Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer
(2019)
Journal Article
Morotti, M., Bridges, E., Valli, A., Choudhry, H., Sheldon, H., Wigfield, S., …Harris, A. L. (2019). Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer. Proceedings of the National Academy of Sciences, 116(25), 12452-12461. https://doi.org/10.1073/pnas.1818521116
Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α–positive (ERα+) breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here, we show that the glutamine t... Read More about Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.