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All Outputs (6)

The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ (2020)
Journal Article
Miligy, I. M., Toss, M. S., Shiino, S., Oni, G., Syed, B. M., Khout, H., …Rakha, E. A. (2020). The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ. British Journal of Cancer, 123(10), 1513-1520. https://doi.org/10.1038/s41416-020-1023-3

Background: Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we investigated the value of ER expression in ductal carcinoma in situ (DCIS) in terms of out... Read More about The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ.

Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival (2020)
Journal Article
Joseph, C., Alsaleem, M., Orah, N., Narasimha, P. L., Miligy, I. M., Kurozumi, S., …Rakha, E. A. (2020). Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. Breast Cancer Research and Treatment, 182, 267–282. https://doi.org/10.1007/s10549-020-05670-x

Purpose: MMP9 is a matricellular protein associated with extracellular matrix (ECM) remodelling, that promotes tumour progression, and modulates the activity of cell adhesion molecules and cytokines. This study aims to assess the prognostic value of... Read More about Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival.

Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer (2020)
Journal Article
Aljohani, A. I., Joseph, C., Kurozumi, S., Mohammed, O. J., Miligy, I. M., Green, A. R., & Rakha, E. (2020). Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer. Breast Cancer Research and Treatment, 181(3), 541-551. https://doi.org/10.1007/s10549-020-05646-x

Background: Breast cancer (BC) is a disease with variable morphology, clinical behaviour and response to therapy. Identifying factors associated with the progression of early stage BC can help understand the risk of metastasis and guide treatment dec... Read More about Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer.

The prognostic significance of immune microenvironment in breast ductal carcinoma in situ (2020)
Journal Article
Toss, M. S., Abidi, A., Lesche, D., Joseph, C., Mahale, S., Saunders, H., …Rakha, E. A. (2020). The prognostic significance of immune microenvironment in breast ductal carcinoma in situ. British Journal of Cancer, 122, 1496–1506. https://doi.org/10.1038/s41416-020-0797-7

Background The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpo... Read More about The prognostic significance of immune microenvironment in breast ductal carcinoma in situ.

The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma (2020)
Journal Article
Thio, N., Kader, T., Elder, K., Zethoven, M., Semple, T., Hill, P., …Gorringe, K. L. (2020). The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma. npj Breast Cancer, 6, Article 9. https://doi.org/10.1038/s41523-020-0150-6

Intra-ductal papillomas (IDP) are challenging breast findings because of their variable risk of progression to malignancy. The molecular events driving IDP development and genomic features of malignant progression are poorly understood. In this study... Read More about The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma.