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Fourier domain diffuse correlation spectroscopy with heterodyne holographic detection (2020)
Journal Article
James, E., & Powell, S. (2020). Fourier domain diffuse correlation spectroscopy with heterodyne holographic detection. Biomedical Optics Express, 11(11), 6755-6779. https://doi.org/10.1364/boe.400525

We present a new approach to diffuse correlation spectroscopy which overcomes the limited light throughput of single-mode photon counting techniques. Our system employs heterodyne holographic detection to allow parallel measurement of the power spect... Read More about Fourier domain diffuse correlation spectroscopy with heterodyne holographic detection.

Functional imaging of the developing brain with wearable high-density diffuse optical tomography: a new benchmark for infant neuroimaging outside the scanner environment (2020)
Journal Article
Frijia, E. M., Billing, A., Lloyd-Fox, S., Rosas, E. V., Collins-Jones, L., Crespo-Llado, M. M., …Cooper, R. J. (2021). Functional imaging of the developing brain with wearable high-density diffuse optical tomography: a new benchmark for infant neuroimaging outside the scanner environment. NeuroImage, 225, Article 117490. https://doi.org/10.1016/j.neuroimage.2020.117490

Studies of cortical function in the awake infant are extremely challenging to undertake with traditional neuroimaging approaches. Partly in response to this challenge, functional near-infrared spectroscopy (fNIRS) has become increasingly common in de... Read More about Functional imaging of the developing brain with wearable high-density diffuse optical tomography: a new benchmark for infant neuroimaging outside the scanner environment.

Efficient inversion strategies for estimating optical properties with Monte Carlo radiative transport models (2020)
Journal Article
Macdonald, C. M., Arridge, S., & Powell, S. (2020). Efficient inversion strategies for estimating optical properties with Monte Carlo radiative transport models. Journal of Biomedical Optics, 25(08), https://doi.org/10.1117/1.jbo.25.8.085002

Significance: Indirect imaging problems in biomedical optics generally require repeated evaluation of forward models of radiative transport, for which Monte Carlo is accurate yet computationally costly. We develop an approach to reduce this bottlene... Read More about Efficient inversion strategies for estimating optical properties with Monte Carlo radiative transport models.

A wide field-of-view, modular, high-density diffuse optical tomography system for minimally constrained three-dimensional functional neuroimaging (2020)
Journal Article
Zhao, H., Brigadoi, S., Chitnis, D., Vita, E. D., Castellaro, M., Powell, S., …Cooper, R. J. (2020). A wide field-of-view, modular, high-density diffuse optical tomography system for minimally constrained three-dimensional functional neuroimaging. Biomedical Optics Express, 11(8), 4110-4129. https://doi.org/10.1364/BOE.394914

The ability to produce high-quality images of human brain function in any environment and during unconstrained movement of the subject has long been a goal of neuroimaging research. Diffuse optical tomography, which uses the intensity of back-scatter... Read More about A wide field-of-view, modular, high-density diffuse optical tomography system for minimally constrained three-dimensional functional neuroimaging.

Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses (2020)
Journal Article
Papadimitriou, K. I., Vidal Rosas, E. E., Zhang, E., Cooper, R. J., Hebden, J. C., Arridge, S. R., & Powell, S. (2020). Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses. Biomedical Optics Express, 11(7), 3477-3490. https://doi.org/10.1364/boe.393586

Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typi... Read More about Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses.

Quantitative PA tomography of high resolution 3-D images: Experimental validation in a tissue phantom (2020)
Journal Article
Laufer, J., Prohaska, S., Powell, S., Buchmann, J., & Kaplan, B. (2020). Quantitative PA tomography of high resolution 3-D images: Experimental validation in a tissue phantom. Photoacoustics, 17, https://doi.org/10.1016/j.pacs.2019.100157

© 2019 The Author(s) Quantitative photoacoustic tomography aims to recover the spatial distribution of absolute chromophore concentrations and their ratios from deep tissue, high-resolution images. In this study, a model-based inversion scheme based... Read More about Quantitative PA tomography of high resolution 3-D images: Experimental validation in a tissue phantom.