Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial

Bath, Philip M; Scutt, Polly; Anderson, Craig S; Appleton, Jason P; Berge, Evind; Cala, Lesley; Dixon, Mark; England, Timothy M; Godolphin, Peter J; Havard, Diane; Haywood, Lee; Hepburn, Trish; Krishnan, Kailash; Mair, Grant; Montgomery, Alan A; Muir, Keith; Phillips, Stephen J; Pocock, Stuart; Potter, John; Price, Chris; Randall, Marc; Robinson, Thompson G; Roffe, Christine; Rothwell, Peter M; Sandset, Else C; Sanossian, Nerses; Saver, Jeffrey L; Shone, Angela; Niroshan Siriwardena, A; Wardlaw, Joanna M; Woodhouse, Lisa J; Venables, Graham; Sprigg, Nikola; Amarenco, Pierre; Muir, Keith; Amoils, Shannon; Jarvis, Malcolm; Rothwell, Peter M; Sandercock, Peter; Asplund, Kjell; Baigent, Colin; Ankolekar, Sandeep; Howard, Harriet; Lysons, Christopher; Walker, Gemma; Gregory, Hayley; Kirby, James; Smithson, Jennifer; Keeling, Joanne; Frowd, Nadia; Gray, Robert; Dooley, Richard; Clarke, Wim; Robinson, Patricia; Kang Law, Zhe; Hodgson, Sheila; Millington, Adam; Sakka, Eleni; Buchanan, David; Palmer, Jeb; Shaw, D; Cobb, H; Johnson, R; Payne, T; Spaight, R; Spaight, A; Sajid, M A; Whileman, A; Hall, E; Cripps, H; Toms, J; Gascoyne, R; Wright, S; Cooper, M; Palfreman, A; Rajapakse, A; Wynter, I; Musarrat, K; Mistri, A; Patel, C; Stephens, C; Khan, S; Patras, S; Soliman, M; Elmarimi, A; Hewitt, C; Watson, E; Wahishi, I; Hindle, J; Perkin, L; Wills, M; Arif, S; Leach, S; Butler, S; O'Kane, D; Smith, C; O'Callaghan, J; Sunman, W; Buck, A; Jackson, B; Richardson, C; Wilkes, G; Clarke, J; Ryan, L; Matias, O; Mangion, D; Hardwick, A; Constantin, C; Thomas, I; Netherton, K; Markova, S; Hedstrom, A; Rushton, B; Hyde, C; Scott, J; Blair, M; Maddula, M; Donnelly, R; Keane, S; Johnson, S; McKenzie, H; Banerjee, A; Hutchinson, D; Goodhand, H; Hill, J; Mellows, K; Cheeseman, M; McTaggart, V; Foster, T; Prothero, L; Saksena, P; O'Kelly, A; Wyllie, H; Hacon, C; Nutt, H; North, J; Goffin, K; Potter, J; Wiltshire, A; Ravenhill, G; Metcalf, K; Ford, L; Langley, M; Davison, W; Subramonian, S; Magezi, F; Obi, I; Temple, N; Butterworth-Cowin, N; Oqwusu-Agyei, P; Azim, A F M; Nicolson, A; Imam, J; White, J; Wood, L; Fothergill, R; Thompson, N; Lazarus, J; Werts, H; Sztriha, L; Ho, C; McKenzie, E; Owoyele, E; Lim, J; Aeron-Thomas, J; Dockey, M; Sylvester, N; Rao, P; Bloom, B M; Erumere, E; Norman, G; Skene, I; Cuenoud, L; Howaniec, L; Boulton, O; Daboo, P; Michael, R; Al-Saadi, S; Harrison, T; Syed, H; Argandona, L; Amiani, S; Perry, R; Ashton, A; Banaras, A; Hogan, C; Watchurst, C; Elliott, E; Francia, N; Oji, N; Erande, R; Obarey, S; Feerick, S; Tshuma, S; England, E; Pocock, H; Poole, K; Manchanda, S; Burn, I; Dayal, S; McNee, K; Robinson, M; Hancock, R; South, A; Holmes, C; Steele, A; Guthrie, L B; Oborn, M; Mohd Nor, A; Hyams, B; Eglinton, C; Waugh, D; Cann, E; Wilmhurst, N; Piesley, S; Shave, S; Dutta, D; Obeid, M; Ward, D; Turfrey, J; Glass, J; Bowstead, K; Hill, L; Brown, P; Beames, S; O'Connell, S; Hughes, V; Whiting, R; Gagg, J; Hussain, M; Harvey, M; Karunatilake, D; Pusuluri, B; Witcher, A; Pawley, C; Allen, J; Foot, J; Rowe, J; Lane, C; Ragab, S; Wadams, B; Dube, J; Jupp, B; Ljubez, A; Bagnall, C; Hann, G; Tucker, L; Kelton, M; Orr, S; Harrington, F; James, A; Lydon, A; Courtauld, G; Bond, K; Lucas, L; Nisbett, T; Kubie, J; Bowring, A; Jennings, G; Thorpe, K; Mason, N; Keenan, S; Gbadomishi, L; Howcroft, D; Newton, H; Choulerton, J; Avis, J; Shaw, L; Paterson, P; Kaye, P; Hierons, S; Lucas, S; Clatworthy, P; Faulkner, B; Rannigan, L; Worner, R; Bhaskaran, B; Saulat, A; Bearne, H; Garfield-Smith, J; Horan, K; Fitzell, P; Szabo, S; Haley, M; Simmons, D; Cotterill, D; Saunders, G; Dymond, H; Beech, S; Rashed, K; Tanate, A; Buckley, C; Wood, D; Matthews, L; Board, S; Pitt-Kirby, T; Rees, N; Convery, C; Jones, P; Bryant, C; Tench, H; Dixon, M; Loosley, R; Coetzee, S; Jones, S; Sims, T; Krishnan, M; Davies, C; Quinn, L; Connor, L; Wani, M; Storton, S; Treadwell, S; Anjum, T; Somashekar, C; Chandler, A; Triscott, C; Bevan, L; Sander, M; Buckle, S; Sayed, W; Andrews, K; Hughes, L; Hughes, R; Ward, M; Pretty, A; Rosser, A; Davidson, B; Price, G; Gunson, I; Lumley-Holmes, J; Miller, J; Larden, M; Jhamat, M; Horwood, P; Boldy, R; Jenkins, C; Price, F; Harrison, M; Martin, T; Ahmad, N; Willberry, A; Stevens, A; Fotherby, K; Barry, A; Remegoso, A; Alipio, F; Maquire, H; Hiden, J; Finney, K; Varquez, R; Ispoglou, S; Hayes, A; Gull, D; Evans, R; Epstein, E; Hurdowar, S; Crossley, J; Miles, J; Hird, K; Pilbery, R; Patterson, C; Ramadan, H; Stewart, K; Quinn, O; Bellfield, R; Macquire, S; Gaba, W; Nair, A; Wilson, A; Hawksworth, C; Alam, I; Greig, J; Robinson, M; Gomes, P; Rana, P; Ahmed, Z; Anderston, P; Neal, A; Walstow, D; Fong, R; Brotheridge, S; Bwalya, A; Gillespie, A; Midgley, C; Hare, C; Lyon, H; Stephenson, L; Broome, M; Worton, R; Jackson, S; Rayessa, R; Abdul-Hamid, A; Naylor, C; Clarkson, E; Hassan, A; Waugh, D; Veraque, E; Finch, L; Makawa, L; Carpenter, M; Datta, P; Needle, A; Jackson, L; Brooke, H J; Ball, J; Lowry, T; Punnoose, S; Walker, R; Murray, V; Ali, A; Kamara, C; Doyle, C; Richards, E; Howe, J; Dakin, K; Harkness, K; Lindert, R; Wanklyn, P; Willcoxson, P; Clark-Brown, P; Mir, R

doi:10.1016/S0140-6736(19)30194-1

All Outputs (2)

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage (2019)
Journal Article
Bath, P. M., Woodhouse, L. J., Krishnan, K., Appleton, J. P., Anderson, C. S., Berge, E., …Sprigg, N. (2019). Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage. Stroke, 50(11), 3064-3071. https://doi.org/10.1161/STROKEAHA.119.026389

Background and Purpose— Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset. Methods— We undertook a multicentre, paramedic-delivered, ambulance-based, prospective ran... Read More about Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage.

Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial (2019)
Journal Article
Bath, P. M., Scutt, P., Anderson, C. S., Appleton, J. P., Berge, E., Cala, L., …Mir, R. (2019). Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial. Lancet, 393(10175), 1009-1020. https://doi.org/10.1016/S0140-6736%2819%2930194-1

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure... Read More about Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial.