Skip to main content

Research Repository

Advanced Search

All Outputs (104)

Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., …Cook, J. A. (2023). Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial. The Lancet Rheumatology, 6(2), e92-e104. https://doi.org/10.1016/s2665-9913%2823%2900298-9

Background: Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.

Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial (2023)
Journal Article
Abhishek, A., Peckham, N., Pade, C., Gibbons, J. M., Cureton, L., Francis, A., …Study investigators, V. (in press). Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial. The Lancet Rheumatology,

Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort (2023)
Journal Article
McWilliams, D. F., Yue, B., Smith, S. L., Stocks, J., Doherty, M., Valdes, A. M., …Walsh, D. A. (2023). Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort. Journal of Personalized Medicine, 13(10), Article 1450. https://doi.org/10.3390/jpm13101450

Knee pain is associated with lower muscle strength, and both contribute to disability. Peripheral and central neurological mechanisms contribute to OA pain. Understanding the relative contributions of pain mechanisms to muscle strength might help fut... Read More about Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.

A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts (2023)
Journal Article
Nogal, A., Tettamanzi, F., Dong, Q., Louca, P., Visconti, A., Christiansen, C., …Menni, C. (2023). A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts. Diabetes, 72(12), 1870–1880. https://doi.org/10.2337/db23-0170

Prediabetes is a metabolic condition associated with gut microbiome composition, though mechanisms remain elusive. We searched for faecal metabolites, a readout of gut microbiome function, associated with impaired fasting glucose (IFG) in 142 individ... Read More about A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts.

Feasibility of conducting a cohort randomized controlled trial assessing the effectiveness of a nurse-led package of care for knee pain (2023)
Journal Article
Fuller, A., Hall, M., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., …Abhishek, A. (in press). Feasibility of conducting a cohort randomized controlled trial assessing the effectiveness of a nurse-led package of care for knee pain. Rheumatology, Article kead432. https://doi.org/10.1093/rheumatology/kead432

Objective To evaluate the feasibility of conducting a cohort randomized controlled trial (RCT) of a nurse-led package of care for knee pain and determining a treatment sequence for use in a future trial. Methods This study was an open-label, thr... Read More about Feasibility of conducting a cohort randomized controlled trial assessing the effectiveness of a nurse-led package of care for knee pain.

Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review (2023)
Journal Article
O’Sullivan, O., Ladlow, P., Steiner, K., Kuyser, D., Ali, O., Stocks, J., …Kluzek, S. (2023). Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review. Osteoarthritis and Cartilage Open, 5(3), Article 100385. https://doi.org/10.1016/j.ocarto.2023.100385

Introduction Osteoarthritis (OA) results from various aetiologies, including joint morphology, biomechanics, inflammation, and injury. The latter is implicated in post-traumatic OA, which offers a paradigm to identify potential biomarkers enabling e... Read More about Knee MRI biomarkers associated with structural, functional and symptomatic changes at least a year from ACL injury - A systematic review.

Osteoarthritis in the UK Armed Forces: a review of its impact, treatment and future research (2023)
Journal Article
O'Sullivan, O., Behan, F. P., Coppack, R. J., Stocks, J., Kluzek, S., Valdes, A. M., & Bennett, A. N. (2023). Osteoarthritis in the UK Armed Forces: a review of its impact, treatment and future research. BMJ Military Health, https://doi.org/10.1136/military-2023-002390

Within the UK Armed Forces, musculoskeletal injuries account for over half of all medical downgrades and discharges. Data from other Armed Forces show that osteoarthritis (OA), more common in military personnel, is likely to contribute to this, both... Read More about Osteoarthritis in the UK Armed Forces: a review of its impact, treatment and future research.

The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery (2023)
Journal Article
Louca, P., Meijnikman, A. S., Nogal, A., Asnicar, F., Attaye, I., Vijay, A., …Menni, C. (2023). The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery. Cell Reports Medicine, 4(4), Article 100993. https://doi.org/10.1016/j.xcrm.2023.100993

Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 s... Read More about The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery.

Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study (2023)
Journal Article
Mehta, O., Vijay, A., Gohir, S. A., Kelly, T., Zhang, W., Doherty, M., …Valdes, A. M. (2023). Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study. Journal of Pain, https://doi.org/10.1016/j.jpain.2023.02.023

Osteoarthritis (OA) is the most common arthritis affecting synovial joints such as knees and hips of millions of people globally. Usage-related joint pain and reduced function are the most common symptoms experienced by people with OA. To improve pai... Read More about Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study.

How people with knee pain understand why their pain changes or remains the same over time: A qualitative study (2023)
Journal Article
Walsh, D. A., Rathbone, J., Akin-Akinyosoye, K., Fernandes, G. S., Valdes, A. M., McWilliams, D. F., …Ferguson, E. (2023). How people with knee pain understand why their pain changes or remains the same over time: A qualitative study. Osteoarthritis and Cartilage Open, 5(2), Article 100345. https://doi.org/10.1016/j.ocarto.2023.100345

Objectives Guidelines recommend knee osteoarthritis pain management based on biopsychosocial mechanisms. Treatment adherence and effectiveness may be affected if there is a mismatch between patient perspectives and treatment focus. We therefore exam... Read More about How people with knee pain understand why their pain changes or remains the same over time: A qualitative study.

Reproducible microbiome composition signatures of anxiety and depressive symptoms (2023)
Journal Article
Kouraki, A., Kelly, A., Vijay, A., Gohir, S., Astbury, S., Georgopoulos, V., …Valdes, A. M. (2023). Reproducible microbiome composition signatures of anxiety and depressive symptoms. Computational and Structural Biotechnology Journal, 21, 5326-5336. https://doi.org/10.1016/j.csbj.2023.10.035

The gut microbiome is a significant contributor to mental health, with growing evidence linking its composition to anxiety and depressive disorders. Gut microbiome composition is associated with signs of anxiety and depression both in clinically diag... Read More about Reproducible microbiome composition signatures of anxiety and depressive symptoms.

Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity (2022)
Journal Article
Iwabuchi, S. J., Drabek, M. M., Cottam, W. J., Tadjibaev, A., Mohammadi-Nejad, A. R., Sotiropoulos, S., …Auer, D. P. (2022). Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity. European Journal of Neuroscience, 57(2), 373-387. https://doi.org/10.1111/ejn.15880

The reciprocal interaction between pain and negative affect is acknowledged but pain-related alterations in brain circuits involved in this interaction, such as the mediodorsal thalamus (MDThal), still require a better understanding. We sought to inv... Read More about Medio-dorsal thalamic dysconnectivity in chronic knee pain: A possible mechanism for negative affect and pain comorbidity.

How people wake up is associated with previous night’s sleep together with physical activity and food intake (2022)
Journal Article
Vallat, R., Berry, S. E., Tsereteli, N., Capdevila, J., Khatib, H. A., Valdes, A. M., …Walker, M. P. (2022). How people wake up is associated with previous night’s sleep together with physical activity and food intake. Nature Communications, 13(1), Article 7116. https://doi.org/10.1038/s41467-022-34503-2

How people wake up and regain alertness in the hours after sleep is related to how they are sleeping, eating, and exercising. Here, in a prospective longitudinal study of 833 twins and genetically unrelated adults, we demonstrate that how effectively... Read More about How people wake up is associated with previous night’s sleep together with physical activity and food intake.

Postprandial Responses to a Standardised Meal in Hypertension: The Mediatory Role of Visceral Fat Mass (2022)
Journal Article
Louca, P., Berry, S. E., Bermingham, K., Franks, P. W., Wolf, J., Spector, T. D., …Menni, C. (2022). Postprandial Responses to a Standardised Meal in Hypertension: The Mediatory Role of Visceral Fat Mass. Nutrients, 14(21), Article 4499. https://doi.org/10.3390/nu14214499

Postprandial insulinaemia, triglyceridaemia and measures of inflammation are thought to be more closely associated with cardiovascular risk than fasting measures. Although hypertension is associated with altered fasting metabolism, it is unknown as t... Read More about Postprandial Responses to a Standardised Meal in Hypertension: The Mediatory Role of Visceral Fat Mass.

Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study (2022)
Journal Article
Bermingham, K. M., Linenberg, I., Hall, W. L., Kadé, K., Franks, P. W., Davies, R., …Berry, S. E. (2022). Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study. EBioMedicine, 85, Article 104303. https://doi.org/10.1016/j.ebiom.2022.104303

Background: The menopause transition is associated with unfavourable alterations in health. However, postprandial metabolic changes and their mediating factors are poorly understood. Methods: The PREDICT 1 UK cohort (n=1002; pre- n=366, peri- n=5... Read More about Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study.

Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD) (2022)
Journal Article
Georgopoulos, V., Smith, S., McWilliams, D. F., Steultjens, M. P. M., Williams, A., Price, A., …Walsh, D. A. (2023). Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD). Osteoarthritis and Cartilage, 31(1), 83-95. https://doi.org/10.1016/j.joca.2022.08.011

Objective: In order to facilitate data pooling between studies, we explored harmonisation of patient-reported outcome measures (PROMs) in people with knee pain due to osteoarthritis or knee trauma, using the Patient Acceptable Symptom State scores (P... Read More about Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD).

Perspective: Leveraging the Gut Microbiota to Predict Personalized Responses to Dietary, Prebiotic, and Probiotic Interventions (2022)
Journal Article
Gibbons, S. M., Gurry, T., Lampe, J. W., Chakrabarti, A., Dam, V., Everard, A., …Miani, M. (2022). Perspective: Leveraging the Gut Microbiota to Predict Personalized Responses to Dietary, Prebiotic, and Probiotic Interventions. Advances in Nutrition, 13(5), 1450-1461. https://doi.org/10.1093/advances/nmac075

Humans often show variable responses to dietary, prebiotic, and probiotic interventions. Emerging evidence indicates that the gut microbiota is a key determinant for this population heterogeneity. Here, we provide an overview of some of the major com... Read More about Perspective: Leveraging the Gut Microbiota to Predict Personalized Responses to Dietary, Prebiotic, and Probiotic Interventions.

Development of Food Group Tree-Based Analysis and Its Association with Non-Alcoholic Fatty Liver Disease (NAFLD) and Co-Morbidities in a South Indian Population: A Large Case-Control Study (2022)
Journal Article
Vijay, A., Al-Awadi, A., Chalmers, J., Balakumaran, L., Grove, J. I., Valdes, A. M., …Aithal, G. P. (2022). Development of Food Group Tree-Based Analysis and Its Association with Non-Alcoholic Fatty Liver Disease (NAFLD) and Co-Morbidities in a South Indian Population: A Large Case-Control Study. Nutrients, 14(14), Article 2808. https://doi.org/10.3390/nu14142808

Background: Non-alcoholic fatty liver disease (NAFLD) is a global problem growing in parallel to the epidemics of obesity and diabetes, with South Asians being particularly susceptible. Nutrition and behaviour are important modifiers of the disease,... Read More about Development of Food Group Tree-Based Analysis and Its Association with Non-Alcoholic Fatty Liver Disease (NAFLD) and Co-Morbidities in a South Indian Population: A Large Case-Control Study.

Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial (2022)
Journal Article
Abhishek, A., Boyton, R. J., Peckham, N., McKnight, Á., Coates, L. C., Bluett, J., …Cook, J. A. (2022). Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial. Lancet Respiratory Medicine, 10(9), 840-850. https://doi.org/10.1016/S2213-2600%2822%2900186-2

Background: Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the... Read More about Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial.

Upregulated expression of FFAR2 and SOC3 genes is associated with gout (2022)
Journal Article
Orji, O. C., López-Domínguez, M. B., Sandoval-Plata, G., Guetta-Baranes, T., Valdes, A. M., Doherty, M., …Abhishek, A. (2023). Upregulated expression of FFAR2 and SOC3 genes is associated with gout. Rheumatology, 62(2), 977-983. https://doi.org/10.1093/rheumatology/keac360

Objective To examine the expression of Free fatty acid receptor 2 (FFAR2) and Suppressor of cytokine signalling 3 (SOCS3) genes in asymptomatic hyperuricaemia (AH), AH with MSU crystal deposition, inter-critical gout and gout flare. Methods Study... Read More about Upregulated expression of FFAR2 and SOC3 genes is associated with gout.