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All Outputs (30)

Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus (2018)
Journal Article
Maan, S., Belaganahalli, M. N., Maan, N. S., Potgieter, A. C., & Mertens, P. P. C. (2019). Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus. Brazilian Journal of Microbiology, 50(1), 287-296. https://doi.org/10.1007/s42770-018-0034-1

© 2018, Sociedade Brasileira de Microbiologia. Equine encephalosis (EE) is an acute, arthropod-borne, noncontagious, febrile disease of equids. The clinical signs of EE are similar to milder forms of African horse sickness (AHS) and the two diseases... Read More about Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus.

Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii (2018)
Journal Article
Wang, M., Zhang, F., Elsheikha, H. M., Zhang, N., He, J., Luo, J., & Zhu, X. (2018). Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii. Parasites and Vectors, 11(1), Article 592. https://doi.org/10.1186/s13071-018-3179-8

Background: Although sexual reproduction of the parasite Toxoplasma gondii exclusively occurs in the cat intestine, knowledge about the alteration of gene expression in the intestine of cats infected with T. gondii is still limited. Here, we investig... Read More about Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii.

Using big data in cattle practice (2018)
Journal Article
Hudson, C., Kaler, J., & Down, P. (2018). Using big data in cattle practice. In Practice, 40(9), 396-410. https://doi.org/10.1136/inp.k4328

© 2018 BMJ Publishing Group Limited. The concept of big data, associated data sources and analytics is becoming increasingly talked about both in society as a whole and within the livestock industry. This article provides a clinician-focused review o... Read More about Using big data in cattle practice.

Survey-based pilot study into the chosen therapy and prophylaxis used by UK primary care veterinary surgeons against canine angiostrongylosis (2018)
Journal Article
Shuttleworth, A., Dunning, M., Wright, I., & Elsheikha, H. M. (2018). Survey-based pilot study into the chosen therapy and prophylaxis used by UK primary care veterinary surgeons against canine angiostrongylosis. Veterinary parasitology (Amsterdam), 14, 144-149. doi:10.1016/j.vprsr.2018.10.010

Canine Angiostrongylosis (CA), a gastropod-borne parasitic infection caused by the metastrongyloid nematode Angiostrongylus vasorum, is an important cause of significant morbidity to domestic dogs across the UK as well as in other European countries.... Read More about Survey-based pilot study into the chosen therapy and prophylaxis used by UK primary care veterinary surgeons against canine angiostrongylosis.

Implications of shunt morphology for the surgical management of extrahepatic portosystemic shunts (2018)
Journal Article
White, R., Parry, A., & Shales, C. (2018). Implications of shunt morphology for the surgical management of extrahepatic portosystemic shunts. Australian Veterinary Journal, 96(11), 433-441. https://doi.org/10.1111/avj.12756

Objectives: To describe the implications of extrahepatic portosystemic shunt morphology for 14 the chosen site of shunt closure in dogs and cats. Methods: A retrospective review of a consecutive series of dogs and cats managed for 16 congenital ext... Read More about Implications of shunt morphology for the surgical management of extrahepatic portosystemic shunts.

Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis (2018)
Journal Article
Probert, C., Dottorini, T., Speakman, A., Hunt, S., Nafee, T., Fazeli, A., …James, V. (2019). Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis. Oncogene, 38(10), 1751-1763. https://doi.org/10.1038/s41388-018-0540-5

© 2018, The Author(s). The role of extracellular vesicles (EVs) as vehicles for cell-to-cell communication between a tumour and its environment is a relatively new concept. The hypothesis that EVs may be critical in co-opting tissues by tumours to ge... Read More about Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis.

Associations between routinely collected dairy herd improvement data and insemination outcome in UK dairy herds (2018)
Journal Article
HUDSON, C., & GREEN, M. (2018). Associations between routinely collected dairy herd improvement data and insemination outcome in UK dairy herds. Journal of Dairy Science, 101(12), 11262-11274. https://doi.org/10.3168/jds.2017-13962

Milk constituent concentrations in samples taken during early lactation are often used to generate proxy measures for energy balance in dairy herds. This study aimed to explore associations between these and other measures routinely recorded by dairy... Read More about Associations between routinely collected dairy herd improvement data and insemination outcome in UK dairy herds.

Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging (2018)
Journal Article
Nizamudeen, Z., Markus, R., Lodge, R., Parmenter, C., Platt, M., Chakrabarti, L., & Sottile, V. (2018). Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865(12), 1891-1900. https://doi.org/10.1016/j.bbamcr.2018.09.008

Extracellular vesicles (EVs) have prevalent roles in cancer biology and regenerative medicine. Conventional techniques for characterising EVs including electron microscopy (EM), nanoparticle tracking analysis (NTA) and tuneable resistive pulse sensin... Read More about Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging.

A cross-sectional study of experiences and attitudes towards clinical audit of farm animal veterinary surgeons in the United Kingdom (2018)
Journal Article
Waine, K., Dean, R., Hudson, C., Huxley, J., & Brennan, M. L. (2018). A cross-sectional study of experiences and attitudes towards clinical audit of farm animal veterinary surgeons in the United Kingdom. Veterinary Sciences, 5(4), 84. https://doi.org/10.3390/vetsci5040084

© 2018 by the authors. Clinical audit is a quality improvement tool used to assess and improve the clinical services provided to patients. This is the first study to investigate the extent to which clinical audit is understood and utilised in farm an... Read More about A cross-sectional study of experiences and attitudes towards clinical audit of farm animal veterinary surgeons in the United Kingdom.

A survey to determine the farm level impact of Schmallenberg virus during the 2016-17 UK lambing season (2018)
Journal Article
Stokes, J. E., Tarlinton, R. E., Lovatt, F., Baylis, M., Carson, A., & Duncan, J. S. (2018). A survey to determine the farm level impact of Schmallenberg virus during the 2016-17 UK lambing season. Veterinary Record, https://doi.org/10.1136/vr.104866

Schmallenberg virus (SBV) causes abortions, still births and fetal malformations in naive ruminants. The impact of the initial outbreak (2011/2012) on British sheep farms has been previously investigated, with higher farmer perceived impacts and incr... Read More about A survey to determine the farm level impact of Schmallenberg virus during the 2016-17 UK lambing season.

Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using ?-XRF imaging and inductively coupled plasma mass spectrometry (2018)
Journal Article
Al-sandaqchi, A. T., Brignell, C., Collingwood, J. F., Geraki, K., Mirkes, E. M., Kong, K., …Elsheikha, H. M. (2018). Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using μ-XRF imaging and inductively coupled plasma mass spectrometry. Metallomics, 1401-1414. https://doi.org/10.1039/C8MT00136G

In this study, we measured the levels of elements in human brain microvascular endothelial cells (ECs) infected with T. gondii. ECs were infected with tachyzoites of the RH strain, and at 6, 24, and 48 hours post infection (hpi), the intracellular co... Read More about Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using ?-XRF imaging and inductively coupled plasma mass spectrometry.

Avian Cardiovascular Disease Characteristics, Causes and Genomics (2018)
Book Chapter
Kubale, V., Merry, K., Miller, G., Ruiz Diaz, M., & Rutland, C. (2018). Avian Cardiovascular Disease Characteristics, Causes and Genomics. In X. Liu (Ed.), Application of genetics and genomics in poultry science (141-162). London: InTech. https://doi.org/10.5772/intechopen.78005

Cardiovascular disease is common in avian species and increasing commercial economic losses and demand for healthcare in the household/smallholding veterinary sector has resulted in increased research into these disorders. This in turn has highlighte... Read More about Avian Cardiovascular Disease Characteristics, Causes and Genomics.

Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses (2018)
Journal Article
Kovac, M., Litvin, Y. A., Aliev, R. O., Zakirova, E. Y., Rutland, C. S., Kiyasov, A. P., & Rizvanov, A. A. (2018). Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses. Frontiers in Pharmacology, 9, https://doi.org/10.3389/fphar.2018.00978

This clinical study describes the intralesional application of the plasmid DNA encoding two therapeutic species-specific growth factors: vascular endothelial growth factor (VEGF164) and fibroblast growth factor 2 (FGF2) in seven horses to restore nat... Read More about Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses.

Prevalence of antibodies against Toxoplasma gondii in pets and their owners in Shandong province, Eastern China (2018)
Journal Article
Cong, W., Elsheikha, H. M., Zhou, N., Peng, P., Qin, S., Meng, Q., & Qian, A. (2018). Prevalence of antibodies against Toxoplasma gondii in pets and their owners in Shandong province, Eastern China. BMC Infectious Diseases, 18(1), Article 430. https://doi.org/10.1186/s12879-018-3307-2

Background: Pet ownership in China has been steadily increasing over recent years. However, the risk of pet-associated zoonotic infection with the protozoan parasite Toxoplasma gondii remains poorly defined. Methods: In a cross-sectional survey, we... Read More about Prevalence of antibodies against Toxoplasma gondii in pets and their owners in Shandong province, Eastern China.

Functional characterization of dense granule proteins in Toxoplasma gondii RH strain using CRISPR-Cas9 system (2018)
Journal Article
Bai, M., Wang, J., Elsheikha, H. M., Liang, Q., Chen, K., Nie, L., & Zhu, X. (2018). Functional characterization of dense granule proteins in Toxoplasma gondii RH strain using CRISPR-Cas9 system. Frontiers in Cellular and Infection Microbiology, 8, 1-9. https://doi.org/10.3389/fcimb.2018.00300

Infection with the apicomplexan protozoan parasite Toxoplasma gondii is an ongoing public health problem. The parasite's ability to invade and replicate within the host cell is dependent on many effectors, such as dense granule proteins (GRAs) releas... Read More about Functional characterization of dense granule proteins in Toxoplasma gondii RH strain using CRISPR-Cas9 system.

CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation (2018)
Journal Article
Quintero, C. M., Laursen, K. B., Mongan, N. P., Luo, M., & Gudas, L. J. (2018). CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation. Journal of Molecular Biology, 430(21), 4168-4182. https://doi.org/10.1016/j.jmb.2018.08.014

Activation of the retinoic acid (RA) signaling pathway is important for controlling embryonic stem cell differentiation and development. Modulation of this pathway occurs through the recruitment of different epigenetic regulators at the retinoic acid... Read More about CARM1 (PRMT4) acts as a transcriptional coactivator during retinoic acid-induced embryonic stem cell differentiation.

A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and to evaluate their suitability for the immobilisation of healthy chimpanzees (2018)
Journal Article
Strong, V., Möller, T., Tillman, A., Träff, S., Guevara, L., Martin, M., …White, K. (2018). A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and to evaluate their suitability for the immobilisation of healthy chimpanzees. Veterinary Anaesthesia and Analgesia, https://doi.org/10.1016/j.vaa.2018.06.015

Objective: To characterise the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and their suitability for the immobilisation of healthy chimpanzees undergoing cardiac assessment. Study de... Read More about A clinical study to evaluate the cardiopulmonary characteristics of two different anaesthetic protocols (tiletamine/zolazepam +/- medetomidine) and to evaluate their suitability for the immobilisation of healthy chimpanzees.

The role of PIP5K1?/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1? inhibitor (2018)
Journal Article
Sarwar, M., Syed Khaja, A. S., Aleskandarany, M., Karlsson, R., Althobiti, M., Ødum, N., …Persson, J. L. (2019). The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor. Oncogene, 38(3), 375-389. https://doi.org/10.1038/s41388-018-0438-2

© 2018, The Author(s). Despite recent improvement in adjuvant therapies, triple-negative, and ER + subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinosi... Read More about The role of PIP5K1?/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1? inhibitor.