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A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects (2018)
Journal Article
Sloan, T. J., Jalanka, J., Major, G. A. D., Krishnasamy, S., Pritchard, S., Abdelrazig, S., …Spiller, R. C. (2018). A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects. PLoS ONE, 13(7), doi:10.1371/journal.pone.0201410. ISSN 1932-6203

Background & aims Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviatio... Read More about A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.

A comprehensive assessment of benign genetic variability for neurodegenerative disorders (2018)
Journal Article
Guerreiro, R., Sassi, C., Gibbs, J., Edsall, C., Hernandez, D., Brown, K., …Bras, J. (2018). A comprehensive assessment of benign genetic variability for neurodegenerative disorders. doi:10.1101/270686

Over the last few years, as more and more sequencing studies have been performed, it has become apparent that the identification of pathogenic mutations is, more often than not, a complex issue. Here, with a focus on neurodegenerative diseases, we ha... Read More about A comprehensive assessment of benign genetic variability for neurodegenerative disorders.

High mobility group protein B1 is a predictor of poor survival in ovarian cancer (2017)
Journal Article
Machado, L. R., Moseley, P. M., Moss, R., Deen, S., Nolan, C. C., Spendlove, I., …Durrant, L. (2017). High mobility group protein B1 is a predictor of poor survival in ovarian cancer. Oncotarget, doi:10.18632/oncotarget.20538

High-mobility group protein B1 (HMGB1) has been implicated in numerous tumour types where expression regulates tumour cell growth and survival. We hypothesised that high HMGB1 expression in ovarian tumours would predict poor patient survival. Using... Read More about High mobility group protein B1 is a predictor of poor survival in ovarian cancer.

MMP-1 activation contributes to airway smooth muscle growth and asthma severity (2016)
Journal Article
Soomro, I., Naveed, S., Clements, D., Jackson, D. J., Philp, C., Billington, C. K., …Johnson, S. R. (2017). MMP-1 activation contributes to airway smooth muscle growth and asthma severity. American Journal of Respiratory and Critical Care Medicine, 195(8), 1000-1009. https://doi.org/10.1164/rccm.201604-0822OC

Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity. Methods: Patients with stable ast... Read More about MMP-1 activation contributes to airway smooth muscle growth and asthma severity.

Cystic Fibrosis isolates of Pseudomonas aeruginosa retain iron-regulated antimicrobial activity against Staphylococcus aureus through the action of multiple alkylquinolones (2016)
Journal Article
Nguyen, A. T., Jones, J. W., Cámara, M., Williams, P., Kane, M. A., & Oglesby-Sherrouse, A. G. (2016). Cystic Fibrosis isolates of Pseudomonas aeruginosa retain iron-regulated antimicrobial activity against Staphylococcus aureus through the action of multiple alkylquinolones. Frontiers in Microbiology, 7, doi:10.3389/fmicb.2016.01171

Cystic fibrosis (CF) is a hereditary disease that predisposes individuals to pulmonary dysfunction and chronic infections. Early infection of the CF lung with Staphylococcus aureus is common, while Pseudomonas aeruginosa becomes dominant as disease p... Read More about Cystic Fibrosis isolates of Pseudomonas aeruginosa retain iron-regulated antimicrobial activity against Staphylococcus aureus through the action of multiple alkylquinolones.

Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment (2015)
Journal Article
Alexander, M., Magennis, E., Hook, A., Davies, M., Alexander, C., Williams, P., & Alexander, M. R. (2016). Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment. Acta Biomaterialia, 34, 84-92. https://doi.org/10.1016/j.actbio.2015.11.008

Controlling the colonisation of materials by microorganisms is important in a wide range of industries and clinical settings. To date, the underlying mechanisms that govern the interactions of bacteria with material surfaces remain poorly understood,... Read More about Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment.

Cationic polymer mediated bacterial clustering: cell-adhesive properties of homo- and copolymers (2015)
Journal Article
Louzao, I., Sui, C., Winzer, K., Fernandez-Trillo, F., & Alexander, C. (2015). Cationic polymer mediated bacterial clustering: cell-adhesive properties of homo- and copolymers. European Journal of Pharmaceutics and Biopharmaceutics, 95, 47-62. doi:10.1016/j.ejpb.2015.05.026

New anti-infective materials are needed urgently as alternatives to conventional biocides. It has recently been established that polymer materials designed to bind to the surface of bacteria can induce the formation of cell clusters which enhance the... Read More about Cationic polymer mediated bacterial clustering: cell-adhesive properties of homo- and copolymers.

Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies (2014)
Journal Article
Edwards, V. C., McClure, P., Brown, R. J., Thompson, E., Irving, W. L., & Ball, J. K. (in press). Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies. Journal of General Virology, 95(1), doi:10.1099/vir.0.057828-0

Sequence analysis is used to define the molecular epidemiology and evolution of the hepatitis C virus. Whilst most studies have shown that individual patients harbour viruses that are derived from a limited number of highly related strains, some rece... Read More about Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies.

Insights of biosurfactant producing Serratia marcescens strain W2.3 isolated from diseased tilapia fish: a draft genome analysis (2013)
Journal Article
Chan, X. Y., Chang, C. Y., Hong, K. W., Tee, K. K., Yin, W. F., & Chan, K. G. (2013). Insights of biosurfactant producing Serratia marcescens strain W2.3 isolated from diseased tilapia fish: a draft genome analysis. Gut Pathogens, 5(Octobe), doi:10.1186/1757-4749-5-29

Background Serratia marcescens is an opportunistic bacterial pathogen with broad range of host ranging from vertebrates, invertebrates and plants. S. marcescens strain W2.3 was isolated from a diseased tilapia fish and it was suspected to be the cau... Read More about Insights of biosurfactant producing Serratia marcescens strain W2.3 isolated from diseased tilapia fish: a draft genome analysis.

Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement (2013)
Journal Article
Vankemmelbeke, M., Housden, N. G., James, R., Kleanthous, C., & Penfold, C. N. (2013). Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement. Microbiology Open, 2(5), doi:10.1002/mbo3.122

Nuclease colicins bind their target receptor BtuB in the outer membrane of sensitive Escherichia coli cells in the form of a high-affinity complex with their cognate immunity proteins. The release of the immunity protein from the colicin complex is a... Read More about Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement.

Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR) (2013)
Journal Article
Ilangovan, A., Fletcher, M., Rampioni, G., Pustelny, C., Rumbaugh, K., Heeb, S., …Williams, P. (2013). Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR). PLoS Pathogens, 9(7), doi:10.1371/journal.ppat.1003508

Bacterial populations co-ordinate gene expression collectively through quorum sensing (QS), a cell-to-cell communication mechanism employing diffusible signal molecules. The LysR-type transcriptional regulator (LTTR) protein PqsR (MvfR) is a key comp... Read More about Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR).

Prevalence and phase variable expression status of two autotransporters, NalP and MspA, in carriage and disease isolates of Neisseria meningitidis (2013)
Journal Article
Oldfield, N. J., Matar, S., Bidmos, F. A., Alamro, M., Neal, K. R., Turner, D. P., …Ala'Aldeen, D. A. (2013). Prevalence and phase variable expression status of two autotransporters, NalP and MspA, in carriage and disease isolates of Neisseria meningitidis. PLoS ONE, 8(7), doi:10.1371/journal.pone.0069746

Neisseria meningitidis is a human nasopharyngeal commensal capable of causing life-threatening septicemia and meningitis. Many meningococcal surface structures, including the autotransporter proteins NalP and MspA, are subject to phase variation (PV)... Read More about Prevalence and phase variable expression status of two autotransporters, NalP and MspA, in carriage and disease isolates of Neisseria meningitidis.

Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer? (2013)
Journal Article
Abdel-Fatah, T., Arora, A., Gorguc, I., Abbotts, R., Beebeejaun, S., Storr, S. J., …Madhusudan, S. (2013). Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?. Antioxidants and Redox Signaling, 18(18), doi:10.1089/ars.2012.4873

Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA rep... Read More about Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?.

Lung cancer diagnosed following emergency admission: a mixed methods study protocol to improve understanding of patients’ characteristics, needs, experiences and outcomes (2013)
Journal Article
Wilcock, A., Crosby, V., Freer, S., Freemantle, A., Caswell, G., & Seymour, J. (2013). Lung cancer diagnosed following emergency admission: a mixed methods study protocol to improve understanding of patients’ characteristics, needs, experiences and outcomes. BMC Palliative Care, 12(May), doi:10.1186/1472-684X-12-24

Background Lung cancer is the leading cause of death from cancer in England. About 40% of patients with lung cancer are diagnosed following an emergency admission (DFEA) to hospital. DFEA is more common in women, and more likely with increasing age... Read More about Lung cancer diagnosed following emergency admission: a mixed methods study protocol to improve understanding of patients’ characteristics, needs, experiences and outcomes.

Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays (2013)
Journal Article
Hook, A. L., Chang, C., Yang, J., Atkinson, S., Langer, R., Anderson, D. G., …Alexander, M. R. (2013). Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials, 25(18), doi:10.1002/adma.201204936

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacteria... Read More about Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays.

Molecular networks of human muscle adaptation to exercise and age (2013)
Journal Article
Phillips, B. E., Williams, J. P., Gustafsson, T., Bouchard, C., Rankinen, T., Knudsen, S., …Atherton, P. J. (2013). Molecular networks of human muscle adaptation to exercise and age. PLoS Genetics, 9(3), doi:10.1371/journal.pgen.1003389

Physical activity and molecular ageing presumably interact to precipitate musculoskeletal decline in humans with age. Herein, we have delineated molecular networks for these two major components of sarcopenic risk using multiple independent clinical... Read More about Molecular networks of human muscle adaptation to exercise and age.

Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD) (2013)
Journal Article
Wang, J., Urbanowicz, R. A., Tighe, P. J., Todd, I., Corne, J. M., & Fairclough, L. C. (2013). Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD). PLoS ONE, 8(3), doi:10.1371/journal.pone.0058556

Background:CD8+ T-lymphocytes, natural killer T-like cells (NKT-like cells, CD56+CD3+) and natural killer cells (NK cells, CD56+CD3−) are the three main classes of human killer cells and they are implicated in the pathogenesis of chronic obstructive... Read More about Differential activation of killer cells in the circulation and the lung: a study of current smoking status and chronic obstructive pulmonary disease (COPD).

Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells (2013)
Journal Article
Sultana, R., Abdel-Fatah, T., Perry, C., Moseley, P., Albarakti, N., Mohan, V., …Madhusudan, S. (2013). Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells. PLoS ONE, 8(2), doi:10.1371/journal.pone.0057098

Introduction Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in sin... Read More about Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells.

Bacterial cooperation in the wild and in the clinic: are pathogen social behaviours relevant outside the laboratory? (2013)
Journal Article
Harrison, F. (2013). Bacterial cooperation in the wild and in the clinic: are pathogen social behaviours relevant outside the laboratory?. BioEssays, 35(2), doi:10.1002/bies.201200154

Individual bacterial cells can communicate via quorum sensing, cooperate to harvest nutrients from their environment, form multicellular biofilms, compete over resources and even kill one another. When the environment that bacteria inhabit is an anim... Read More about Bacterial cooperation in the wild and in the clinic: are pathogen social behaviours relevant outside the laboratory?.