Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission

Le Roch, Karine G.; Holder, Anthony A.; Bottrill, Andrew R.; Stanway, Rebecca R.; Wall, Richard J.; Tewari, Rita; Pandey, Rajan; Abel, Steven; Boucher, Matthew; Zeeshan, Mohammad; Wheatley, Sally; Batugedara, Gayani; Hollin, Thomas; Daniel, Emilie; Rea, Edward; Freville, Aline; Lu, Xueqing Maggie; Gupta, Dinesh; Brady, Declan

doi:10.1016/j.celrep.2020.01.033

All Outputs (3)

Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy (2020)
Journal Article
Townley, A., & Wheatley, S. P. (2020). Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy. Journal of Cell Science, 133(21), Article jcs247379. https://doi.org/10.1242/jcs.247379

Survivin is a cancer-associated protein that is pivotal for cellular life and death: it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria, the function of which rema... Read More about Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy.

Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy. (2020)
Other
Wheatley, S., & Townley, A. R. Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy

Survivin is a cancer-associated protein that is pivotal for cellular life and death: it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria, the function of which rema... Read More about Mitochondrial survivin reduces oxidative phosphorylation in cancer cells by inhibiting mitophagy..

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission (2020)
Journal Article
Le Roch, K. G., Holder, A. A., Bottrill, A. R., Stanway, R. R., Wall, R. J., Tewari, R., …Brady, D. (2020). Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission. Cell Reports, 30(6), 1883-1897.e6. https://doi.org/10.1016/j.celrep.2020.01.033

Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear. Here we examine... Read More about Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.