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Osteocalcin does not influence acute or chronic inflammation in human vascular cells (2019)
Journal Article
Millar, S. A., Zala, I., Anderson, S. I., & O'Sullivan, S. E. (2019). Osteocalcin does not influence acute or chronic inflammation in human vascular cells. Journal of Cellular Physiology, https://doi.org/10.1002/jcp.29231

Some human observational studies have suggested an anti-inflammatory role of osteocalcin (OCN). An inflammatory protocol using IFN-γ and TNF-α (10 ng/mL) was employed to examine the acute (24 hr) and chronic (144 hr) effects of uncarboxylated OCN (uc... Read More about Osteocalcin does not influence acute or chronic inflammation in human vascular cells.

Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae (2019)
Journal Article
Overbey, E. G., Paul, A. M., da Silveira, W. A., Tahimic, C. G., Reinsch, S. S., Szewczyk, N., …Mao, X. W. (2019). Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae. International Journal of Molecular Sciences, 20(17), doi:10.3390/ijms20174094

Spaceflight poses many challenges for humans. Ground-based analogs typically focus on single parameters of spaceflight and their associated acute effects. This study assesses the long-term transcriptional effects following single and combination spac... Read More about Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae.

The treatment of hypertension in people with dementia: a multi-centre prospective observational cohort study (2019)
Journal Article
Welsh, T., Gladman, J., & Gordon, A. (2019). The treatment of hypertension in people with dementia: a multi-centre prospective observational cohort study. Journal of the American Medical Directors Association, 20(9), 1111-1115. doi:10.1016/j.jamda.2019.03.036

Objectives To describe the treatment of hypertension in people with dementia and collate evidence on adverse health events whilst on treatment. Design A multicenter prospective observational cohort study. Setting and participants People with... Read More about The treatment of hypertension in people with dementia: a multi-centre prospective observational cohort study.

Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly (2018)
Journal Article
Al-Dabbagh, S., McPhee, J. S., Piasecki, M., Stewart, C. E., & Al-Shanti, N. (2019). Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly. Journals of Gerontology, Series A, 74(9), 1375–1385. https://doi.org/10.1093/gerona/gly238

The key objective of this work was to investigate the impact of young and old human lymphocyte secretomes on C2C12 myoblasts regeneration. Conditioned media (CMs) were harvested from isolated young and older lymphocytes treated with (activated AC), o... Read More about Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly.

The effectiveness of drama-based activities to teach the cardiac cycle to undergraduate students (2018)
Conference Proceeding
Hughes, G., & Davies, . A. (2018). The effectiveness of drama-based activities to teach the cardiac cycle to undergraduate students

Active learning modes are thought to promote higher levels of student engagement, understanding and thus, improve test scores and satisfaction. Nevertheless, few studies have used drama as an active learning tool to learn complex physiological concep... Read More about The effectiveness of drama-based activities to teach the cardiac cycle to undergraduate students.

Short-term impact of bariatric surgery on best-corrected distance visual acuity and diabetic retinopathy progression (2018)
Journal Article
Richardson, P., Hulpus, A., & Idris, I. (2018). Short-term impact of bariatric surgery on best-corrected distance visual acuity and diabetic retinopathy progression. Obesity Surgery, doi:10.1007/s11695-018-3445-z

The immediate impact of rapid glucose lowering induced by bariatric surgery on diabetic retinopathy (DR) progression remains unclear. We present 3-year changes in the best-corrected visual acuity and DR grade in a retrospective observational study of... Read More about Short-term impact of bariatric surgery on best-corrected distance visual acuity and diabetic retinopathy progression.

The relationship between urinary albumin excretion, cardiovascular outcomes and total mortality among a large cohort of insulin-treated patients with type 2 diabetes in routine primary care practices (2018)
Journal Article
Anyanwagu, U., Donnelly, R., & Idris, I. (2018). The relationship between urinary albumin excretion, cardiovascular outcomes and total mortality among a large cohort of insulin-treated patients with type 2 diabetes in routine primary care practices. Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfy258. ISSN 0931-0509

Background: Albuminuria is a recognized diagnostic and prognostic marker of chronic kidney disease and cardiovascular (CV) risk but the well-known relationship between increments in urinary albumin:creatinine ratio (UACR) and CV outcomes and mortalit... Read More about The relationship between urinary albumin excretion, cardiovascular outcomes and total mortality among a large cohort of insulin-treated patients with type 2 diabetes in routine primary care practices.

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes (2018)
Journal Article
Doris, J. M., Millar, S. A., Idris, I., & O'Sullivan, S. E. (2018). Genetic polymorphisms of the endocannabinoid system in obesity and diabetes. Diabetes, Obesity and Metabolism, doi:10.1111/dom.13504

The endocannabinoid system (ECS) is involved in many physiological processes including fertility, pain and energy regulation. The aim of this systematic review was to examine the contribution of single nucleotide polymorphisms (SNPs) of the ECS to ad... Read More about Genetic polymorphisms of the endocannabinoid system in obesity and diabetes.

Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules (2018)
Journal Article
Clark, M. E., Bedford, L. E., Young, B., Robertson, J. F., das Nair, R., Vedhara, K., …Kendrick, D. (2018). Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules. Lung Cancer, 124, (160-167). doi:10.1016/j.lungcan.2018.08.001. ISSN 0169-5002

Objectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population. Materials and methods: This... Read More about Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules.

Feed thickeners in gastro-oesophageal reflux in infants (2018)
Journal Article
Kwok, T. C., Ojha, S., & Dorling, J. (2018). Feed thickeners in gastro-oesophageal reflux in infants. BMJ Paediatrics Open, 2(1), e000262. doi:10.1136/bmjpo-2018-000262

Gastro-oesophageal reflux (GOR) is the involuntary retrograde passage of gastric contents into the oesophagus with or without regurgitation. This is a common physiological, self-limiting condition in healthy infants with a prevalence peaking at 3–4 m... Read More about Feed thickeners in gastro-oesophageal reflux in infants.

The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia (2018)
Journal Article
McPhee, J. S., Cameron, J., Maden-Wilkinson, T., Piasecki, M., Yap, M. H., Jones, D. A., & Degens, H. (2018). The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia. Journals of Gerontology, Series A, 73(10), (1287-1294). doi:10.1093/gerona/gly040. ISSN 1079-5006

The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia remain unclear. To investigate, 40 older (20 women; age 72 ± 4 years) and 31 younger adults (15 women, age 22 ± 3 years) comple... Read More about The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia.

The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners (2018)
Journal Article
Piasecki, J., Ireland, A., Piasecki, M., Cameron, J., McPhee, J. S., & Degens, H. (2018). The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners. Scandinavian Journal of Medicine and Science in Sports, 28(5), 1559-1568. doi:10.1111/sms.13062

Regular intense endurance exercise can lead to amenorrhea with possible adverse consequences for bone health. We compared whole body and regional bone strength and skeletal muscle characteristics between amenorrheic (AA: n = 14) and eumenorrheic (EA:... Read More about The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners.

The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles (2018)
Journal Article
Piasecki, M., Ireland, A., Piasecki, J., Stashuk, D., McPhee, J., & Jones, D. (2018). The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles. European Journal of Applied Physiology, 118(4), 767-775. doi:10.1007/s00421-018-3811-5

Purpose Current methods for estimating muscle motor unit (MU) number provide values which are remarkably similar for muscles of widely differing size, probably because surface electrodes sample from similar and relatively small volumes in each mus... Read More about The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles.

Age-dependent motor unit remodelling in human limb muscles (2015)
Journal Article
Piasecki, M., Ireland, A., Jones, D. A., & McPhee, J. S. (2016). Age-dependent motor unit remodelling in human limb muscles. Biogerontology, 17(3), (485-496). doi:10.1007/s10522-015-9627-3. ISSN 1389-5729

Voluntary control of skeletal muscle enables humans to interact with and manipulate the environment. Lower muscle mass, weakness and poor coordination are common complaints in older age and reduce physical capabilities. Attention has focused on ways... Read More about Age-dependent motor unit remodelling in human limb muscles.

Female adipocyte androgen synthesis and the effects of insulin (2014)
Journal Article
Cadagan, D., Khan, R., & Amer, S. (2014). Female adipocyte androgen synthesis and the effects of insulin. Molecular Genetics and Metabolism Reports, 1, 254-263. doi:10.1016/j.ymgmr.2014.05.002

The metabolic syndrome is a cluster of metabolic disorders characterized by insulin resistance and hyperinsulinaemia, and its presence can increase the risk of cardiovascular disease significantly. The metabolic syndrome is associated with increased... Read More about Female adipocyte androgen synthesis and the effects of insulin.