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The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells (2020)
Journal Article
Brearley, M. C., Daniel, Z. C., Loughna, P. T., Parr, T., & Brameld, J. M. (2020). The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells. Scientific Reports, 10, Article 22177. https://doi.org/10.1038/s41598-020-79324-9

Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells... Read More about The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells.

A stable isotope approach to accurately determine iron and zinc bioaccessibility in cereals and legumes based on a modified INFOGEST static in vitro digestion method (2020)
Journal Article
Muleya, M., Young, S. D., & Bailey, E. H. (2021). A stable isotope approach to accurately determine iron and zinc bioaccessibility in cereals and legumes based on a modified INFOGEST static in vitro digestion method. Food Research International, 139, Article 109948. https://doi.org/10.1016/j.foodres.2020.109948

© 2020 Elsevier Ltd The establishment of the INFOGEST in vitro static digestion method, a standardized international consensus, was an important milestone in the field of food digestion. We evaluated the contribution of iron and zinc in reagents used... Read More about A stable isotope approach to accurately determine iron and zinc bioaccessibility in cereals and legumes based on a modified INFOGEST static in vitro digestion method.

Analysis of bovine blastocysts indicates ovarian stimulation does not induce chromosome errors, nor discordance between inner-cell mass and trophectoderm lineages (2020)
Journal Article
Tutt, D. A., Silvestri, G., Serrano-Albal, M., Simmons, R. J., Kwong, W. Y., Guven-Ates, G., …Sinclair, K. D. (2021). Analysis of bovine blastocysts indicates ovarian stimulation does not induce chromosome errors, nor discordance between inner-cell mass and trophectoderm lineages. Theriogenology, 161, 108-119. https://doi.org/10.1016/j.theriogenology.2020.11.021

© 2020 The Authors Contemporary systems for oocyte retrieval and culture of both cattle and human embryos are suboptimal with respect to pregnancy outcomes following transfer. In humans, chromosome abnormalities are the leading cause of early pregnan... Read More about Analysis of bovine blastocysts indicates ovarian stimulation does not induce chromosome errors, nor discordance between inner-cell mass and trophectoderm lineages.

Arabidopsis antibody resources for functional studies in plants (2020)
Journal Article
Oh, J., Wilson, M., Hill, K., Leftley, N., Hodgman, C., Bennett, M. J., & Swarup, R. (2020). Arabidopsis antibody resources for functional studies in plants. Scientific Reports, 10(1), Article 21945. https://doi.org/10.1038/s41598-020-78689-1

© 2020, The Author(s). Here we report creation of a unique and a very valuable resource for Plant Scientific community worldwide. In this era of post-genomics and modelling of multi-cellular systems using an integrative systems biology approach, bett... Read More about Arabidopsis antibody resources for functional studies in plants.

Understanding the lost functionality of ethanol in non-alcoholic beer using sensory evaluation, aroma release and molecular hydrodynamics (2020)
Journal Article
Ramsey, I., Dinu, V., Linforth, R., Yakubov, G. E., Harding, S. E., Yang, Q., …Fisk, I. (2020). Understanding the lost functionality of ethanol in non-alcoholic beer using sensory evaluation, aroma release and molecular hydrodynamics. Scientific Reports, 10(1), Article 20855. https://doi.org/10.1038/s41598-020-77697-5

© 2020, The Author(s). Consumer sensory evaluation, aroma release analysis and biophysical protein analysis were used to investigate the effect of ethanol on the release and perception of flavour in beer (lager and stout) at different ethanol levels... Read More about Understanding the lost functionality of ethanol in non-alcoholic beer using sensory evaluation, aroma release and molecular hydrodynamics.

Genome-wide association mapping for grain manganese in rice (Oryza sativa L.) using a multi-experiment approach (2020)
Journal Article
Ruang-areerate, P., Travis, A. J., Pinson, S. R. M., Tarpley, L., Eizenga, G. C., Guerinot, M. L., …Norton, G. J. (2021). Genome-wide association mapping for grain manganese in rice (Oryza sativa L.) using a multi-experiment approach. Heredity, 126(3), 505-520. https://doi.org/10.1038/s41437-020-00390-w

Manganese (Mn) is an essential trace element for plants and commonly contributes to human health; however, the understanding of the genes controlling natural variation in Mn in crop plants is limited. Here, the integration of two of genome-wide assoc... Read More about Genome-wide association mapping for grain manganese in rice (Oryza sativa L.) using a multi-experiment approach.

Thermal taster status: Temperature modulation of cortical response to sweetness perception (2020)
Journal Article
Eldeghaidy, S., Yang, Q., Abualait, T., Williamson, A., Hort, J., & Francis, S. T. (2021). Thermal taster status: Temperature modulation of cortical response to sweetness perception. Physiology and Behavior, 230, Article 113266. https://doi.org/10.1016/j.physbeh.2020.113266

© 2020 Temperature is known to impact taste perception, but its reported effect on sweet taste perception in humans is inconsistent. Here, we assess whether thermal taste phenotype alters the temperature modulation of the brains’ response to sweet sa... Read More about Thermal taster status: Temperature modulation of cortical response to sweetness perception.

Coordination between microbiota and root endodermis supports plant mineral nutrient homeostasis (2020)
Journal Article
Salas-González, I., Reyt, G., Flis, P., Custódio, V., Gopaulchan, D., Bakhoum, N., …Castrillo, G. (2021). Coordination between microbiota and root endodermis supports plant mineral nutrient homeostasis. Science, 371(6525), Article eabd0695. https://doi.org/10.1126/science.abd0695

Copyright © 2021, American Association for the Advancement of Science. Plant roots and animal guts have evolved specialized cell layers to control mineral nutrient homeostasis. These layers must tolerate the resident microbiota while keeping homeosta... Read More about Coordination between microbiota and root endodermis supports plant mineral nutrient homeostasis.

Persistent millennial-scale climate variability in Southern Europe during Marine Isotope Stage 6 (2020)
Journal Article
Wilson, G. P., Frogley, M. R., Hughes, P. D., Roucoux, K. H., Margari, V., Jones, T. D., …Tzedakis, P. C. (2021). Persistent millennial-scale climate variability in Southern Europe during Marine Isotope Stage 6. Quaternary Science Advances, 3, Article 100016. https://doi.org/10.1016/j.qsa.2020.100016

Exploring the mode and tempo of millennial-scale climate variability under evolving boundary conditions can provide insights into tipping points in different parts of the Earth system, and can facilitate a more detailed understanding of climate telec... Read More about Persistent millennial-scale climate variability in Southern Europe during Marine Isotope Stage 6.

Full species-wide leaf and seed ionomic diversity of Arabidopsis thaliana (2020)
Working Paper
Campos, A. C. A. L., van Dijk, W. F., Ramakrishna, P., Giles, T., Korte, P., Douglas, A., …Salt, D. E. Full species-wide leaf and seed ionomic diversity of Arabidopsis thaliana

• Soil is a heterogenous reservoir of essential elements needed for plant growth and development. Plants have evolved mechanisms to balance their nutritional needs based on availability of nutrients. This has led to genetically-based variation in the... Read More about Full species-wide leaf and seed ionomic diversity of Arabidopsis thaliana.

Novel sources of variation in grain yield, components and mineral traits identified in wheat amphidiploids derived from thinopyrum bessarabicum (Savul. & rayss) Á. löve (poaceae) under saline soils in India (2020)
Journal Article
Khokhar, J. S., Sareen, S., Tyagi, B. S., Wilson, L., Young, S., King, J., …Broadley, M. R. (2020). Novel sources of variation in grain yield, components and mineral traits identified in wheat amphidiploids derived from thinopyrum bessarabicum (Savul. & rayss) Á. löve (poaceae) under saline soils in India. Sustainability, 12(21), Article 8975. https://doi.org/10.3390/su12218975

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Salt-affected soils constrain wheat production globally. A wild wheat species, Thinopyrum bessarabicum (Savul. & Rayss) Á. Löve (Poaceae), and its derivatives are tolerant of high external NaC... Read More about Novel sources of variation in grain yield, components and mineral traits identified in wheat amphidiploids derived from thinopyrum bessarabicum (Savul. & rayss) Á. löve (poaceae) under saline soils in India.

Policy, toxicology and physicochemical considerations on the inhalation of high concentrations of food flavour (2020)
Journal Article
Dinu, V., Kilic, A., Wang, Q., Ayed, C., Fadel, A., Harding, S. E., …Fisk, I. D. (2020). Policy, toxicology and physicochemical considerations on the inhalation of high concentrations of food flavour. npj Science of Food, 4, Article 15. https://doi.org/10.1038/s41538-020-00075-y

© 2020, The Author(s). Food flavour ingredients are required by law to obtain prior approval from regulatory bodies, such as the U.S. Food and Drug Administration (FDA) or the European Food Safety Authority (EFSA) in terms of toxicological data and i... Read More about Policy, toxicology and physicochemical considerations on the inhalation of high concentrations of food flavour.

Deep drilling reveals massive shifts in evolutionary dynamics after formation of ancient ecosystem (2020)
Journal Article
Wilke, T., Hauffe, T., Jovanovska, E., Cvetkoska, A., Donders, T., Ekschmitt, K., …Wagner, B. (2020). Deep drilling reveals massive shifts in evolutionary dynamics after formation of ancient ecosystem. Science Advances, 6(40), Article eabb2943. https://doi.org/10.1126/sciadv.abb2943

The scarcity of high-resolution empirical data directly tracking diversity over time limits our understanding of speciation and extinction dynamics and the drivers of rate changes. Here, we analyze a continuous species-level fossil record of endemic... Read More about Deep drilling reveals massive shifts in evolutionary dynamics after formation of ancient ecosystem.

Effect of soil properties on time-dependent fixation (ageing) of selenate (2020)
Journal Article
Ramkissoon, C., Degryse, F., Young, S., Bailey, E. H., & McLaughlin, M. J. (2021). Effect of soil properties on time-dependent fixation (ageing) of selenate. Geoderma, 383, Article 114741. https://doi.org/10.1016/j.geoderma.2020.114741

© 2020 Elsevier B.V. Previous biofortification studies have established that the residual effect of added selenium (Se) fertilisers on second-season crops is minimal. To explore the fate of exogenous Se in soil, chemical and biological methods were e... Read More about Effect of soil properties on time-dependent fixation (ageing) of selenate.

Arabidopsis thaliana zinc accumulation in leaf trichomes is correlated with zinc concentration in leaves (2020)
Working Paper
Ricachenevsky, F. K., Punshon, T., Salt, D. E., Fett, J. P., & Guerinot, M. L. Arabidopsis thaliana zinc accumulation in leaf trichomes is correlated with zinc concentration in leaves

Zinc (Zn) is a key micronutrient. In humans, Zn deficiency is a common nutritional disorder, and most people acquire dietary Zn from eating plants. In plants, Zn deficiency can decrease plant growth and yield. Understanding Zn homeostasis in plants c... Read More about Arabidopsis thaliana zinc accumulation in leaf trichomes is correlated with zinc concentration in leaves.

Impact of neospora caninum infection on the bioenergetics and transcriptome of cerebrovascular endothelial cells (2020)
Journal Article
Elsheikha, H. M., Alkurashi, M., Palfreman, S., Castellanos, M., Kong, K., Ning, E., …MacNaughtan, W. (2020). Impact of neospora caninum infection on the bioenergetics and transcriptome of cerebrovascular endothelial cells. Pathogens, 9(9), Article 710. https://doi.org/10.3390/pathogens9090710

In this work, the effects of the protozoan Neospora caninum on the bioenergetics, chemical composition, and elemental content of human brain microvascular endothelial cells (hBMECs) were investigated. We showed that N. caninum can impair cell mitocho... Read More about Impact of neospora caninum infection on the bioenergetics and transcriptome of cerebrovascular endothelial cells.

Uclacyanin Proteins Are Required for Lignified Nanodomain Formation within Casparian Strips (2020)
Journal Article
Reyt, G., Chao, Z., Flis, P., Salas-González, I., Castrillo, G., Chao, D. Y., & Salt, D. E. (2020). Uclacyanin Proteins Are Required for Lignified Nanodomain Formation within Casparian Strips. Current Biology, 30(20), 4103-4111.e6. https://doi.org/10.1016/j.cub.2020.07.095

© 2020 The Author(s) Casparian strips (CSs) are cell wall modifications of vascular plants restricting extracellular free diffusion into and out of the vascular system [1]. This barrier plays a critical role in controlling the acquisition of nutrient... Read More about Uclacyanin Proteins Are Required for Lignified Nanodomain Formation within Casparian Strips.

Increased expression of the HvMALE STERILITY1 Transcription Factor Results in Temperature-Sensitive Male Sterility in Barley (2020)
Journal Article
Fernandez Gomez, J., Talle, B., & Wilson, Z. (2020). Increased expression of the HvMALE STERILITY1 Transcription Factor Results in Temperature-Sensitive Male Sterility in Barley. Journal of Experimental Botany, 71(20), 6328–6339. https://doi.org/10.1093/jxb/eraa382

Understanding the control of fertility is critical for crop yield and breeding, this is particularly important for hybrid breeding to capitalise upon the resultant hybrid vigour. Different hybrid breeding systems have been adopted, however these are... Read More about Increased expression of the HvMALE STERILITY1 Transcription Factor Results in Temperature-Sensitive Male Sterility in Barley.