All Outputs (3)

The use of decellularised animal tissue to study disseminating cancer cells (2018)
Journal Article
Grey, J. F. E., Campbell-Ritchie, A., Everitt, N. M., Fezovich, A. J., & Wheatley, S. P. (2019). The use of decellularised animal tissue to study disseminating cancer cells. Journal of Cell Science, 132(4), Article jcs219907. https://doi.org/10.1242/jcs.219907

Since the establishment of cell culture, common practice has been to grow adherent cells in 2D monolayers. Although cells behave completely differently when grown under these artificial conditions, the ease of 2D culturing has meant that this practic... Read More about The use of decellularised animal tissue to study disseminating cancer cells.

Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3 (2018)
Journal Article
Humphry, N. J., & Wheatley, S. P. (2018). Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3. Biology Open, 7(10), 037374. https://doi.org/10.1242/bio.037374

Survivin expression is pivotal to life and death at the cellular level. For the past decade its pro-survival activity has been attributed to its essential role in cell proliferation and its ability to inhibit apoptosis. However, a growing body of... Read More about Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3.

Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis (2018)
Journal Article
Wall, R. J., Ferguson, D. J. P., Freville, A., Franke-Fayard, B., Brady, D., Zeeshan, M., …Tewari, R. (in press). Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis. Scientific Reports, 8(1), Article 5610. https://doi.org/10.1038/s41598-018-23871-9

The anaphase promoting complex/cyclosome (APC/C) is a highly conserved multi-subunit E3 ubiquitin ligase that controls mitotic division in eukaryotic cells by tagging cell cycle regulators for proteolysis. APC3 is a key component that contributes to... Read More about Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.