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Cochrane systematic review and meta-analysis of botulinum toxin for the prevention of migraine (2019)
Journal Article
Herd, C. P., Tomlinson, C. L., Rick, C., Scotton, W. J., Edwards, J., Ives, N. J., …Sinclair, A. (2019). Cochrane systematic review and meta-analysis of botulinum toxin for the prevention of migraine. BMJ Open, 9(7), doi:10.1136/bmjopen-2018-027953

Objectives To assess the effects of botulinum toxin for prevention of migraine in adults. Design Systematic review and meta-analysis. Data sources CENTRAL, MEDLINE, Embase and trial registries. Eligibility criteria We included randomised contr... Read More about Cochrane systematic review and meta-analysis of botulinum toxin for the prevention of migraine.

Rating the intelligibility of dysarthic speech amongst people with Parkinson’s Disease: a comparison of trained and untrained listeners (2019)
Journal Article
Smith, C. H., Patel, S., Woolley, R. L., Brady, M. C., Rick, C. E., Halfpenny, R., …Sackley, C. M. (2019). Rating the intelligibility of dysarthic speech amongst people with Parkinson’s Disease: a comparison of trained and untrained listeners. Clinical Linguistics & Phonetics, 1-8. doi:10.1080/02699206.2019.1604806

Intelligibility of speech is a key outcome in speech and language therapy (SLT) and research. SLT students frequently participate as raters of intelligibility but we lack information about whether they rate intelligibility in the same way as the gene... Read More about Rating the intelligibility of dysarthic speech amongst people with Parkinson’s Disease: a comparison of trained and untrained listeners.

Botulinum toxins for the prevention of migraine in adults (2018)
Journal Article
Herd, C. P., Tomlinson, C. L., Rick, C., Scotton, W. J., Edwards, J., Ives, N., …Sinclair, A. (2018). Botulinum toxins for the prevention of migraine in adults. Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD011616.pub2

Background Migraine occurs in around 15% of adults and is ranked as the seventh most disabling disease amongst all diseases globally. Despite the available treatments many people suffer prolonged and frequent attacks which have a major impact on the... Read More about Botulinum toxins for the prevention of migraine in adults.

Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson’s disease: a pilot randomised controlled trial (PD COMM pilot) (2018)
Journal Article
Sackley, C. M., Smith, C. H., Rick, C. E., Brady, M. C., Ives, N., Patel, S., …Clarke, C. E. (2018). Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson’s disease: a pilot randomised controlled trial (PD COMM pilot). Pilot and Feasibility Studies, 4, 1-10. doi:10.1186/s40814-017-0222-z

Background: Speech-related problems are common in Parkinson’s disease (PD), but there is little evidence for the effectiveness of standard speech and language therapy (SLT) or Lee Silverman Voice Treatment (LSVT LOUD®). Methods: The PD COMM pilot wa... Read More about Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson’s disease: a pilot randomised controlled trial (PD COMM pilot).

Randomised controlled trial of bariatric surgery versus a community weight loss programme for the sustained treatment of idiopathic intracranial hypertension: the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) protocol (2017)
Journal Article
Ottridge, R., Mollan, S. P., Botfield, H., Frew, E., Ives, N. J., Matthews, T., …Sinclair, A. J. (2017). Randomised controlled trial of bariatric surgery versus a community weight loss programme for the sustained treatment of idiopathic intracranial hypertension: the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) protocol. BMJ Open, 7(9), 1-8. doi:10.1136/bmjopen-2017-017426

Introduction: Effective treatments are lacking for idiopathic intracranial hypertension (IIH), a condition characterised by raised intracranial pressure (ICP) and papilloedema, and found primarily in obese women. Weight loss and lowering body mass in... Read More about Randomised controlled trial of bariatric surgery versus a community weight loss programme for the sustained treatment of idiopathic intracranial hypertension: the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) protocol.

Assessing the Efficacy and Safety of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in the Idiopathic Intracranial Hypertension Drug Trial, IIH:DT: Clinical Methods and Design for a Phase II Randomized Controlled Trial (2017)
Journal Article
Markey, K. A., Ottridge, R., Mitchell, J. L., Rick, C., Woolley, R., Ives, N., …Sinclair, A. J. (2017). Assessing the Efficacy and Safety of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in the Idiopathic Intracranial Hypertension Drug Trial, IIH:DT: Clinical Methods and Design for a Phase II Randomized Controlled Trial. JMIR Research Protocols, 6(9), 1-10. doi:10.2196/resprot.7806

Background: Idiopathic intracranial hypertension (IIH) is a condition with few effective management options. So far, there have been no randomized controlled trials evaluating new treatments in IIH. Objectives: The purpose of this paper is to outl... Read More about Assessing the Efficacy and Safety of an 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in the Idiopathic Intracranial Hypertension Drug Trial, IIH:DT: Clinical Methods and Design for a Phase II Randomized Controlled Trial.

The PD COMM trial: a protocol for the process evaluation of a randomised trial assessing the effectiveness of two types of SLT for people with Parkinson’s disease (2017)
Journal Article
Masterson-Algar, P., Burton, C. R., Brady, M. C., Nicoll, A., Clarke, C. E., Rick, C., …Sackley, C. M. (2017). The PD COMM trial: a protocol for the process evaluation of a randomised trial assessing the effectiveness of two types of SLT for people with Parkinson’s disease. Trials, 18(1), 78. doi:10.1186/s13063-017-2130-1

Background The PD COMM trial is a phase III multi-centre randomised controlled trial whose aim is to evaluate the effectiveness and cost-effectiveness of two approaches to speech and language therapy (SLT) compared with no SLT intervention (control)... Read More about The PD COMM trial: a protocol for the process evaluation of a randomised trial assessing the effectiveness of two types of SLT for people with Parkinson’s disease.

Coding accuracy for Parkinson's disease hospital admissions: implications for healthcare planning in the UK (2017)
Journal Article
Muzerengi, S., Rick, C., Begaj, I., Ives, N., Evison, F., Woolley, R., & Clarke, C. (2017). Coding accuracy for Parkinson's disease hospital admissions: implications for healthcare planning in the UK. Public Health, 146, 4-9. doi:10.1016/j.puhe.2016.12.024

Objectives Hospital Episode Statistics data are used for healthcare planning and hospital reimbursements. Reliability of these data is dependent on the accuracy of individual hospitals reporting Secondary Uses Service (SUS) which includes hospitalis... Read More about Coding accuracy for Parkinson's disease hospital admissions: implications for healthcare planning in the UK.

Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer (2016)
Journal Article
Sundar, S., Rick, C., Dowling, F., Au, P., Snell, K., Rai, N., …Deeks, J. (2016). Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer. BMJ Open, 6(8), doi:10.1136/bmjopen-2015-010333

Patients’ experiences of deep brain stimulation for Parkinson's disease: a qualitative systematic review and synthesis (2016)
Journal Article
Mathers, J., Rick, C., Jenkinson, C., Garside, R., Pall, H., Mitchell, R., …Jones, L. L. (2016). Patients’ experiences of deep brain stimulation for Parkinson's disease: a qualitative systematic review and synthesis. BMJ Open, 6(6), 1-10. doi:10.1136/bmjopen-2016-011525

Objective: To review and synthesise qualitative research studies that have explored patients’ experience of deep brain stimulation (DBS) in advanced Parkinson's disease (PD). Design: Systematic review and meta-synthesis of 7 original papers, using... Read More about Patients’ experiences of deep brain stimulation for Parkinson's disease: a qualitative systematic review and synthesis.

Cost‐utility analysis of deep brain stimulation surgery plus best medical therapy versus best medical therapy in patients with Parkinson's: Economic evaluation alongside the PD SURG trial (2016)
Journal Article
McIntosh, E., Gray, A., Daniels, J., Gill, S., Ives, N., Jenkinson, C., …on behalf of The PD SURG Collaborators Group, . (2016). Cost‐utility analysis of deep brain stimulation surgery plus best medical therapy versus best medical therapy in patients with Parkinson's: Economic evaluation alongside the PD SURG trial. Movement Disorders, 31(8), 1173-1182. doi:10.1002/mds.26423

Introduction Williams and colleagues reported that DBS surgery for patients with advanced PD improves motor function and quality of life compared to best medical therapy alone at 1 year, but with surgery‐related side effects in a minority. This ar... Read More about Cost‐utility analysis of deep brain stimulation surgery plus best medical therapy versus best medical therapy in patients with Parkinson's: Economic evaluation alongside the PD SURG trial.

Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial (2016)
Journal Article
Clarke, C. E., Patel, S., Ives, N., Rick, C. E., Dowling, F., Woolley, R., …Sackley, C. M. (in press). Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial. JAMA Neurology, 73(3), doi:10.1001/jamaneurol.2015.4452

IMPORTANCE It is unclear whether physiotherapy and occupational therapy are clinically effective and cost-effective in Parkinson disease (PD). OBJECTIVE To perform a large pragmatic randomized clinical trial to evaluate the clinical effectiveness of... Read More about Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial.

A systematic review of interventions to reduce hospitalisation in Parkinson's disease (2016)
Journal Article
Muzerengi, S., Herd, C., Rick, C., & Clarke, C. (2016). A systematic review of interventions to reduce hospitalisation in Parkinson's disease. Parkinsonism and Related Disorders, 24, 3-7. doi:10.1016/j.parkreldis.2016.01.011

The neurodegenerative process in Parkinson's disease (PD) results in a relentless progression of motor and non-motor symptoms. Affected individuals are frequently hospitalised for complications of the disease including falls, fractures, infections, a... Read More about A systematic review of interventions to reduce hospitalisation in Parkinson's disease.

A cluster randomised feasibility trial evaluating six-month nutritional interventions in the treatment of malnutrition in care home-dwelling adults: recruitment, data collection and protocol (2015)
Journal Article
Stow, R., Rushton, A., Ives, N., Smith, C., & Rick, C. (2015). A cluster randomised feasibility trial evaluating six-month nutritional interventions in the treatment of malnutrition in care home-dwelling adults: recruitment, data collection and protocol. Pilot and Feasibility Studies, 1(3), doi:10.1186/2055-5784-1-3

Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial (2014)
Journal Article
Daniels, J., Gray, R., Ives, N., Rick, C., Patel, S., Gray, A., …Clarke, C. (2014). Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial. Lancet, 384(9949), 1196-1205. doi:10.1016/S0140-6736(14)60683-8

Background Whether initial treatment for Parkinson's disease should consist of levodopa, dopamine agonists, or monoamine oxidase type B inhibitors (MAOBI) is uncertain. We aimed to establish which of these three classes of drug, as initial treatment... Read More about Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial.

Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot): study protocol for a randomized controlled trial (2014)
Journal Article
Sackley, C. M., Smith, C. H., Rick, C., Brady, M. C., Ives, N., Patel, R., …Clarke, C. (2014). Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot): study protocol for a randomized controlled trial. Trials, 15, doi:10.1186/1745-6215-15-213

Background: Parkinson’s disease is a common movement disorder affecting approximately 127,000 people in the UK, with an estimated two thirds having speech-related problems. Currently there is no preferred approach to speech and language therapy withi... Read More about Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot): study protocol for a randomized controlled trial.

Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial (2010)
Journal Article
Williams, A., Gill, S., Varma, T., Jenkinson, C., Quinn, N., Mitchell, R., …Wheatley, K. (2010). Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial. Lancet Neurology, 9(6), 581-591. doi:10.1016/s1474-4422(10)70093-4