All Outputs (4)

In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis (2019)
Journal Article
Rumney, R. M. H., Lanham, S. A., Kanczler, J. M., Kao, A. P., Thiagarajan, L., Dixon, J. E., …Oreffo, R. O. C. (2019). In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis. Scientific Reports, 9(1), Article 17745. https://doi.org/10.1038/s41598-019-53249-4

Deficient bone vasculature is a key component in pathological conditions ranging from developmental skeletal abnormalities to impaired bone repair. Vascularisation is dependent upon vascular endothelial growth factor (VEGF), which drives both angioge... Read More about In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis.

Molecular phenotyping of the surfaceome of migratory chondroprogenitors and mesenchymal stem cells using biotinylation, glycocapture and quantitative LC-MS/MS proteomic analysis (2019)
Journal Article
Matta, C., Boocock, D. J., Fellows, C. R., Miosge, N., Dixon, J. E., Liddell, S., …Mobasheri, A. (2019). Molecular phenotyping of the surfaceome of migratory chondroprogenitors and mesenchymal stem cells using biotinylation, glycocapture and quantitative LC-MS/MS proteomic analysis. Scientific Reports, 9, Article 9018. https://doi.org/10.1038/s41598-019-44957-y

© 2019, The Author(s). The complement of cell surface proteins, collectively referred to as the surfaceome, is a useful indicator of normal differentiation processes, and the development of pathologies such as osteoarthritis (OA). We employed biochem... Read More about Molecular phenotyping of the surfaceome of migratory chondroprogenitors and mesenchymal stem cells using biotinylation, glycocapture and quantitative LC-MS/MS proteomic analysis.

Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: From development to application in tissue engineering (2019)
Journal Article
Raftery, R. M., Walsh, D. P., Blokpoel Ferreras, L., Mencía Castaño, I., Chen, G., LeMoine, M., …O'Brien, F. J. (2019). Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: From development to application in tissue engineering. Biomaterials, 216, Article 119277. https://doi.org/10.1016/j.biomaterials.2019.119277

Gene therapy has recently come of age with seven viral vector-based therapies gaining regulatory approval in recent years. In tissue engineering, non-viral vectors are preferred over viral vectors, however, lower transfection efficiencies and difficu... Read More about Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: From development to application in tissue engineering.

Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model (2019)
Journal Article
Markides, H., Newell, K. J., Rudorf, H., Ferreras, L. B., Dixon, J. E., Morris, R. H., …El Haj, A. J. (2019). Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model. Stem Cell Research and Therapy, 10, 1-15. https://doi.org/10.1186/s13287-018-1123-7

Background Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research efforts. Pre-clinical studies... Read More about Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model.