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A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes (2020)
Journal Article
Ramzan, I., Taylor, M., Phillips, B., Wilkinson, D., Smith, K., Hession, K., …Atherton, P. (2021). A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes. Nutrients, 13(1), Article 95. https://doi.org/10.3390/nu13010095

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Elevated circulating branched-chain amino acids (BCAAs; isoleucine, leucine, and valine) are associated with obesity and type 2 diabetes (T2D). Reducing circulatory BCAAs by dietary restrictio... Read More about A novel dietary intervention reduces circulatory branched-chain amino acids by 50%: A pilot study of relevance for obesity and diabetes.

Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells (2020)
Journal Article
Crossland, H., Smith, K., Idris, I., Phillips, B. E., Atherton, P. J., & Wilkinson, D. J. (2021). Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells. Experimental Physiology, 106(3), 585-592. https://doi.org/10.1113/EP089223

New Findings: What is the central question of this study? The compound sodium phenylbutyrate (PB) has been shown to promote branched-chain amino acid (BCAA) catabolism, and as such has been proposed as a treatment for disorders with enhanced BCAA lev... Read More about Phenylbutyrate, a branched-chain amino acid keto dehydrogenase activator, promotes branched-chain amino acid metabolism and induces muscle catabolism in C2C12 cells.

The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo (2020)
Journal Article
Bass, J. J., Kazi, A. A., Deane, C. S., Nakhuda, A., Ashcroft, S. P., Brook, M. S., …Atherton, P. J. (2021). The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo. Journal of Physiology, 599(3), 963-979. https://doi.org/10.1113/JP280652

Key points: Reduced vitamin D receptor (VDR) expression prompts skeletal muscle atrophy. Atrophy occurs through catabolic processes, namely the induction of autophagy, while anabolism remains unchanged. In response to VDR-knockdown mitochondrial func... Read More about The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo.

Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age (2020)
Journal Article
Sayda, M. H., Phillips, B. E., Williams, J. P., Greenhaff, P. L., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2020). Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age. Nutrients, 12(10), https://doi.org/10.3390/nu12103029

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support and regulation of tissue protein regulation and also as energy substrates. However, p... Read More about Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age.

Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle (2020)
Journal Article
Abdulla, H., Phillips, B. E., Wilkinson, D. J., Limb, M., Jandova, T., Bass, J. J., …Atherton, P. J. (2020). Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle. Aging Cell, 19(9), Article e13202. https://doi.org/10.1111/acel.13202

© 2020 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd Background: Despite its known insulin-independent effects, glucagon-like peptide-1 (GLP-1) role in muscle protein turnover has not been explored under fed-stat... Read More about Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.

Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing (2020)
Journal Article
Wilkinson, D. J., Rodriguez-Blanco, G., Dunn, W. B., Phillips, B. E., Williams, J. P., Greenhaff, P. L., …Atherton, P. J. (2020). Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing. Aging, 12(13), 12517-12533. https://doi.org/10.18632/aging.103513

Ageing compromises skeletal muscle mass and function through poorly defined molecular aetiology. Here we have used untargeted metabolomics using UHPLC-MS to profile muscle tissue from young (n=10, 25±4y), middle aged (n=18, 50±4y) and older (n=18, 70... Read More about Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing.

Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes (2020)
Journal Article
Crossland, H., Piasecki, J., McCormick, D., Phillips, B. E., Wilkinson, D. J., Smith, K., …Atherton, P. J. (2020). Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes. AJP - Regulatory, Integrative and Comparative Physiology, 319(2), R184-R194. https://doi.org/10.1152/ajpregu.00110.2020

Recent large genome-wide association studies (GWAS) have independently identified a set of genetic loci associated with lean body mass (LBM) and handgrip strength (HGS). Evaluation of these candidate single nucleotide polymorphisms (SNPs) may be usef... Read More about Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes.

The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men (2020)
Journal Article
Davies, R. W., Bass, J. J., Carson, B. P., Norton, C., Kozior, M., Wilkinson, D. J., …Jakeman, P. M. (2020). The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men. Nutrients, 12(3), Article 845. https://doi.org/10.3390/nu12030845

Background: The aim of this study was to investigate the effect of whey protein supplementation on myofibrillar protein synthesis (myoPS) and muscle recovery over a 7-d period of intensified resistance training (RT). Methods: In a double-blind random... Read More about The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men.

High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial (2020)
Journal Article
Blackwell, J. E. M., Doleman, B., Boereboom, C. L., Morton, A., Williams, S., Atherton, P., …Lund, J. N. (2020). High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial. Prostate Cancer and Prostatic Diseases, 23, 696–704. https://doi.org/10.1038/s41391-020-0219-1

Objectives To assess the efficacy of high-intensity interval training (HIIT) for improving cardiorespiratory fitness (CRF) in patients awaiting resection for urological malignancy within four weeks. Subjects/patients and methods A randomised... Read More about High-intensity interval training produces a significant improvement in fitness in less than 31 days before surgery for urological cancer: a randomised control trial.

A novel stable isotope tracer method to simultaneously quantify skeletal muscle protein synthesis and breakdown (2020)
Journal Article
Atherton, P. J., Crossland, H., Smith, K., Atherton, P. J., & Wilkinson, D. J. (2020). A novel stable isotope tracer method to simultaneously quantify skeletal muscle protein synthesis and breakdown. Metabolism Open, 5, https://doi.org/10.1016/j.metop.2020.100022

Background/Aims: Methodological challenges have been associated with the dynamic measurement of muscle protein breakdown (MPB), as have the measurement of both muscle protein synthesis (MPS) and MPB within the same experiment. Our aim was to use the... Read More about A novel stable isotope tracer method to simultaneously quantify skeletal muscle protein synthesis and breakdown.

Network analysis of human muscle adaptation to aging and contraction (2020)
Journal Article
Etheridge, T., Willis, C., Atherton, P., Ames, R., Szewczyk, N., Deane, C., …Lund, J. (2020). Network analysis of human muscle adaptation to aging and contraction. Aging, 12(1), 740-755. https://doi.org/10.18632/aging.102653

Resistance exercise (RE) remains a primary approach for minimising aging muscle decline. Understanding muscle adaptation to individual contractile components of RE (eccentric, concentric) might optimise RE-based intervention strategies. Herein, we em... Read More about Network analysis of human muscle adaptation to aging and contraction.