All Outputs (43)

Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort (2020)
Working Paper
Jia, R., Knight, H., Blake, H., Corner, J., Denning, C., Ball, J., …Vedhara, K. Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort

Objective: This study examined the COVID-19 risk perceptions and mental health of university students on returning to campus in the midst of the COVID-19 pandemic. Methods: An online survey was completed during the first four weeks of the academic... Read More about Experiences of the COVID-19 pandemic: cross-sectional analysis of risk perceptions and mental health in a student cohort.

Lipid levels and major adverse cardiovascular events in patients initiated on statins for primary prevention: an international population-based cohort study protocol (2020)
Journal Article
Blais, J. E., Akyea, R. K., Coetzee, A., Chan, A. H., Lau, W. C., Man, K. K., …Weng, S. (2021). Lipid levels and major adverse cardiovascular events in patients initiated on statins for primary prevention: an international population-based cohort study protocol. BJGP Open, 5(1), 1-9. https://doi.org/10.3399/bjgpopen20X101127

Background: Clinical guidelines recommend specific targets for low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) for primary prevention of cardiovascular disease (CVD). Furthermore, individual variab... Read More about Lipid levels and major adverse cardiovascular events in patients initiated on statins for primary prevention: an international population-based cohort study protocol.

Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study (2020)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2021). Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study. British Journal of General Practice, 71(706), E364-E371. https://doi.org/10.3399/bjgp20X714137

Abstract Objective: To develop and validate a risk prediction equation to predict absolute risk of prostate cancer in asymptomatic men with prostate specific antigen (PSA) tests in primary care. Design: Open cohort study. Setting: Routine data from 1... Read More about Development and validation of a novel algorithm to estimate risk of developing prostate cancer in asymptomatic men: a cohort study.

Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis (2020)
Journal Article
Vedhara, K., Royal, S., Sunger, K., Caldwell, D. M., Halliday, V., Taylor, C. M., …Welton, N. J. (2021). Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis. Health Psychology Review, 15(2), 245-271. https://doi.org/10.1080/17437199.2020.1854050

© 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Psychological and behavioural may enhance vaccine effectiveness. We conducted a systematic review and network meta-analysis (NMA) to examine the effects of non-pharmacologi... Read More about Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis.

Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention (2020)
Journal Article
Claire, R., Gluud, C., Berlin, I., Coleman, T., & Leonardi-Bee, J. (2020). Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention. BMC Medical Research Methodology, 20(1), Article 284. https://doi.org/10.1186/s12874-020-01169-7

Background: Assessing benefits and harms of health interventions is resource-intensive and often requires feasibility and pilot trials followed by adequately powered randomised clinical trials. Data from feasibility and pilot trials are used to infor... Read More about Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention.

Identifying, managing and supporting patients with a rare disease (2020)
Journal Article
Evans, W., McKay, L., & Qureshi, N. (2021). Identifying, managing and supporting patients with a rare disease. InnovAiT, 14(2), 92-99. https://doi.org/10.1177/1755738020974411

Rare diseases (RDs) are defined as diseases that affect less than 1 in 2000 people, 71.9% are genetic and 69.9% have symptom onset in childhood. There are an estimated 8000 rare diseases, and although individually rare, collectively they are common,... Read More about Identifying, managing and supporting patients with a rare disease.

Incidence, nature and causes of avoidable significant harm in primary care in England: retrospective case note review (2020)
Journal Article
Avery, A. J., Sheehan, C. L., Bell, B. G., Armstrong, S. J., Ashcroft, D. M., Boyd, M. J., …Carson-Stevens, A. (2021). Incidence, nature and causes of avoidable significant harm in primary care in England: retrospective case note review. BMJ Quality and Safety, 30(12), 961-976. https://doi.org/10.1136/bmjqs-2020-011405

Objective To estimate the incidence of avoidable significant harm in primary care in England; describe and classify the associated patient safety incidents and generate suggestions to mitigate risks of ameliorable factors contributing to the incident... Read More about Incidence, nature and causes of avoidable significant harm in primary care in England: retrospective case note review.

Pregnant women’s use of e-cigarettes in the UK: a cross-sectional survey (2020)
Journal Article
Bowker, K., Lewis, S., Phillips, L., Orton, S., Ussher, M., Naughton, F., …Cooper, S. (2021). Pregnant women’s use of e-cigarettes in the UK: a cross-sectional survey. BJOG: An International Journal of Obstetrics and Gynaecology, 128(6), 984-993. https://doi.org/10.1111/1471-0528.16553

Objective: To estimate prevalence of vaping in pregnancy. Compare characteristics and attitudes between exclusive smokers and vapers, and between exclusive vapers and dual users (smoke and vape). Design: Cross-sectional survey. Setting: Hospitals acr... Read More about Pregnant women’s use of e-cigarettes in the UK: a cross-sectional survey.

Preventable medication harm across health care settings: a systematic review and meta-analysis (2020)
Journal Article
Hodkinson, A., Tyler, N., Ashcroft, D. M., Keers, R. N., Khan, K., Phipps, D., …Campbell, S. (2020). Preventable medication harm across health care settings: a systematic review and meta-analysis. BMC Medicine, 18(1), Article 313. https://doi.org/10.1186/s12916-020-01774-9

Background: Mitigating or reducing the risk of medication harm is a global policy priority. But evidence reflecting preventable medication harm in medical care and the factors that derive this harm remain unknown. Therefore, we aimed to quantify the... Read More about Preventable medication harm across health care settings: a systematic review and meta-analysis.

Seeing the Bigger Picture: Susceptibility to, and Detection of, Deception (2020)
Journal Article
Warren-West, L. S., & Jackson, R. C. (2020). Seeing the Bigger Picture: Susceptibility to, and Detection of, Deception. Journal of Sport and Exercise Psychology, 42(6), 463-471. https://doi.org/10.1123/jsep.2020-0040

An extended time window was used to examine susceptibility to, and detection of, deception in rugby union. High- and low-skilled rugby players judged the final running direction of an opponent “cutting” left or right, with or without a deceptive sides... Read More about Seeing the Bigger Picture: Susceptibility to, and Detection of, Deception.

Incident Type 2 Diabetes and Risk of Fracture: A Comparative Cohort Analysis Using U.K. Primary Care Records (2020)
Journal Article
Davie, G. S., Pal, K., Orton, E., Tyrrell, E. G., & Petersen, I. (2021). Incident Type 2 Diabetes and Risk of Fracture: A Comparative Cohort Analysis Using U.K. Primary Care Records. Diabetes Care, 44(1), 58-66. https://doi.org/10.2337/dc20-1220

Objective: To estimate risk of fracture in men and women with recent diagnosis of type 2 diabetes compared to individuals without diabetes. Research Design and Methods: In this cohort study we used routinely-collected UK primary care data from Th... Read More about Incident Type 2 Diabetes and Risk of Fracture: A Comparative Cohort Analysis Using U.K. Primary Care Records.

UK Research Priorities for Electronic Cigarettes: A James Lind Alliance Priority Setting Partnership (2020)
Journal Article
Hunter, A., Ross, L., Gronlund, T., & Cooper, S. (2020). UK Research Priorities for Electronic Cigarettes: A James Lind Alliance Priority Setting Partnership. International Journal of Environmental Research and Public Health, 17(22), 1-11. https://doi.org/10.3390/ijerph17228500

This study aimed to bring together people who smoke or vape, people who do not smoke and healthcare professionals to identify and agree priorities for electronic cigarette research in the UK. We carried out a priority setting partnership, guided by t... Read More about UK Research Priorities for Electronic Cigarettes: A James Lind Alliance Priority Setting Partnership.

Sex differences in cardiovascular morbidity associated with familial hypercholesterolaemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records (2020)
Journal Article
Iyen, B., Qureshi, N., Weng, S., Roderick, P., Kai, J., Capps, N., …Humphries, S. E. (2020). Sex differences in cardiovascular morbidity associated with familial hypercholesterolaemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records. Atherosclerosis, 315, 131-137. https://doi.org/10.1016/j.atherosclerosis.2020.10.895

Background and aims: The UK Simon Broome (SB) familial hypercholesterolaemia (FH) register previously reported 3-fold higher standardised mortality ratio for cardiovascular disease (CVD) in women compared to men from 2009 to 2015. Here we examined se... Read More about Sex differences in cardiovascular morbidity associated with familial hypercholesterolaemia: A retrospective cohort study of the UK Simon Broome register linked to national hospital records.

Young people, mental health and COVID-19 infection: The canaries we put in the coal-mine (2020)
Journal Article
Jia, R., Ayling, K., Chalder, T., Coupland, C., Massey, A., Broadbent, E., …Vedhara, K. (2020). Young people, mental health and COVID-19 infection: The canaries we put in the coal-mine. Public Health, 189, 158-161. https://doi.org/10.1016/j.puhe.2020.10.018

Background: The number of people testing positive for SARS-COV-2 in the UK, particularly among young adults, is increasing. We report here on the mental health of young adults and related psychological and behavioural responses to the pandemic, and c... Read More about Young people, mental health and COVID-19 infection: The canaries we put in the coal-mine.

Specialist recommendation for chemoprevention medications in patients at familial risk of breast cancer: a cross-sectional survey in England (2020)
Journal Article
Lee, S. I., Curtis, H., Qureshi, S., Dutton, B., & Qureshi, N. (2021). Specialist recommendation for chemoprevention medications in patients at familial risk of breast cancer: a cross-sectional survey in England. Journal of Community Genetics, 12(1), 111–120. https://doi.org/10.1007/s12687-020-00490-4

In England, the National Institute for Health and Care Excellence guideline for familial breast cancer recommends chemoprevention for women at high and moderate familial risk of breast cancer. However, prescribing of chemoprevention has not improved... Read More about Specialist recommendation for chemoprevention medications in patients at familial risk of breast cancer: a cross-sectional survey in England.

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases (2020)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2020). Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases. BMJ, 371, Article m3873. https://doi.org/10.1136/bmj.m3873

Objective: To assess breast cancer risks associated with different types and durations of hormone replacement therapy Design: Two nested case-control studies Setting: UK general practices contributing to QResearch or Clinical Practice Research... Read More about Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases.

Experts’ Views on Behaviour Change Techniques for Smoking Cessation in Pregnancy: A Qualitative Study (2020)
Journal Article
Abidi, F. B., Laing, L., Cooper, S., Coleman, T., & Campbell, K. A. (2020). Experts’ Views on Behaviour Change Techniques for Smoking Cessation in Pregnancy: A Qualitative Study. International Journal of Environmental Research and Public Health, 17(21), Article 7729. https://doi.org/10.3390/ijerph17217729

Smoking during pregnancy is a global health problem which has devastating health implications. Behavioural support is an important part of smoking cessation support for pregnant women. Research has identified barriers and facilitators (B&Fs) and effe... Read More about Experts’ Views on Behaviour Change Techniques for Smoking Cessation in Pregnancy: A Qualitative Study.

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study (2020)
Journal Article
Clift, A. K., Coupland, C. A., Keogh, R. H., Diaz-Ordaz, K., Williamson, E., Harrison, E. M., …Hippisley-Cox, J. (2020). Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study. BMJ, 371, Article m3731. https://doi.org/10.1136/bmj.m3731

Objective: To derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from coronavirus disease 2019 (covid-19) in adults. Design: Population based cohort study. Setting and participants: QResearch d... Read More about Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study.

An interview study of the experiences of cellulitis diagnosis amongst health care professionals (2020)
Journal Article
Patel, M., Ing Lee, S., Levell, N. J., Smart, P., Kai, J., Thomas, K. S., & Leighton, P. (2020). An interview study of the experiences of cellulitis diagnosis amongst health care professionals. BMJ Open, 10(10), Article e034692. https://doi.org/10.1136/+bmjopen-2019-034692

Objectives: To explore healthcare professionals (HCPs) experiences and challenges in diagnosing suspected lower limb cellulitis. Setting: UK nationwide. Participants: 20 qualified HCPs, who had a minimum of 2 years clinical experience as an HCP... Read More about An interview study of the experiences of cellulitis diagnosis amongst health care professionals.

Measuring physical activity levels in people with mild cognitive impairment or mild dementia (2020)
Journal Article
Van Der Wardt, V., Hancox, J. E., Burgon, C., Bajwa, R., Goldberg, S., & Harwood, R. H. (2021). Measuring physical activity levels in people with mild cognitive impairment or mild dementia. Journal of Aging and Physical Activity, 29(1), 10-16. https://doi.org/10.1123/japa.2019-0234

Measuring physical activity (PA) in people with mild cognitive impairment (MCI) or dementia can be difficult. The aim was to investigate the validity and acceptability of three different PA measurement methods. The mixed-method analysis included 49... Read More about Measuring physical activity levels in people with mild cognitive impairment or mild dementia.