All Outputs (4)

A Mechanistic Investigation into Ischemia-Driven Distal Recurrence of Glioblastoma (2020)
Journal Article
Curtin, L., Hawkins-Daarud, A., Porter, A. B., van der Zee, K. G., Owen, M. R., & Swanson, K. R. (2020). A Mechanistic Investigation into Ischemia-Driven Distal Recurrence of Glioblastoma. Bulletin of Mathematical Biology, 82(11), Article 143. https://doi.org/10.1007/s11538-020-00814-y

Glioblastoma (GBM) is the most aggressive primary brain tumor with a short median survival. Tumor recurrence is a clinical expectation of this disease and usually occurs along the resection cavity wall. However, previous clinical observations have su... Read More about A Mechanistic Investigation into Ischemia-Driven Distal Recurrence of Glioblastoma.

Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations (2020)
Journal Article
Morris, B., Curtin, L., Hawkins-Daarud, A., Hubbard, M. E., Rahman, R., Smith, S. J., …Owen, M. R. (2020). Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations. Mathematical Biosciences and Engineering, 17(5), 4905-4941. https://doi.org/10.3934/mbe.2020267

Glioblastomas (GBMs) are the most aggressive primary brain tumours and have no known cure. Each individual tumour comprises multiple sub-populations of genetically-distinct cells that may respond differently to targeted therapies and may contribute t... Read More about Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations.

Switching behaviour in vascular smooth muscle cell–matrix adhesion during oscillatory loading (2020)
Journal Article
Irons, L., Huang, H., Owen, M. R., O'Dea, R. D., Meininger, G. A., & Brook, B. S. (2020). Switching behaviour in vascular smooth muscle cell–matrix adhesion during oscillatory loading. Journal of Theoretical Biology, 502, Article 110387. https://doi.org/10.1016/j.jtbi.2020.110387

Integrins regulate mechanotransduction between smooth muscle cells (SMCs) and the extracellular matrix (ECM). SMCs resident in the walls of airways or blood vessels are continuously exposed to dynamic mechanical forces due to breathing or pulsatile b... Read More about Switching behaviour in vascular smooth muscle cell–matrix adhesion during oscillatory loading.

Speed Switch in Glioblastoma Growth Rate due to Enhanced Hypoxia-Induced Migration (2020)
Journal Article
Curtin, L., Hawkins-Daarud, A., van der Zee, K. G., Swanson, K. R., & Owen, M. R. (2020). Speed Switch in Glioblastoma Growth Rate due to Enhanced Hypoxia-Induced Migration. Bulletin of Mathematical Biology, 82(3), Article 43. https://doi.org/10.1007/s11538-020-00718-x

We analyze the wave-speed of the Proliferation Invasion Hypoxia Necro-sis Angiogenesis (PIHNA) model that was previously created and applied to simulate the growth and spread of glioblastoma (GBM), a particularly aggressive primary brain tumor. We ex... Read More about Speed Switch in Glioblastoma Growth Rate due to Enhanced Hypoxia-Induced Migration.