Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

Mayer, Daniel; Damberger, Fred F.; Samarasimhareddy, Mamidi; Feldmueller, Miki; Vuckovic, Ziva; Flock, Tilman; Bauer, Brian; Mutt, Eshita; Zosel, Franziska; Allain, Fr�d�ric H. T.; Standfuss, J�rg; Schertler, Gebhard F. X.; Deupi, Xavier; Sommer, Martha E.; Hurevich, Mattan; Friedler, Assaf; Veprintsev, Dmitry B.

doi:10.1038/s41467-019-09204-y

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Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation (2019)
Journal Article
Mayer, D., Damberger, F. F., Samarasimhareddy, M., Feldmueller, M., Vuckovic, Z., Flock, T., …Veprintsev, D. B. (2019). Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation. Nature Communications, 10(1), 1-14. https://doi.org/10.1038/s41467-019-09204-y

Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution structural data of arrestins bound to phosphorylated receptor C-termi... Read More about Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation.