Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles

Nicoletti, Paola; Aithal, Guruprasad P.; Chamberlain, Thomas C.; Coulthard, Sally; Alshabeeb, Mohammad; Grove, Jane I.; Andrade, Raul J.; Bjornsson, Einar; Dillon, John F.; Hallberg, Par; Lucena, M. Isabel; Maitland-van der Zee, Anke H.; Martin, Jennifer H.; Molokhia, Mariam; Pirmohamed, Munir; Wadelius, Mia; Shen, Yufeng; Nelson, Matthew R.; Daly, Ann K.

doi:10.1002/cpt.1375

All Outputs (3)

Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis (2019)
Journal Article
Astbury, S., Atallah, E., Vijay, A., Aithal, G., Grove, J., & Valdes, A. (2020). Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis. Gut Microbes, 11(3), 569-580. https://doi.org/10.1080/19490976.2019.1681861

There is increasing evidence for the role of gut microbial composition in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Non-alcoholic steatohepatitis (NASH) is the most serious form of NAFLD where inflammation causes liver damage tha... Read More about Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associated with biopsy-proven non-alcoholic steatohepatitis.

Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort (2019)
Journal Article
Chalmers, J., Ban, L., Leena, K., Edwards, K., Grove, J., Aithal, G., & Shenoy, K. (2019). Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort. BMJ Open, 9(5), https://doi.org/10.1136/bmjopen-2018-027244

Purpose The Trivandrum NAFLD cohort is a population-based study designed to examine the interaction between genetic and lifestyle factors and their association with increased risk of NAFLD within the Indian population. Participants Between 201... Read More about Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort.

Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles (2019)
Journal Article
Nicoletti, P., Aithal, G. P., Chamberlain, T. C., Coulthard, S., Alshabeeb, M., Grove, J. I., …Daly, A. K. (2019). Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles. Clinical Pharmacology and Therapeutics, 106(1), 245-253. https://doi.org/10.1002/cpt.1375

© 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics Some patients prescribed flucloxacillin (~0.01%) develop drug-induced liver injury (DILI). HLA-B*57:01 is an established gene... Read More about Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles.