All Outputs (16)

Discovery of a Novel Polymer for Xeno-Free, Long-Term Culture of Human Pluripotent Stem Cell Expansion (2020)
Journal Article
Nasir, A., Thorpe, J., Burroughs, L., Meurs, J., Pijuan‐Galito, S., Irvine, D. J., …Denning, C. (2020). Discovery of a Novel Polymer for Xeno-Free, Long-Term Culture of Human Pluripotent Stem Cell Expansion. Advanced Healthcare Materials, 10(6), Article 2001448. https://doi.org/10.1002/adhm.202001448

Human pluripotent stem cells (hPSCs) can be expanded and differentiated in vitro into almost any adult tissue cell type, and thus have great potential as a source for cell therapies with biomedical application. In this study, a fully-defined polymer... Read More about Discovery of a Novel Polymer for Xeno-Free, Long-Term Culture of Human Pluripotent Stem Cell Expansion.

Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs) (2020)
Journal Article
Blok, A. J., Gurnani, P., Xenopoulos, A., Burroughs, L., Duncan, J., Urbanowicz, R. A., …Alexander, M. R. (2020). Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs). Biointerphases, 15, Article 061005. https://doi.org/10.1116/6.0000586

The emergence of SARS-CoV-2 highlights the global need for platform technologies to enable rapid development of diagnostics, vaccines, treatments, and personal protective equipment (PPE). However, many current technologies require the detailed mechan... Read More about Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs).

Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling (2020)
Journal Article
Kotowska, A. M., Trindade, G. F., Mendes, P. M., Williams, P. M., Aylott, J. W., Shard, A. G., …Scurr, D. J. (2020). Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling. Nature Communications, 11(1), Article 5832. https://doi.org/10.1038/s41467-020-19445-x

Label-free protein characterization at surfaces is commonly achieved using digestion and/or matrix application prior to mass spectrometry. We report the assignment of undigested proteins at surfaces in situ using secondary ion mass spectrometry (SIMS... Read More about Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling.

Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (2020)
Journal Article
Blok, A. J., Gurnani, P., Xenopoulos, A., Burroughs, L., Duncan, J., Urbanowicz, R. A., …Alexander, M. R. (2020). Polymer microarrays rapidly identify competitive adsorbents of virus-like particles. Biointerphases, 15(6), Article 061005. https://doi.org/10.1116/6.0000586

The emergence of SARS-CoV-2 highlights the global need for platform technologies to enable the rapid development of diagnostics, vaccines, treatments, and personal protective equipment (PPE). However, many current technologies require the detailed me... Read More about Polymer microarrays rapidly identify competitive adsorbents of virus-like particles.

Single-Cell Tracking on Polymer Microarrays Reveals the Impact of Surface Chemistry on Pseudomonas aeruginosa Twitching Speed and Biofilm Development (2020)
Journal Article
Carabelli, A. M., Isgró, M., Sanni, O., Figueredo, G. P., Winkler, D. A., Burroughs, L., …Alexander, M. R. (2020). Single-Cell Tracking on Polymer Microarrays Reveals the Impact of Surface Chemistry on Pseudomonas aeruginosa Twitching Speed and Biofilm Development. ACS Applied Bio Materials, 3(12), 8471–8480. https://doi.org/10.1021/acsabm.0c00849

© 2020 American Chemical Society. Bacterial biofilms exhibit up to 1000 times greater resistance to antibiotic or host immune clearance than planktonic cells. Pseudomonas aeruginosa produces retractable type IV pili (T4P) that facilitate twitching mo... Read More about Single-Cell Tracking on Polymer Microarrays Reveals the Impact of Surface Chemistry on Pseudomonas aeruginosa Twitching Speed and Biofilm Development.

Spatially Resolved Molecular Compositions of Insoluble Multilayer Deposits Responsible for Increased Pollution from Internal Combustion Engines (2020)
Journal Article
Edney, M. K., Lamb, J. S., Spanu, M., Smith, E. F., Steer, E., Wilmot, E., …Scurr, D. J. (2020). Spatially Resolved Molecular Compositions of Insoluble Multilayer Deposits Responsible for Increased Pollution from Internal Combustion Engines. ACS Applied Materials and Interfaces, 12(45), 51026-51035. https://doi.org/10.1021/acsami.0c14532

Internal combustion engines are used heavily in diverse applications worldwide. Achieving the most efficient operation is key to improving air quality as society moves to a decarbonized energy system. Insoluble deposits that form within internal comb... Read More about Spatially Resolved Molecular Compositions of Insoluble Multilayer Deposits Responsible for Increased Pollution from Internal Combustion Engines.

Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering (2020)
Journal Article
Amer, M. H., Alvarez-Paino, M., McLaren, J., Pappalardo, F., Trujillo, S., Wong, J. Q., …Rose, F. R. (2021). Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering. Biomaterials, 266, Article 120450. https://doi.org/10.1016/j.biomaterials.2020.120450

© 2020 The Authors Mesenchymal stem cells are the focus of intense research in bone development and regeneration. The potential of microparticles as modulating moieties of osteogenic response by utilizing their architectural features is demonstrated... Read More about Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering.

All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2 (2020)
Journal Article
Xue, X., Ball, J. K., Alexander, C., & Alexander, M. R. (2020). All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2. Matter, 3(5), 1433-1441. https://doi.org/10.1016/j.matt.2020.10.006

© 2020 Elsevier Inc. The world faces a severe and acute public health emergency due to the ongoing coronavirus disease 2019 (COVID-19) global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Healthcare workers are... Read More about All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2.

Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties (2020)
Journal Article
Alobaid, M. A., Richards, S., Alexander, M. R., Gibson, M. I., & Ghaemmaghami, A. M. (2020). Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties. Materials Today Bio, 8, https://doi.org/10.1016/j.mtbio.2020.100080

© 2020 The Authors New strategies for immune modulation have shown real promise in regenerative medicine as well as the fight against autoimmune diseases, allergies, and cancer. Dendritic cells (DCs) are gatekeepers of the immune system and their abi... Read More about Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties.

Discovery of hemocompatible bacterial biofilm-resistant copolymers (2020)
Journal Article
Singh, T., Hook, A. L., Luckett, J., Maitz, M. F., Sperling, C., Werner, C., …Alexander, M. R. (2020). Discovery of hemocompatible bacterial biofilm-resistant copolymers. Biomaterials, 260, Article 120312. https://doi.org/10.1016/j.biomaterials.2020.120312

© 2020 The Authors Blood-contacting medical devices play an important role within healthcare and are required to be biocompatible, hemocompatible and resistant to microbial colonization. Here we describe a high throughput screen for copolymers with t... Read More about Discovery of hemocompatible bacterial biofilm-resistant copolymers.

Achieving Microparticles with Cell-Instructive Surface Chemistry by Using Tunable Co-Polymer Surfactants (2020)
Journal Article
Dundas, A. A., Cuzzucoli Crucitti, V., Haas, S., Dubern, J., Latif, A., Romero, M., …Irvine, D. J. (2020). Achieving Microparticles with Cell-Instructive Surface Chemistry by Using Tunable Co-Polymer Surfactants. Advanced Functional Materials, 30(36), https://doi.org/10.1002/adfm.202001821

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A flow-focusing microfluidic device is used to produce functionalized monodisperse polymer particles with surface chemistries designed to control bacterial biofilm formatio... Read More about Achieving Microparticles with Cell-Instructive Surface Chemistry by Using Tunable Co-Polymer Surfactants.

Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration (2020)
Journal Article
Vallieres, C., Hook, A. L., He, Y., Crucitti, V. C., Figueredo, G., Davies, C. R., …Avery, S. V. (2020). Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration. Science Advances, 6(23), Article eaba6574. https://doi.org/10.1126/sciadv.aba6574

© 2020 The Authors. Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passivel... Read More about Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration.

Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo (2020)
Journal Article
Rostam, H. M., Fisher, L. E., Hook, A. L., Burroughs, L., Luckett, J. C., Figueredo, G. P., …Ghaemmaghami, A. M. (2020). Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo. Matter, 2(6), 1564-1581. https://doi.org/10.1016/j.matt.2020.03.018

© 2020 The Author(s) Implantation of medical devices can result in inflammation. A large library of polymers is screened, and a selection found to promote macrophage differentiation towards pro- or anti-inflammatory phenotypes. The bioinstructive pro... Read More about Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo.

Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation (2020)
Journal Article
Vassey, M. J., Figueredo, G. P., Scurr, D. J., Vasilevich, A. S., Vermeulen, S., Carlier, A., …Alexander, M. R. (2020). Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation. Advanced Science, 7(11), https://doi.org/10.1002/advs.201903392

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Macrophages play a central role in orchestrating immune responses to foreign materials, which are often responsible for the failure of implanted medical devices. Material t... Read More about Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation.

ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray (2020)
Journal Article
Gardner, W., Hook, A. L., Alexander, M. R., Ballabio, D., Cutts, S. M., Muir, B. W., & Pigram, P. J. (2020). ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray. Analytical Chemistry, 92(9), 6587-6597. https://doi.org/10.1021/acs.analchem.0c00349

© 2020 American Chemical Society. Combinatorial approaches to materials discovery offer promising potential for the rapid development of novel polymer systems. Polymer microarrays enable the high-throughput comparison of material physical and chemica... Read More about ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray.

Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections (2020)
Journal Article
Kurmoo, Y., Hook, A. L., Harvey, D., Dubern, J., Williams, P., Morgan, S. P., …Alexander, M. R. (2020). Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections. Biomaterials Science, 8(5), 1464-1477. https://doi.org/10.1039/c9bm00875f

Real time monitoring of bacterial attachment to medical devices provides opportunities to detect early biofilm formation and instigate appropriate interventions before infection develops. This study utilises long period grating (LPG) optical fibre se... Read More about Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections.