All Outputs (12)

Delay in Source Control in Perforated Peptic Ulcer Leads to 6% Increased Risk of Death Per Hour: A Nationwide Cohort Study (2019)
Journal Article
Boyd-Carson, H., Doleman, B., Cromwell, D., Lockwood, S., Williams, J. P., Tierney, G. M., …for The National Emergency Laparotomy Audit Collaboration. (2019). Delay in Source Control in Perforated Peptic Ulcer Leads to 6% Increased Risk of Death Per Hour: A Nationwide Cohort Study. World Journal of Surgery, 44, 869–875. https://doi.org/10.1007/s00268-019-05254-x

© 2019, Société Internationale de Chirurgie. Background: Delay to theatre for patients with intra-abdominal sepsis is cited as a particular risk factor for death. Our aim was to evaluate the potential relationship between hourly delay from admission... Read More about Delay in Source Control in Perforated Peptic Ulcer Leads to 6% Increased Risk of Death Per Hour: A Nationwide Cohort Study.

A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection (2019)
Journal Article
Hossain, T., Phillips, B. E., Doleman, B., Lund, J. N., & Williams, J. P. (2020). A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection. Clinical Nutrition, 39(7), 2055-2061. https://doi.org/10.1016/j.clnu.2019.09.009

Background Resection of colorectal cancer (CRC) initiates inflammation, mediated at least partly by NFĸB (nuclear factor kappa-light-chain-enhancer of activated B-cells), leading to muscle catabolism and reduced physical performance. Eicosapentaen... Read More about A double-blind randomized controlled trial of the effects of eicosapentaenoic acid supplementation on muscle inflammation and physical function in patients undergoing colorectal cancer resection.

Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients (2019)
Journal Article
Thomas, P. W., Blackwell, J. E. M., Herrod, P. J. J., Peacock, O., Singh, R., Williams, J. P., …Lund, J. N. (2019). Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients. Techniques in Coloproctology, 23(8), 761-767. https://doi.org/10.1007/s10151-019-02056-0

Background Current evidence suggests that pelvic floor reconstruction following extralevator abdominoperineal excision of rectum (ELAPER) may reduce the risk of perineal herniation of intra-abdominal contents. Options for reconstruction include mesh... Read More about Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients.

Why most published meta-analysis findings are false (2019)
Journal Article
Doleman, B., Williams, J. P., & Lund, J. (2019). Why most published meta-analysis findings are false. Techniques in Coloproctology, 23(9), 925-928. https://doi.org/10.1007/s10151-019-02020-y

Almost a decade after the controversial paper ‘why most published research findings are false’ was written [1], we re-visit this concern with regard to published meta-analyses. Although reading the title of this article may make some pause for though... Read More about Why most published meta-analysis findings are false.

Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients (2019)
Journal Article
Boereboom, C. L., Blackwell, J. E., Williams, J. P., Phillips, B. E., & Lund, J. N. (2019). Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients. Scandinavian Journal of Medicine and Science in Sports, 29(9), 1383-1391. https://doi.org/10.1111/sms.13460

Background: Preoperative cardiorespiratory fitness (CRF) in colorectal cancer patients has been shown to affect postoperative outcomes. The aim of this study was to test the feasibility of high-intensity interval training (HIT) for improving fitness... Read More about Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients.

Association between surgeon special interest and mortality after emergency laparotomy (2019)
Journal Article
Boyd‐Carson, H., Doleman, B., Herrod, P. J. J., Anderson, I. D., Williams, J. P., Lund, J. N., …on behalf of the NELA Collaboration. (2019). Association between surgeon special interest and mortality after emergency laparotomy. British Journal of Surgery, 106(7), 940-948. https://doi.org/10.1002/bjs.11146

© 2019 BJS Society Ltd Published by John Wiley & Sons Ltd Background: Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are... Read More about Association between surgeon special interest and mortality after emergency laparotomy.

The acute transcriptional response to resistance exercise: impact of age and contraction mode (2019)
Journal Article
Deane, C. S., Ames, R. M., Phillips, B. E., Weedon, M. N., Willis, C. R., Boereboom, C., …Etheridge, T. (2019). The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging, 11(7), 2111-2126. https://doi.org/10.18632/aging.101904

Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We... Read More about The acute transcriptional response to resistance exercise: impact of age and contraction mode.

The impact of pre‐operative intravenous iron on quality of life after colorectal cancer surgery: outcomes from the intravenous iron in colorectal cancer‐associated anaemia (IVICA) trial (2019)
Journal Article
Keeler, B. D., Dickson, E. A., Simpson, J. A., Ng, O., Padmanabhan, H., Brookes, M. J., …Moriarty, C. (2019). The impact of pre‐operative intravenous iron on quality of life after colorectal cancer surgery: outcomes from the intravenous iron in colorectal cancer‐associated anaemia (IVICA) trial. Anaesthesia, 74(6), 714-725. https://doi.org/10.1111/anae.14659

Anaemia is associated with a reduction in quality of life, and is common in patients with colorectal cancer . Werecently reported thefindings of the intravenous iron in colorectal cancer-associated anaemia (IVICA) trialcomparing haemoglobin levels an... Read More about The impact of pre‐operative intravenous iron on quality of life after colorectal cancer surgery: outcomes from the intravenous iron in colorectal cancer‐associated anaemia (IVICA) trial.

Surgical interventions for the treatment of sacrococcygeal pilonidal sinus disease in children: a systematic review and meta-analysis (2019)
Journal Article
Hardy, E. J. O., Herrod, P. J., Doleman, B., Phillips, H. G., Ranat, R., & Lund, J. N. (2019). Surgical interventions for the treatment of sacrococcygeal pilonidal sinus disease in children: a systematic review and meta-analysis. Journal of Pediatric Surgery, https://doi.org/10.1016/j.jpedsurg.2019.02.058

Background Pilonidal sinus disease (PNS) is not uncommon in children. Controversy remains over the best treatment and there is limited evidence. This systematic review and meta-analysis aims to establish which techniques have the best outcomes in... Read More about Surgical interventions for the treatment of sacrococcygeal pilonidal sinus disease in children: a systematic review and meta-analysis.

National prospective cohort study of the burden of acute small bowel obstruction (2019)
Journal Article
Lee, M. J., Sayers, A. E., Drake, T. M., Marriott, P. J., Anderson, I. D., Bach, S. P., …Lund, J. (2019). National prospective cohort study of the burden of acute small bowel obstruction. BJS Open, 3(3), 354-366. https://doi.org/10.1002/bjs5.50136

Background Small bowel obstruction is a common surgical emergency, and is associated with high levels of morbidity and mortality across the world. The literature provides little information on the conservatively managed group. The aim of this stud... Read More about National prospective cohort study of the burden of acute small bowel obstruction.

Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection (2019)
Journal Article
Herrod, P. J., Boyd-Carson, H., Doleman, B., Trotter, J., Schlichtemeier, S., Sathanapally, G., …Lund, J. N. (2019). Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection. Techniques in Coloproctology, 23(2), 129–134. https://doi.org/10.1007/s10151-019-1928-0

Purpose: Radiologically-defined sarcopenia has been shown to predict negative outcomes after cancer surgery, however radiological assessment of sarcopenia often requires additional software and standardisation against anthropomorphic data. Measuring... Read More about Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection.

Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo—A Randomized, Placebo-controlled, Double-blind Controlled Trial (2019)
Journal Article
Couch, D. G., Cook, H., Ortori, C., Barrett, D., Lund, J. N., & O’Sullivan, S. E. (2019). Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo—A Randomized, Placebo-controlled, Double-blind Controlled Trial. Inflammatory Bowel Diseases, 25(6), 1006-1018. https://doi.org/10.1093/ibd/izz017

Background and aims We aimed to examine, for the first time, the effect of cannabidiol (CBD) and palmitoylethanolamide (PEA) on the permeability of the human gastrointestinal tract in vitro, ex vivo, and in vivo. Methods Flux measurements of fluor... Read More about Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo—A Randomized, Placebo-controlled, Double-blind Controlled Trial.