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Mechanisms affecting the gut of preterm infants in enteral feeding trials: A nested cohort within a randomised controlled trial of lactoferrin (2022)
Journal Article
Young, G. R., Berrington, J. E., Cummings, S., Dorling, J., Ewer, A. K., Frau, A., …Embleton, N. D. (2023). Mechanisms affecting the gut of preterm infants in enteral feeding trials: A nested cohort within a randomised controlled trial of lactoferrin. Archives of Disease in Childhood. Fetal and Neonatal Edition, 108(3), 272-279. https://doi.org/10.1136/archdischild-2022-324477

Objective: To determine the impact of supplemental bovine lactoferrin on the gut microbiome and metabolome of preterm infants.

Design: Cohort study nested within a randomised controlled trial (RCT). Infants across different trial arms were matched... Read More about Mechanisms affecting the gut of preterm infants in enteral feeding trials: A nested cohort within a randomised controlled trial of lactoferrin.

Umpolung Synthesis of Pyridyl Ethers by Bi(V)‐Mediated O‑Arylation of Pyridones (2022)
Journal Article
Ruffell, K., Gallegos, L., Ling, K., Paton, R. S., & Ball, L. T. (2022). Umpolung Synthesis of Pyridyl Ethers by Bi(V)‐Mediated O‑Arylation of Pyridones. Angewandte Chemie International Edition, 61(51), Article e202212873. https://doi.org/10.1002/anie.202212873

We report that O-selective arylation of 2- and 4-pyridones with arylboronic acids is affected by a modular, bismacycle-based system. The utility of this umpolung approach to pyridyl ethers, which is complementary to conventional methods based on S N... Read More about Umpolung Synthesis of Pyridyl Ethers by Bi(V)‐Mediated O‑Arylation of Pyridones.

Environmental Performance Feedback and Timing of Reshoring: Perspectives from the Behavioural Theory of the Firm (2022)
Journal Article
Zhang, M., Shui, X., Smart, P., Wang, X., & Chen, J. (2023). Environmental Performance Feedback and Timing of Reshoring: Perspectives from the Behavioural Theory of the Firm. British Journal of Management, 34(3), 1238-1258. https://doi.org/10.1111/1467-8551.12677

The behavioural theory of the firm (BTOF) claims that firms’ performance feedback is significant for strategic decision‐making. Building upon this, we shift our focus from the widely researched topic of financial performance to sustainability perform... Read More about Environmental Performance Feedback and Timing of Reshoring: Perspectives from the Behavioural Theory of the Firm.

The impact of the COVID-19 pandemic on smoking, vaping and smoking cessation services in the UK: A qualitative study (2022)
Journal Article
Johnston, E., Bains, M., Hunter, A., & Langley, T. (2023). The impact of the COVID-19 pandemic on smoking, vaping and smoking cessation services in the UK: A qualitative study. Nicotine & Tobacco Research, 25(2), 339-344. https://doi.org/10.1093/ntr/ntac227

BACKGROUND: Existing evidence suggests that while the coronavirus disease 2019 (COVID-19) pandemic triggered quit attempts among many smokers, it led some to smoke more and others to relapse back to smoking. These diverse effects have the potential t... Read More about The impact of the COVID-19 pandemic on smoking, vaping and smoking cessation services in the UK: A qualitative study.

In silico evidence for the utility of parsimonious root phenotypes for improved vegetative growth and carbon sequestration under drought (2022)
Journal Article
Schäfer, E. D., Ajmera, I., Farcot, E., Owen, M. R., Band, L. R., & Lynch, J. P. (2022). In silico evidence for the utility of parsimonious root phenotypes for improved vegetative growth and carbon sequestration under drought. Frontiers in Plant Science, 13, Article 1010165. https://doi.org/10.3389/fpls.2022.1010165

Drought is a primary constraint to crop yields and climate change is expected to increase the frequency and severity of drought stress in the future. It has been hypothesized that crops can be made more resistant to drought and better able to sequest... Read More about In silico evidence for the utility of parsimonious root phenotypes for improved vegetative growth and carbon sequestration under drought.

Understanding students’ academic help-seeking on digital devices – a qualitative analysis (2022)
Journal Article
Schlusche, C., Schnaubert, L., & Bodemer, D. (2023). Understanding students’ academic help-seeking on digital devices – a qualitative analysis. Research and Practice in Technology Enhanced Learning, 18, Article 017. https://doi.org/10.58459/rptel.2023.18017

Undergraduate students are expected to regulate their learning processes and overcome knowledge-related obstacles. Academic help-seeking (HS) is a social strategy to acquire missing information or explanations. As mobile devices are a popular means f... Read More about Understanding students’ academic help-seeking on digital devices – a qualitative analysis.

Catalysis enabled synthesis, structures, and reactivities of fluorinated S8-corona[n]arenes (n = 8–12) (2022)
Journal Article
Turley, A. T., Hanson-Heine, M. W. D., Argent, S. P., Hu, Y., Jones, T. A., Fay, M., & Woodward, S. (2023). Catalysis enabled synthesis, structures, and reactivities of fluorinated S8-corona[n]arenes (n = 8–12). Chemical Science, 14(1), 70-77. https://doi.org/10.1039/d2sc05348a

Previously inaccessible large S8-corona[n]arene macrocycles (n = 8-12) with alternating aryl and 1,4-C6F4 subunits are easily prepared on up to gram scales, without the need for chromatography (up to 45% yield, 10 different examples) through new high... Read More about Catalysis enabled synthesis, structures, and reactivities of fluorinated S8-corona[n]arenes (n = 8–12).

Phospholenes from Phosphabenzenes by Selective Ring Contraction (2022)
Journal Article
Lin, J., Coles, N. T., Dettling, L., Steiner, L., Witte, J. F., Paulus, B., & Müller, C. (2022). Phospholenes from Phosphabenzenes by Selective Ring Contraction. Chemistry - A European Journal, 28(72), Article e202203406. https://doi.org/10.1002/chem.202203406

A 3-amino-functionalized phosphabenzene (phosphinine) has been synthesized and structurally characterized. The pyramidalized nitrogen atom of the dimethylamino substituent indicates only a weak interaction between the lone pair of the nitrogen atom a... Read More about Phospholenes from Phosphabenzenes by Selective Ring Contraction.

Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy (2022)
Journal Article
Ellwood, R. A., Slade, L., Lewis, J., Torregrossa, R., Sudevan, S., Piasecki, M., …Szewczyk, N. J. (2022). Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy. Communications Biology, 5(1), Article 1255. https://doi.org/10.1038/s42003-022-04212-z

Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), a common muscle disease that manifests with muscle weakness, wasting, and degeneration. An emerging theme in DMD pathophysiology is an intramuscular deficit in the gasotransmit... Read More about Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy.

Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease (2022)
Journal Article
Li, X., Li, T., Zhan, F., Cheng, F., Lu, L., Zhang, B., …Yao, H. (2022). Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease. ACS Chemical Neuroscience, 13(23), 3488-3501. https://doi.org/10.1021/acschemneuro.2c00520

Based on a multitarget strategy, a series of novel chromanone-1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation demonstrated that these hybrids exhibited signific... Read More about Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease.

Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study (2022)
Journal Article
Rodgers, S., Taylor, A. C., Roberts, S. A., Allen, T., Ashcroft, D. M., Barrett, J., …Avery, A. J. (2022). Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study. PLoS Medicine, 19(11), Article e1004133. https://doi.org/10.1371/journal.pmed.1004133

Background: We previously reported on a randomised trial demonstrating the effectiveness and cost-effectiveness of a pharmacist-led information technology intervention (PINCER). We sought to investigate whether PINCER was effective in reducing hazard... Read More about Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study.

Studying the aging of Laponite suspensions using extensional rheology (2022)
Journal Article
Hayes, M. J., & Smith, M. I. (2022). Studying the aging of Laponite suspensions using extensional rheology. European Physical Journal E, 45(11), Article 91. https://doi.org/10.1140/epje/s10189-022-00244-9

The effect of aging on the break-up dynamics of Laponite suspensions was studied in an extensional geometry. It was found that samples of increased age undergo stronger necking at the midpoint. The thinning of samples, driven purely by motion of the... Read More about Studying the aging of Laponite suspensions using extensional rheology.

Emergent quantum correlations and collective behavior in noninteracting quantum systems subject to stochastic resetting (2022)
Journal Article
Magoni, M., Carollo, F., Perfetto, G., & Lesanovsky, I. (2022). Emergent quantum correlations and collective behavior in noninteracting quantum systems subject to stochastic resetting. Physical Review A, 106(5), Article 052210. https://doi.org/10.1103/physreva.106.052210

We investigate the dynamics of a noninteracting spin system, undergoing coherent Rabi oscillations, in the presence of stochastic resetting. We show that resetting generally induces long-range quantum and classical correlations both in the emergent d... Read More about Emergent quantum correlations and collective behavior in noninteracting quantum systems subject to stochastic resetting.

Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter)-a randomised placebo-controlled feasibility trial (2022)
Journal Article
Bath, P. M., Skinner, C. J. C., Bath, C. S., Woodhouse, L. J., Areti, A., Korovesi, K., …Gordon, A. L. (2022). Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter)-a randomised placebo-controlled feasibility trial. European Geriatric Medicine, 13, 1343-1355. https://doi.org/10.1007/s41999-022-00714-5

Purpose
Infections cause considerable care home morbidity and mortality. Nitric oxide (NO) has broad-spectrum anti-viral, bacterial and yeast activity in vitro. We assessed the feasibility of supplementing dietary nitrate (NO substrate) intake in ca... Read More about Dietary nitrate supplementation for preventing and reducing the severity of winter infections, including COVID-19, in care homes (BEET-Winter)-a randomised placebo-controlled feasibility trial.

Mental health service provision for single homeless people: findings from a freedom of information-based study (2022)
Journal Article
Giles, E., Lucas, S., Archard, P. J., Moore, I., Tangen, J., O’Reilly, M., & Murphy, D. (2024). Mental health service provision for single homeless people: findings from a freedom of information-based study. Mental Health Practice, 27(3), Article e1630. https://doi.org/10.7748/mhp.2022.e1630

Background
Homeless people are at increased risk of developing mental health conditions and mental ill-health can be a precipitating factor for episodes of homelessness. However, gaps in mental health provision for homeless people remain, and they... Read More about Mental health service provision for single homeless people: findings from a freedom of information-based study.

Transcriptome analysis of differentially expressed circRNAs miRNAs and mRNAs during the challenge of coccidiosis (2022)
Journal Article
Chen, X., Wang, Z., Chen, Y., Akinci, I., Luo, W., Xu, Y., …Nie, Q. (2022). Transcriptome analysis of differentially expressed circRNAs miRNAs and mRNAs during the challenge of coccidiosis. Frontiers in Immunology, 13, Article 910860. https://doi.org/10.3389/fimmu.2022.910860

Avian coccidiosis is a common enzootic disease caused by infection of Eimeria species parasites. It causes huge economic losses in the global poultry industry. Current control using anticoccidial drugs or vaccination is limited due to drug resistance... Read More about Transcriptome analysis of differentially expressed circRNAs miRNAs and mRNAs during the challenge of coccidiosis.

Artificial Intelligence Systems, Responsibility and Agential Self-Awareness (2022)
Presentation / Conference Contribution
Farina, L. (2022). Artificial Intelligence Systems, Responsibility and Agential Self-Awareness. In V. C. Müller (Ed.), Philosophy and Theory of Artificial Intelligence 2021 (15-25). https://doi.org/10.1007/978-3-031-09153-7_2

This paper investigates the claim that artificial Intelligence Systems cannot be held morally responsible because they do not have an ability for agential self-awareness e.g. they cannot be aware that they are the agents of an action. The main sugges... Read More about Artificial Intelligence Systems, Responsibility and Agential Self-Awareness.

Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors (2022)
Presentation / Conference Contribution
Bishton, M., Crooks, C., Liu, H., Ban, L., Bythell, M., Card, T., …West, J. (2022). Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors. Blood, 140(Supplement 1), 2599-2600. https://doi.org/10.1182/blood-2022-158999

Background: Haemophagocytic Lymphohistiocytosis (HLH) is a rare, life-threatening hyper-inflammatory syndrome triggered by constitutive and acquired risk factors including haematological malignancy, infection, auto-immunity and rheumatological diseas... Read More about Haemphagocytic Lymphohistiocytosis in an English Nationwide Cohort Confirms Increasing Incidence and Variation in Trigger Factors.