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Scoping the international impact from four independent national dermatology trials (2020)
Journal Article
Williams, H. C., Rogers, N. K., Chalmers, J. R., & Thomas, K. S. (2021). Scoping the international impact from four independent national dermatology trials. Clinical and Experimental Dermatology, 46(4), 657-662. https://doi.org/10.1111/ced.14506

Background: Research impact describes whether and how research results in wider benefits to society beyond academic publication. Little is known about translation of clinical trial research into dermatological practice. Aim: We scoped international i... Read More about Scoping the international impact from four independent national dermatology trials.

Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-light vitiligo three-arm RCT (2020)
Journal Article
Batchelor, J. M., Thomas, K. S., Akram, P., Azad, J., Bewley, A., Chalmers, J. R., …Montgomery, A. A. (2020). Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-light vitiligo three-arm RCT. Health Technology Assessment, 24(64), 1-164. https://doi.org/10.3310/hta24640

Background: Systematic reviews suggest that narrowband ultraviolet B light combined with treatments such as topical corticosteroids may be more effective than monotherapy for vitiligo. Objective: To explore the clinical effectiveness and cost-effecti... Read More about Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-light vitiligo three-arm RCT.

A self-report questionnaire to detect hand dermatitis in nurses (2020)
Journal Article
Parsons, V., Williams, H. C., English, J., Llewellyn, J., Ntani, G., & Madan, I. (2020). A self-report questionnaire to detect hand dermatitis in nurses. Occupational Medicine, 70(9), 645-648. https://doi.org/10.1093/occmed/kqaa188

Background: Hand dermatitis is highly prevalent among nurses due to their frequent exposure to wet work. Providing cost-effective dermatological health surveillance for this occupational group presents a challenge to health service providers. Aims: T... Read More about A self-report questionnaire to detect hand dermatitis in nurses.

Interventions for basal cell carcinoma of the skin (2020)
Journal Article
Thomson, J., Hogan, S., Leonardi-Bee, J., Williams, H. C., & Bath-Hextall, F. J. (2020). Interventions for basal cell carcinoma of the skin. Cochrane Library, 2020, Article CD003412. https://doi.org/10.1002/14651858.CD003412.pub3

Background: Basal cell carcinoma (BCC) is the commonest cancer affecting white-skinned individuals, and worldwide incidence is increasing. Although rarely fatal, BCC is associated with significant morbidity and costs. First-line treatment is usually... Read More about Interventions for basal cell carcinoma of the skin.

An economic evaluation of the randomized controlled trial of topical corticosteroid and home-based narrowband ultraviolet B for active and limited vitiligo (the HI-Light Vitiligo Trial)* (2020)
Journal Article
Sach, T., Thomas, K., Batchelor, J., Akram, P., Chalmers, J., Haines, R., …The UK Dermatology Clinical Trials Network’s HI‐LIGHT Vitiligo Trial Team. (2021). An economic evaluation of the randomized controlled trial of topical corticosteroid and home-based narrowband ultraviolet B for active and limited vitiligo (the HI-Light Vitiligo Trial)*. British Journal of Dermatology, 184(5), 840-848. https://doi.org/10.1111/bjd.19554

Background: Economic evidence for vitiligo treatments is absent. Objectives: To determine the cost-effectiveness of (i) handheld narrowband ultraviolet B (NB-UVB) and (ii) a combination of topical corticosteroid (TCS) and NB-UVB compared with TCS alo... Read More about An economic evaluation of the randomized controlled trial of topical corticosteroid and home-based narrowband ultraviolet B for active and limited vitiligo (the HI-Light Vitiligo Trial)*.

Randomised controlled trial of topical corticosteroid and home?based narrowband UVB for active and limited vitiligo: results of the HI?Light Vitiligo trial (2020)
Journal Article
Thomas, K., Batchelor, J. M., Akram, P., Chalmers, J. R., Haines, R., Meakin, G. D., …Montgomery, A. A. (2021). Randomised controlled trial of topical corticosteroid and home‐based narrowband UVB for active and limited vitiligo: results of the HI‐Light Vitiligo trial. British Journal of Dermatology, 184(5), 828-839. https://doi.org/10.1111/bjd.19592

Background Evidence for the effectiveness of vitiligo treatments is limited. Objectives To determine effectiveness of (a) hand‐held narrowband‐UVB (NB‐UVB) and (b) combination of potent topical corticosteroid (TCS) and NB‐UVB compared to TCS, fo... Read More about Randomised controlled trial of topical corticosteroid and home?based narrowband UVB for active and limited vitiligo: results of the HI?Light Vitiligo trial.

Personalised prediction of daily eczema severity scores using a mechanistic machine learning model (2020)
Journal Article
Hurault, G., Domínguez‐Hüttinger, E., Langan, S. M., Williams, H. C., & Tanaka, R. J. (2020). Personalised prediction of daily eczema severity scores using a mechanistic machine learning model. Clinical and Experimental Allergy, 50(11), 1258-1266. https://doi.org/10.1111/cea.13717

Background Atopic dermatitis (AD) is a chronic inflammatory skin disease with periods of flares and remission. Designing personalised treatment strategies for AD is challenging, given the apparent unpredictability and large variation in AD symptom... Read More about Personalised prediction of daily eczema severity scores using a mechanistic machine learning model.

Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial (2020)
Journal Article
Bradshaw, L., Montgomery, A. A., Williams, H. C., Chalmers, J., & Haines, R. (2020). Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial. Trials, 21, https://doi.org/10.1186/s13063-020-04373-4

Background Failure to collect outcome data in randomised trials can result in bias and loss of statistical power. Further evaluations of strategies to increase retention are required. We assessed the effectiveness of two strategies for retention in... Read More about Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial.

Prevention of Atopic Dermatitis (2020)
Journal Article
Williams, H. C., & Chalmers, J. (2020). Prevention of Atopic Dermatitis. Acta Dermato-Venereologica, 100, 380-388. https://doi.org/10.2340/00015555-3516

Despite advances in atopic dermatitis (AD) treatments, research into AD prevention has been slow. Systematic reviews of prevention strategies promoting exclusive and prolonged breastfeeding, or interventions that reduce ingested or airborne allergens... Read More about Prevention of Atopic Dermatitis.

Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem (2020)
Journal Article
Craig, J. C., Ravaud, P., Créquit, P., Williams, H. C., Meerpohl, J., & Boutron, I. (2020). Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem. Journal of Clinical Epidemiology, 123, 153-161. https://doi.org/10.1016/j.jclinepi.2020.01.027

The “one-off” approach of systematic reviews is no longer sustainable; we need to move toward producing “living” evidence syntheses (i.e., comprehensive, based on rigorous methods, and up-to-date). This implies rethinking the evidence synthesis ecosy... Read More about Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem.

Future of evidence ecosystem series: 2. Current opportunities and need for better tools and methods (2020)
Journal Article
Créquit, P., Boutron, I., Meerpohl, J., Williams, H., Craig, J., & Ravaud, P. (2020). Future of evidence ecosystem series: 2. Current opportunities and need for better tools and methods. Journal of Clinical Epidemiology, 123, 143-152. https://doi.org/10.1016/j.jclinepi.2020.01.023

To become user-driven and more useful for decision-making, the current evidence synthesis ecosystem requires significant changes (Paper 1.Future of evidence ecosystem series). Reviewers have access to new sources of data (clinical trial registries, p... Read More about Future of evidence ecosystem series: 2. Current opportunities and need for better tools and methods.

Future of evidence ecosystem series: 1. Introduction — Evidence synthesis ecosystem needs dramatic change (2020)
Journal Article
Craig, J. C., Boutron, I., Créquit, P., Williams, H., Meerpohl, J., Craig, J. C., & Ravaud, P. (2020). Future of evidence ecosystem series: 1. Introduction — Evidence synthesis ecosystem needs dramatic change. Journal of Clinical Epidemiology, 123, 135-142. https://doi.org/10.1016/j.jclinepi.2020.01.024

To make healthcare decisions, patients, clinicians, clinical practice guideline developers, researchers, policy-makers and health system managers need a comprehensive, critical, accessible, actionable and up-to-date synthesis of all available evidenc... Read More about Future of evidence ecosystem series: 1. Introduction — Evidence synthesis ecosystem needs dramatic change.

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial (2020)
Journal Article
Chalmers, J. R., Haines, R. H., Bradshaw, L. E., Montgomery, A. A., Thomas, K. S., Brown, S. J., …Williams, H. C. (2020). Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. Lancet, 395(10228), 962-972. https://doi.org/10.1016/S0140-6736%2819%2932984-8

Background Skin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children. Methods We did a multicentre, pragmatic, parallel-group, randomised contr... Read More about Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial.

An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge (2020)
Journal Article
Kelleher, M. M., Montgomery, A. A., Jay, N., Perkin, M. R., Haines, R. H., Batt, R., …Boyle, R. J. (2020). An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge. Clinical and Experimental Allergy, 50(3), 334-342. https://doi.org/10.1111/cea.13577

© 2020 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd. Background: Food allergy diagnosis in clinical studies can be challenging. Oral food challenges (OFC) are time-consuming, carry some risk and may, therefore,... Read More about An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge.

Algorithm based smartphone apps to assess risk of skin cancer in adults: systematic review of diagnostic accuracy studies (2020)
Journal Article
Dinnes, J., Freeman, K., Chuchu, N., Takwoingi, Y., Bayliss, S. E., Matin, R. N., …Deeks, J. J. (2020). Algorithm based smartphone apps to assess risk of skin cancer in adults: systematic review of diagnostic accuracy studies. BMJ, 368, Article m127. https://doi.org/10.1136/bmj.m127

© Published by the BMJ Publishing Group Limited. Objective To examine the validity and findings of studies that examine the accuracy of algorithm based smartphone applications ("apps") to assess risk of skin cancer in suspicious skin lesions. Design... Read More about Algorithm based smartphone apps to assess risk of skin cancer in adults: systematic review of diagnostic accuracy studies.

A behaviour change package to prevent hand dermatitis in nurse working in the National Health Service: results of a cluster randomised controlled trial (2020)
Journal Article
Madan, I., Parsons, V., Ntani, G., Coggon, D., Wright, A., English, J., …Williams, H. C. (2020). A behaviour change package to prevent hand dermatitis in nurse working in the National Health Service: results of a cluster randomised controlled trial. British Journal of Dermatology, 183(3), 462-470. https://doi.org/10.1111/bjd.18862

Background Occupational hand dermatitis poses a serious risk for nurses. Objectives To evaluate the clinical and cost?effectiveness of a complex intervention in reducing the prevalence of hand dermatitis in nurses Trial design Cluster random... Read More about A behaviour change package to prevent hand dermatitis in nurse working in the National Health Service: results of a cluster randomised controlled trial.

Measuring atopic eczema symptoms in clinical practice: The first consensus statement from the Harmonising Outcome Measures for Eczema in clinical practice initiative (2020)
Journal Article
Leshem, Y. A., Chalmers, J. R., Apfelbacher, C., Furue, M., Gerbens, L. A., Prinsen, C. A., …Simpson, E. L. (2020). Measuring atopic eczema symptoms in clinical practice: The first consensus statement from the Harmonising Outcome Measures for Eczema in clinical practice initiative. Journal of The American Academy of Dermatology, 82(5), 1181-1186. https://doi.org/10.1016/j.jaad.2019.12.055

Background: Measuring patient-centered outcomes in clinical practice is valuable for monitoring patients and advancing real-world research. A new initiative from the Harmonising Outcome Measures for Eczema (HOME) group aims to recommend what might be... Read More about Measuring atopic eczema symptoms in clinical practice: The first consensus statement from the Harmonising Outcome Measures for Eczema in clinical practice initiative.