The Hepatitis C Awareness Through to Treatment (HepCATT) study: improving the cascade of care for hepatitis C virus-infected people who inject drugs in England

Harrison, Graham I.; Murray, Karen; Gore, Roxanne; Lee, Penelope; Sreedharan, Aravamuthan; Richardson, Paul; Hughes, Amanda J.; Wiselka, Martin; Gelson, Will; Unitt, Esther; Ratcliff, Karen; Orton, Annette; Trinder, Kerry; Simpson, Charlotte; Ryder, Stephen D.; Oelbaum, Sandra; Foster, Graham R.; Archie, Christian; Smith, Stuart; Thomson, Brian J.; Reynolds, Rosy; Harris, Magdalena; Hickman, Matthew; Irving, William L.

doi:10.1111/add.14569

All Outputs (7)

Interferon lambda 4 impacts the genetic diversity of hepatitis C virus (2019)
Journal Article
Ansari, M. A., Aranday-Cortes, E., Lc, C., Da Silva Filipe, A., Hin, L. S., Bamford, C. G., …Pedergnana, V. (2019). Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 2019(8), 1-23. https://doi.org/10.7554/eLife.42463

© Ansari et al. Hepatitis C virus (HCV) is a highly variable pathogen that frequently establishes chronic infection. This genetic variability is affected by the adaptive immune response but the contribution of other host factors is unclear. Here, we... Read More about Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.

Efficacy of direct‐acting antivirals: UK real‐world data from a well‐characterised predominantly cirrhotic HCV cohort (2019)
Journal Article
Macken, L., Gelson, W., Priest, M., Abouda, G., Barclay, S., Fraser, A., …Verma, S. (2019). Efficacy of direct‐acting antivirals: UK real‐world data from a well‐characterised predominantly cirrhotic HCV cohort. Journal of Medical Virology, 91(11), 1979-1988. https://doi.org/10.1002/jmv.25552

Direct-acting antivirals (DAAs) have revolutionised the management of chronic hepatitis C virus (HCV) infection. We describe UK real-world DAA experience. Individuals commencing HCV treatment containing a DAA regimen (Mar 2014-Nov 2016), participatin... Read More about Efficacy of direct‐acting antivirals: UK real‐world data from a well‐characterised predominantly cirrhotic HCV cohort.

The association between hepatocellular carcinoma and direct acting anti-vrial treatment in patients with decompensated cirrhosis (2019)
Journal Article
Jibran Mecci, A., Kemos, P., Leen, C., Lawson, A., Richardson, P., Khakoo, S. I., …Irving, W. L. (2019). The association between hepatocellular carcinoma and direct acting anti-vrial treatment in patients with decompensated cirrhosis. Alimentary Pharmacology and Therapeutics, 50(2), 204-214. https://doi.org/10.1111/apt.15296

Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir (2019)
Journal Article
Wing, P. A., Jones, M., Cheung, M., DaSilva, S., Bamford, C., Jason Lee, W., …Foster, G. R. (2019). Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir. Gastroenterology, 157(3), 692-704.e9. https://doi.org/10.1053/j.gastro.2019.05.007

Background & Aims: Sofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections and resistance-associated substitutions in the polymerase are rare. However, HCV genotyp... Read More about Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir.

Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses (2019)
Journal Article
Irving, W. L., Jalal, P. J., Urbanowicz, R. A., Horncastle, E., Pathak, M., Goddard, C., …Tarr, A. W. (2019). Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses. Journal of Medical Microbiology, 68(4), 642-648. https://doi.org/10.1099/jmm.0.000935

The liver-expressed pattern recognition receptors (PRRs) mannose binding lectin (MBL), ficolin-2 and ficolin-3 contribute to the innate immune response by activating complement. Binding of soluble ficolin-2 to viral pathogens can directly neutralize... Read More about Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses.

Testing for hepatitis C virus infection in UK prisons: what actually happens? (2019)
Journal Article
Jack, K., Thomson, B. J., & Irving, W. L. (2019). Testing for hepatitis C virus infection in UK prisons: what actually happens?. Journal of Viral Hepatitis, 26(6), 644-654. https://doi.org/10.1111/jvh.13071

Prisons are a key demographic in the drive to eradicate hepatitis C virus (HCV) as a major public health threat. We have assessed the impact of the recently introduced national opt-out policy on the current status of HCV testing in 14 prisons in the... Read More about Testing for hepatitis C virus infection in UK prisons: what actually happens?.

The Hepatitis C Awareness Through to Treatment (HepCATT) study: improving the cascade of care for hepatitis C virus-infected people who inject drugs in England (2019)
Journal Article
Harrison, G. I., Murray, K., Gore, R., Lee, P., Sreedharan, A., Richardson, P., …Irving, W. L. (2019). The Hepatitis C Awareness Through to Treatment (HepCATT) study: improving the cascade of care for hepatitis C virus-infected people who inject drugs in England. Addiction, 114(6), 1113-1122. https://doi.org/10.1111/add.14569

Background and Aims: Previous studies have shown low rates of diagnosis and treatment of hepatitis C virus (HCV) infection in people who inject drugs (PWID). Our aims were to test the effect of a complex intervention (“HepCATT”) in drug and alcohol c... Read More about The Hepatitis C Awareness Through to Treatment (HepCATT) study: improving the cascade of care for hepatitis C virus-infected people who inject drugs in England.