Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial

Patel, Poulam M.; Ottensmeier, Christian H.; Mulatero, Clive; Lorigan, Paul; Plummer, Ruth; Pandha, Hardev S.; Elsheikh, Somaia; Hadjimichael, Efthymios; Villasanti, Naty; Cunnell, Michelle; Metheringham, Rachael L.; Brentville, Victoria A.; Machado, Lee; Daniels, Ian; Gijon, Mohamed; Hannaman, Drew; Durrant, Lindy

doi:10.1080/2162402X.2018.1433516

All Outputs (2)

Vestibulotoxicity associated with platinum-based chemotherapy in survivors of cancer: a scoping review (2018)
Journal Article
Prayuenyong, P., Taylor, J. A., Pearson, S. E., Gomez, R., Patel, P. M., Hall, D. A., …Baguley, D. M. (2018). Vestibulotoxicity associated with platinum-based chemotherapy in survivors of cancer: a scoping review. Frontiers in Oncology, 8, Article 363. https://doi.org/10.3389/fonc.2018.00363

Background: Cochleotoxicity following the treatment with platinum-based chemotherapy is well documented. The potential for vestibulotoxicity is still unclear. This scoping review examined the extent of current research literature, summarized research... Read More about Vestibulotoxicity associated with platinum-based chemotherapy in survivors of cancer: a scoping review.

Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial (2018)
Journal Article
Patel, P. M., Ottensmeier, C. H., Mulatero, C., Lorigan, P., Plummer, R., Pandha, H. S., …Durrant, L. (2018). Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial. OncoImmunology, 7(6), Article e1433516. https://doi.org/10.1080/2162402X.2018.1433516

A DNA vaccine, SCIB1, incorporating two CD8 and two CD4 epitopes from TRP-2/gp100 was evaluated in patients with metastatic melanoma. Each patient received SCIB1 via intramuscular injection with electroporation. The trial was designed to find the saf... Read More about Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial.