Loss of ELK1 has differential effects on age-dependent organ fibrosis

Cairns, Jennifer T.; Habgood, Anthony; Edwards-Pritchard, Rochelle C.; Joseph, Chitra; John, Alison E.; Wilkinson, Chloe; Stewart, Iain D.; Leslie, Jack; Blaxall, Burns C.; Sustak, Katalin; Alberti, Siegfried; Nordheim, Alfred; Oakley, Fiona; Jenkins, Gisli; Tatler, Amanda L.

doi:10.1016/j.biocel.2019.105668

All Outputs (2)

Loss of ELK1 has differential effects on age-dependent organ fibrosis and integrin expression (2019)
Journal Article
Cairns, J. T., Habgood, A., Edwards-Pritchard, R. C., Wilkinson, C., Stewart, I. D., Leslie, J., …Tatler, A. L. (2020). Loss of ELK1 has differential effects on age-dependent organ fibrosis and integrin expression. International Journal of Biochemistry and Cell Biology, 120, Article 105668. https://doi.org/10.1016/j.biocel.2019.105668

ETS domain-containing protein-1 (ELK1) is a transcription factor important in regulating ?v?6 integrin expression. ?v?6 integrins activate the profibrotic cytokine Transforming Growth Factor ?1 (TGF?1) and are increased in the alveolar epithelium in... Read More about Loss of ELK1 has differential effects on age-dependent organ fibrosis and integrin expression.

Loss of ELK1 has differential effects on age-dependent organ fibrosis (2019)
Journal Article
Cairns, J. T., Habgood, A., Edwards-Pritchard, R. C., Joseph, C., John, A. E., Wilkinson, C., …Tatler, A. L. (2020). Loss of ELK1 has differential effects on age-dependent organ fibrosis. International Journal of Biochemistry and Cell Biology, 120, Article 105668. https://doi.org/10.1016/j.biocel.2019.105668

© 2019 The Author(s) ETS domain-containing protein-1 (ELK1) is a transcription factor important in regulating αvβ6 integrin expression. αvβ6 integrins activate the profibrotic cytokine Transforming Growth Factor β1 (TGFβ1) and are increased in the al... Read More about Loss of ELK1 has differential effects on age-dependent organ fibrosis.