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Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome (2019)
Journal Article
Sander, K. N., Kim, D., Ortori, C. A., Warren, A. Y., Anyanwagu, U. C., Hay, D. P., …Barrett, D. A. (2019). Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome. Metabolomics, 15, 1-10. https://doi.org/10.1007/s11306-019-1600-8

Introduction Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies. Objectives As the pathophysiological processes of pre-eclampsia are still uncertain, the present case–control study explored unde... Read More about Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.

Comprehensive and quantitative profiling of B vitamins and related compounds in the mammalian liver (2019)
Journal Article
Xu, J., Clare, C. E., Brassington, A. H., Sinclair, K., & Barrett, D. (2020). Comprehensive and quantitative profiling of B vitamins and related compounds in the mammalian liver. Journal of Chromatography B, 1136, https://doi.org/10.1016/j.jchromb.2019.121884

A method for the simultaneous quantification of B vitamins and related amines in one-carbon (1C) metabolism would benefit the study of diet and genetic/epigenetic regulation of mammalian development and health. We present a validated method for the s... Read More about Comprehensive and quantitative profiling of B vitamins and related compounds in the mammalian liver.

Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis (2019)
Journal Article
Webb, K., Fogarty, A., Barrett, D. A., Nash, E. F., Whitehouse, J. L., Smyth, A. R., …Cámara, M. (2019). Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis. Journal of Medical Microbiology, 68(12), 1823-1828. https://doi.org/10.1099/jmm.0.001099

Introduction : Pseudomonas aeruginosa is an important respiratory pathogen in cystic fibrosis (CF), which is associated with an accelerated decline in lung function, frequent pulmonary exacerbations and increased mortality. P. aeruginosa produces in... Read More about Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin (2019)
Journal Article
Lee, J. B., Radhi, M., Cipolla, E., Gandhi, R. D., Sarmad, S., Zgair, A., …Gershkovich, P. (2019). A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin. Scientific Reports, 9, Article 15760. https://doi.org/10.1038/s41598-019-52254-x

Although adenosine and its analogues have been assessed in the past as potential drug candidates due to the important role of adenosine in physiology, only little is known about their absorption following oral administration. In this work, we have st... Read More about A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin.

Nuclear poly(A) tail size is regulated by Cnot1 during the serum response (2019)
Other
Singhania, R., Thorn, G. J., Williams, K., Gandhi, R. D., Daher, C., Barthet-Barateig, A., …de Moor, C. H. (2019). Nuclear poly(A) tail size is regulated by Cnot1 during the serum response

The poly(A) tail removal from mRNAs introduces a delay between mRNA synthesis and decay. We measured levels and poly(A) tail sizes of serum-induced mRNAs and used mathematical modelling to compare their deadenylation time with the delay in decay and... Read More about Nuclear poly(A) tail size is regulated by Cnot1 during the serum response.

Pharmacological profile of vascular activity of human stem villous arteries (2019)
Journal Article
Sander, K. N., Ali, T. Y., Warren, A. Y., Hay, D. P., Broughton Pipkin, F., Barrett, D. A., & Khan, R. N. (2019). Pharmacological profile of vascular activity of human stem villous arteries. Placenta, 88, 12-19. https://doi.org/10.1016/j.placenta.2019.09.009

© 2019 Introduction: The function of the placental vasculature differs considerably from other systemic vascular beds of the human body. A detailed understanding of the normal placental vascular physiology is the foundation to understand perturbed co... Read More about Pharmacological profile of vascular activity of human stem villous arteries.

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats (2019)
Journal Article
Pollard, A. K., Ingram, T. L., Ortori, C. A., Shephard, F., Brown, M., Liddell, S., …Chakrabarti, L. (2019). A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats. Aging, 11(6), 1664-1685. https://doi.org/10.18632/aging.101861

It is accepted that smaller mammals with higher metabolic rates have shorter lifespans. The very few species that do not follow these rules can give insights into interesting differences. The recorded maximum lifespans of bats are exceptional - over... Read More about A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats.

Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling (2019)
Journal Article
Starr, N. J., Hamid, K. A., Wibawa, J., Marlow, I., Bell, M., Pérez-García, L., …Scurr, D. J. (2019). Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling. International Journal of Pharmaceutics, 563, 21-29. https://doi.org/10.1016/j.ijpharm.2019.03.028

Vitamin C (ascorbic acid) is a naturally occurring, powerful anti-oxidant with the potential to deliver numerous benefits to the skin when applied topically. However, topical use of this compound is currently restricted by an instability in tradition... Read More about Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling.

Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo—A Randomized, Placebo-controlled, Double-blind Controlled Trial (2019)
Journal Article
Couch, D. G., Cook, H., Ortori, C., Barrett, D., Lund, J. N., & O’Sullivan, S. E. (2019). Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo—A Randomized, Placebo-controlled, Double-blind Controlled Trial. Inflammatory Bowel Diseases, 25(6), 1006-1018. https://doi.org/10.1093/ibd/izz017

Background and aims We aimed to examine, for the first time, the effect of cannabidiol (CBD) and palmitoylethanolamide (PEA) on the permeability of the human gastrointestinal tract in vitro, ex vivo, and in vivo. Methods Flux measurements of fluor... Read More about Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo—A Randomized, Placebo-controlled, Double-blind Controlled Trial.