Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases
(2018)
Journal Article
Jenner, M., Kosol, S., Griffiths, D., Prasongpholchai, P., Manzi, L., Barrow, A. S., …Challis, G. (2018). Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases. Nature Chemical Biology, 14, 270-275. https://doi.org/10.1038/nchembio.2549
Modular polyketide synthases (PKSs) produce numerous structurally complex natural products with diverse applications in medicine and agriculture. They typically consist of several multienzyme subunits that utilize structurally-defined docking domains... Read More about Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases.