All Outputs (5)

Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates (2020)
Journal Article
Burgess, L., Wilson, H., Jones, A. R., Harvey, P., Natrajan, L., & Hay, S. (2020). Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates. Chemistry - A European Journal, 26(65), 14817-14822. https://doi.org/10.1002/chem.202001974

Upconverting phosphors (UCPs) convert multiple low energy photons into higher energy emission via the process of photon upconversion and offer an attractive alternative to organic fluorophores for use as luminescent probes. Here, UCPs were capped wit... Read More about Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates.

Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems (2020)
Journal Article
Nguyen, H. V., Detappe, A., Harvey, P., Gallagher, N., Mathieu, C., Agius, M. P., …Johnson, J. A. (2020). Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems. Polymer Chemistry, 11(29), 4768-4779. https://doi.org/10.1039/d0py00558d

Nitroxide-based organic-radical contrast agents (ORCAs) are promising as safe next-generation magnetic resonance imaging (MRI) tools. Nevertheless, stimuli-responsive ORCAs that enable MRI monitoring of prodrug activation have not been reported; such... Read More about Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems.

Metal-based imaging agents: progress towards interrogating neurodegenerative disease (2020)
Journal Article
Sedgwick, A. C., Brewster, J. T., Harvey, P., Iovan, D. A., Smith, G., He, X., …James, T. D. (2020). Metal-based imaging agents: progress towards interrogating neurodegenerative disease. Chemical Society Reviews, 2020(10), 2886-2915. https://doi.org/10.1039/c8cs00986d

Central nervous system (CNS) neurodegeneration is defined by a complex series of pathological processes that ultimately lead to death. The precise etiology of these disorders remains unknown. Recent efforts show that a mechanistic understanding of th... Read More about Metal-based imaging agents: progress towards interrogating neurodegenerative disease.

Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease (2020)
Journal Article
Brewster II, J. T., Thiabaud, G. D., Harvey, P., Zafar, H., Reuther, J. F., Dell'Acqua, S., …Sessler, J. L. (2020). Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease. Chem, 6(3), 703-724. https://doi.org/10.1016/j.chempr.2019.12.016

The complex etiology of neurodegeneration continues to stifle efforts to develop effective therapeutics. New agents elucidating key pathways causing neurodegeneration might serve to increase our understanding and potentially lead to improved treatmen... Read More about Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease.

Image-guided neural activity manipulation with a paramagnetic drug (2020)
Journal Article
Bricault, S., Barandov, A., Harvey, P., DeTienne, E., Hai, A., & Jasanoff, A. (2020). Image-guided neural activity manipulation with a paramagnetic drug. Nature Communications, 11(1), Article 136. https://doi.org/10.1038/s41467-019-13933-5

© 2020, The Author(s). Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of th... Read More about Image-guided neural activity manipulation with a paramagnetic drug.