Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors
(2019)
Journal Article
Shuai, W., Li, W., Yin, Y., Yang, L., Xu, F., Xu, S., …Xu, J. (2019). Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors. Future Medicinal Chemistry, 11(20), 2687-2699. https://doi.org/10.4155/fmc-2019-0125
A series of novel isothio- and isoselenochromanone derivatives bearing N-benzyl pyridinium moiety were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. Results: Most of the target compounds exhibited potent anti-AChE act... Read More about Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors.