Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium

Portelli, Michael A.; Dijk, F. Nicole; Ketelaar, Maria E.; Shrine, Nick; Hankinson, Jenny; Bhaker, Sangita; Grotenboer, N�omi S.; Obeidat, Ma�en; Henry, Amanda P.; Billington, Charlotte K.; Shaw, Dominick; Johnson, Simon R.; Pogson, Zara E.K.; Fogarty, Andrew; McKeever, Tricia M.; Nickle, David C.; Boss�, Yohan; van den Berge, Maarten; Faiz, Alen; Brouwer, Sharon; Vonk, Judith M.; de Vos, Paul; Brandsma, Corry Anke; Vermeulen, Corneel; Singapuri, Amisha; Heaney, Liam G.; Mansur, Adel H.; Chaudhuri, Rekha; Thomson, Neil C.; Holloway, John W.; Lockett, Gabrielle A.; Howarth, Peter H.; Niven, Robert; Simpson, Angela; Blakey, John D.; Tobin, Martin D.; Postma, Dirkje S.; Hall, Ian P.; Wain, Louise V.; Nawijn, Martijn C.; Brightling, Christopher E.; Koppelman, Gerard H.; Sayers, Ian

doi:10.1172/jci.insight.132446

All Outputs (4)

CHAARM: A model to predict uncertainties in indoor pollutant concentrations, ventilation and infiltration rates, and associated energy demand in Chilean houses (2020)
Journal Article
Molina, C., Jones, B., Hall, I. P., & Sherman, M. H. (2021). CHAARM: A model to predict uncertainties in indoor pollutant concentrations, ventilation and infiltration rates, and associated energy demand in Chilean houses. Energy and Buildings, 230, Article 110539. https://doi.org/10.1016/j.enbuild.2020.110539

Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study (2020)
Journal Article
Safavi, S., Arthofer, C., Cooper, A., Harkin, J. W., Prayle, A. P., Sovani, M. P., …Hall, I. P. (2020). Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study. European Journal of Radiology, 130, Article 109196. https://doi.org/10.1016/j.ejrad.2020.109196

Purpose The diaphragm is the most important muscle of respiration. Disorders of the diaphragm can have a deleterious impact on respiratory function. We aimed to evaluate the use of an open-configuration upright low-field MRI system to assess diaphra... Read More about Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study.

Phenotypic and functional translation of IL33 genetics in asthma (2020)
Journal Article
Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., …Nawijn, M. C. (2021). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology, 147(1), 144-157. https://doi.org/10.1016/j.jaci.2020.04.051

© 2020 Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevate... Read More about Phenotypic and functional translation of IL33 genetics in asthma.

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020)
Journal Article
Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., …Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8), Article 132446. https://doi.org/10.1172/jci.insight.132446

The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def... Read More about Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.