All Outputs (7)

Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis (2019)
Journal Article
Lansbury, L. E., Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., & Shen Lim, W. (2020). Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis. Critical Care Medicine, 48(2), e98-e106. https://doi.org/10.1097/ccm.0000000000004093

Objective: Corticosteroids may be beneficial in sepsis but uncertainty remains over their effects in severe influenza. This systematic review updates the current evidence regarding corticosteroids in the treatment of influenza and examines the effect... Read More about Corticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis.

A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic (2019)
Journal Article
Venkatesan, S., Nguyen-Van-Tam, J., & Siebers, P. (2019). A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic. PLoS ONE, 14(10), https://doi.org/10.1371/journal.pone.0223946

© 2019 Venkatesan et al. The importance of accounting for social and behavioural processes when studying public health emergencies has been well-recognised. For infectious disease outbreaks in particular, several methods of incorporating individual b... Read More about A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic.

Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS) (2019)
Journal Article
Roosenhoff, R., Reed, V., Kenwright, A., Schutten, M., Boucher, C. A., Monto, A., …Fraaij, P. L. A. (2020). Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS). Clinical Infectious Diseases, 71(5), 1186–1194. https://doi.org/10.1093/cid/ciz939

Background We studied the effect of age, baseline viral load, vaccination status, antiviral therapy, and emergence of drug resistance on viral shedding in children infected with influenza A or B virus. Methods Samples from children (aged ≤13... Read More about Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS).

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection (2019)
Journal Article
Venkatesan, S., Myles, P. R., Bolton, K. J., Muthuri, S. G., Al Khuwaitir, T., Anovadiya, A. P., …Nguyen-Van-Tam, J. S. (2020). Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection. Journal of Infectious Diseases, 221(3), 356–366. https://doi.org/10.1093/infdis/jiz152

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment o... Read More about Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection.

A Rapid Evidence Appraisal of influenza vaccination in health workers: an important policy in an area of imperfect evidence (2019)
Journal Article
Jenkin, D. C., Mahgoub, H., Morales, K. F., Lambach, P., & Nguyen-Van-Tam, J. S. (2019). A Rapid Evidence Appraisal of influenza vaccination in health workers: an important policy in an area of imperfect evidence. Vaccine, 2, https://doi.org/10.1016/j.jvacx.2019.100036

Introduction The World Health Organization recommends vaccination of health workers (HWs) against influenza, but low uptake is intransigent. We conducted a Rapid Evidence Appraisal on: the risk of influenza in HWs, transmission risk from HWs to... Read More about A Rapid Evidence Appraisal of influenza vaccination in health workers: an important policy in an area of imperfect evidence.

Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M. J., Myles, P., Mallen, C. D., Zhang, W., Doherty, M., …Abhishek, A. (2019). Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 78(8), 1122-1126. https://doi.org/10.1136/annrheumdis-2019-215086

Objectives To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis, and unexplained fever in people w... Read More about Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink.

Corticosteroids as adjunctive therapy in the treatment of influenza (2019)
Journal Article
Lansbury, L., Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., & Lim, W. S. (2019). Corticosteroids as adjunctive therapy in the treatment of influenza. Cochrane Database of Systematic Reviews, 2019(2), Article CD010406. https://doi.org/10.1002/14651858.CD010406.pub3

Background Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti‐inflammatory and immunomodulatory properti... Read More about Corticosteroids as adjunctive therapy in the treatment of influenza.