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All Outputs (3)

Osteocalcin does not influence acute or chronic inflammation in human vascular cells (2019)
Journal Article
Millar, S. A., Zala, I., Anderson, S. I., & O'Sullivan, S. E. (2020). Osteocalcin does not influence acute or chronic inflammation in human vascular cells. Journal of Cellular Physiology, 235(4), 3414-3424. https://doi.org/10.1002/jcp.29231

Some human observational studies have suggested an anti-inflammatory role of osteocalcin (OCN). An inflammatory protocol using IFN-γ and TNF-α (10 ng/mL) was employed to examine the acute (24 hr) and chronic (144 hr) effects of uncarboxylated OCN (uc... Read More about Osteocalcin does not influence acute or chronic inflammation in human vascular cells.

Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2 (2019)
Journal Article
Millar, S. A., Anderson, S. I., & O'Sullivan, S. E. (2019). Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2. PeerJ, 7, https://doi.org/10.7717/peerj.7139

Bone-derived factors that demonstrate extra-skeletal functions, also termed osteokines, are fast becoming a highly interesting and focused area of cross-disciplinary endocrine research. Osteocalcin (OCN), fibroblast growth factor-23 (FGF23) and lipoc... Read More about Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2.

Human vascular cell responses to the circulating bone hormone osteocalcin (2019)
Journal Article
Millar, S. A., Anderson, S. I., & O'sullivan, S. E. (2019). Human vascular cell responses to the circulating bone hormone osteocalcin. Journal of Cellular Physiology, 234(11), 21039-21048. https://doi.org/10.1002/jcp.28707

The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothel... Read More about Human vascular cell responses to the circulating bone hormone osteocalcin.