respiratory infections in young children (

Collagen (XI) alpha-1 chain (COL11A1) is an independent prognostic factor in breast ductal carcinoma in situ (2019)
Journal Article
Toss, M. S., Miligy, I. M., Gorringe, K. L., Aleskandarany, M. A., Alkawaz, A., Mittal, K., …Rakha, E. A. (2019). Collagen (XI) alpha-1 chain (COL11A1) is an independent prognostic factor in breast ductal carcinoma in situ. Modern Pathology,

Collagen11A1 (COL11A1) is a fibrillary type collagen constituting a minor component of the extracellular matrix and plays role in tissue tensile strength. Overexpression of COL11A1 expression is associated with aggressive behavior and poor outcome in... Read More about Collagen (XI) alpha-1 chain (COL11A1) is an independent prognostic factor in breast ductal carcinoma in situ.

Switching from linear to macrocyclic gadolinium‐based contrast agents halts the relative T 1 ‐Weighted signal increase in deep gray matter of children with brain tumors: A retrospective study (2019)
Journal Article
Rowe, S. K., Rodriguez, D., Cohen, E., Grundy, R., Morgan, P. S., Jaspan, T., & Dineen, R. A. (2019). Switching from linear to macrocyclic gadolinium‐based contrast agents halts the relative T 1 ‐Weighted signal increase in deep gray matter of children with brain tumors: A retrospective study. Journal of Magnetic Resonance Imaging, doi:10.1002/jmri.26831

Background Studies have shown signal intensity (SI) changes in the brains of children exposed to repeated doses of a gadolinium‐based contrast agent (GBCA). Hypothesis The trajectory of changes in relative dentate nucleus (DN) and globus pal... Read More about Switching from linear to macrocyclic gadolinium‐based contrast agents halts the relative T 1 ‐Weighted signal increase in deep gray matter of children with brain tumors: A retrospective study.

Young adults' attitudes to sharing whole-genome sequencing information: a university-based survey (2019)
Journal Article
Stringer, P., Sharples, S., Thomson, B. J., & Garibaldi, J. M. (2019). Young adults' attitudes to sharing whole-genome sequencing information: a university-based survey. BMC Medical Genomics, 12, doi:10.1186/s12920-019-0499-2

Background Genomic services are increasingly accessible to young adults starting their independent lives with responsibility for their self-care, yet their attitudes to sharing genomic information remain under-researched. This study explored attitud... Read More about Young adults' attitudes to sharing whole-genome sequencing information: a university-based survey.

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation (2019)
Journal Article
Vara-Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K. M., Atrih, A., Foretz, M., …Hardie, D. G. (2019). Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation. Cell Reports, 27(3), 690-698.e4. https://doi.org/10.1016/j.celrep.2019.03.067

AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk. However... Read More about Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.

Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review (2019)
Journal Article
Sousa, L., Chadborn, N. H., Goodman, C., Zubair, M., Sousa, L., Gladman, J. R. F., …Gordon, A. L. (2019). Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review. BMJ Open, 9(4), 1-9. doi:10.1136/bmjopen-2018-026921

Objectives Comprehensive Geriatric Assessment (CGA) may be a way to deliver optimal care for care home residents. We used realist review to develop a theory-driven account of how CGA works in care homes. Design Realist review Setting Care ho... Read More about Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review.

Day of the week to tweet: a randomised controlled trial (2019)
Journal Article
Jayaram, M., Adams, C. E., Friedel, J. S., Mcclenaghan, E., Montgomery, A. A., Välimäki, M., …Zhao, S. (2019). Day of the week to tweet: a randomised controlled trial. BMJ Open, 9(4), doi:10.1136/bmjopen-2018-025380

Objective: To assess the effects of using health social media on different days of the working week on web activity. Design: Individually randomised controlled parallel group superiority trial. Setting: Twitter and Weibo. Participants: 194 Cochran... Read More about Day of the week to tweet: a randomised controlled trial.

Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents (2019)
Journal Article
Alvaradejo, G. G., Nguyen, H. V., Harvey, P., Gallagher, N. M., Le, D., Ottaviani, M. F., …Johnson, J. A. (2019). Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents. ACS Macro Letters, 8(4), 473-478. https://doi.org/10.1021/acsmacrolett.9b00016

The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) approach is described. First, well-defined norbornene-terminated poly(2-ethyl-2... Read More about Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents.

Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss (2019)
Journal Article
Heffernan, E., Habib, A., & Ferguson, M. (2019). Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss. International Journal of Audiology, 58(1), 45-52. doi:10.1080/14992027.2018.1533257

This study aimed to evaluate the psychometric properties of a brief, hearing-specific outcome measure: the Social Isolation Measure (SIM). In Phase 1, adults with hearing loss were invited to complete an online survey that contained the SIM, a hearin... Read More about Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss.

Impaired forward model updating in young adults with Tourette syndrome (2018)
Journal Article
Kim, S., Jackson, G. M., Dyke, K., & Jackson, S. R. (2019). Impaired forward model updating in young adults with Tourette syndrome. Brain, 142(1), 209-219. doi:10.1093/brain/awy306

Current theories of motor control emphasise how the brain may use internal models of the body to ensure accurate planning and control of movements. One such internal model - a forward model - is thought to generate an estimate of the next motor state... Read More about Impaired forward model updating in young adults with Tourette syndrome.

Development of human electrophysiological brain networks (2018)
Journal Article
Briley, P. M., Liddle, E. B., Groom, M. J., Smith, H. J. F., Morris, P. G., Colclough, G. L., …Liddle, P. F. (2018). Development of human electrophysiological brain networks. Journal of Neurophysiology, 120(6), 3122-3130. doi:10.1152/jn.00293.2018

Functional activity in the human brain is intrinsically organized into independently active, connected brain regions. These networks include sensorimotor systems, as well as higher-order cognitive networks such as the default mode network (DMN), whic... Read More about Development of human electrophysiological brain networks.

Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients (2018)
Journal Article
Bradley, C., Scott, R., Cox, E., Palaniyappan, N., Thompson, B., Ryder, D., …Francis, S. (2019). Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients. European Radiology, 29(6), 3100–3107. doi:10.1007/s00330-018-5788-1

Methods: We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before DAA therapy and after treatment completion (within 12 weeks of last DAA tablet swallowed). Results: We observed changes in... Read More about Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients.

Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial (2018)
Journal Article
Hull, M. A., Sprange, K., Hepburn, T., Tan, W., Shafayat, A., Rees, C. J., …seAFOod Collaborative Group, . (2018). Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial. Lancet, doi:10.1016/s0140-6736(18)31775-6

Background: The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) and aspirin both have proof of concept for colorectal cancer chemoprevention, aligned with an excellent safety profile. Therefore, we aimed to test the efficacy of EPA and... Read More about Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial.

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
GBD 2017 SDG Collaborators, , Bisanzio, D., & Shokraneh, F. (2018). Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 2091-2138. doi:10.1016/S0140-6736(18)32281-5

Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of " leavin... Read More about Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017.

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators, , Bisanzio, D., & Shokraneh, F. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1789-1858. doi:10.1016/S0140-6736(18)32279-7

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990... Read More about Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017.