NICE guidance on sepsis is of limited value in postoperative colorectal patients: the scores that cry ‘wolf!’

Herrod, P.J.J.; Cox, M.; Keevil, H.; Smith, KJE; Lund, J. N.

doi:10.1308/rcsann.2017.0227

The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females (2018)
Journal Article
Herrod, P. J. J., Blackwell, J. E. M., Moss, B. F., Gates, A., Atherton, P. J., Lund, J. N., …Phillips, B. E. (2019). The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females. European Journal of Applied Physiology, 119(3), 645-652. https://doi.org/10.1007/s00421-018-4054-1

PURPOSE: Cardiovascular disease (CVD) is the leading cause of death worldwide. Many risk factors for CVD can be modified pharmacologically; however, uptake of medications is low, especially in asymptomatic people. Exercise is also effective at reduc... Read More about The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females.

Pre‐emptive and preventive opioids for postoperative pain in adults undergoing all types of surgery (2018)
Journal Article
Doleman, B., Leonardi-Bee, J., Lund, J. N., Heinink, T. P., Bhattacharjee, D., & Williams, J. P. (2018). Pre‐emptive and preventive opioids for postoperative pain in adults undergoing all types of surgery. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD012624.pub2

Background: Postoperative pain is a common consequence of surgery and can have deleterious effects. It has been suggested that the administration of opioid analgesia before a painful stimulus may improve pain control. This can be done in two ways. We... Read More about Pre‐emptive and preventive opioids for postoperative pain in adults undergoing all types of surgery.

Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease (2018)
Journal Article
Sian, T. S., Herrod, P. J. J., Blackwell, J. E. M., Hardy, E. J. O., & Lund, J. N. (2018). Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease. Techniques in Coloproctology, 22(10), 779-784. https://doi.org/10.1007/s10151-018-1864-4

Background Pilonidal sinus disease (PSD) is a common, chronic inflammatory condition involving hair follicles within the natal cleft. It mainly affects young males and creates a significant health, social and economic burden. Traditional surgery i... Read More about Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease.

‘Blood in pee’ campaign: Increased demand on secondary care with no change in cancers diagnosed (2018)
Journal Article
Patel, K., Hall, S. J., Shraddha, K., Stanford, R., Williams, S., & Lund, J. (2019). ‘Blood in pee’ campaign: Increased demand on secondary care with no change in cancers diagnosed. Journal of Clinical Urology, 12(1), 15-19. https://doi.org/10.1177/2051415818801187

Objective: As part of the national Be Clear on Cancer campaign, the ‘blood in pee’ campaign was launched in 2013. We aimed to evaluate the impact of the campaign on 2-week wait (2WW) referrals and the resulting diagnoses of malignancy at a single tr... Read More about ‘Blood in pee’ campaign: Increased demand on secondary care with no change in cancers diagnosed.

Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children (2018)
Journal Article
Hardy, E., Herrod, P., Sian, T., Boyd-Carson, H., Blackwell, J., Lund, J., & Quarmby, J. (2019). Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children. Journal of Pediatric Surgery, 54(8), 1668-1670. https://doi.org/10.1016/j.jpedsurg.2018.07.024

Background / Purpose: Sacrococcygeal pilonidal sinus disease (PSD) has an incidence of 1.2–2.5/1000 in children. Onset is around puberty. Symptoms of recurrent abscess and chronic suppuration may interfere with education and social integration. Treat... Read More about Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children.

Short-term (less 8 wk) high-intensity interval training in diseased cohorts (2018)
Journal Article
Blackwell, J. E., Doleman, B., Herrod, P., Ricketts, S., Phillips, B. E., Lund, J. N., & Williams, J. P. (2018). Short-term (less 8 wk) high-intensity interval training in diseased cohorts. Medicine and Science in Sports and Exercise, 50(9), 1740–1749. https://doi.org/10.1249/MSS.0000000000001634

Background and Aim: Exercise training regimes can lead to improvements in measures of cardiorespiratory fitness (CRF), improved general health, and reduced morbidity and overall mortality risk. High-intensity interval training (HIIT) offers a time-ef... Read More about Short-term (less 8 wk) high-intensity interval training in diseased cohorts.

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study (2018)
Journal Article
STARSurg Collaborative. (2018). Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study. BJS Open, 2(6), 400-410. https://doi.org/10.1002/bjs5.86

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a... Read More about Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study (2018)
Journal Article
STARSurg Collaborative. (2018). Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study. Anaesthesia, 73(10), 1214-1222. https://doi.org/10.1111/anae.14349

The peri‐operative use of angiotensin‐converting enzyme inhibitors or angiotensin‐2 receptor blockers is thought to be associated with an increased risk of postoperative acute kidney injury. To reduce this risk, these agents are commonly withheld dur... Read More about Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study.

Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study (2018)
Journal Article
GlobalSurg Collaborative. (2018). Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study. Surgical Endoscopy, 32(8), 3450-3466. https://doi.org/10.1007/s00464-018-6064-9

BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described... Read More about Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

The use of cannabinoids in colitis: a systematic review and meta-analysis (2018)
Journal Article
Couch, D. G., Maudslay, H., Doleman, B., Lund, J. N., & O'Sullivan, S. (2018). The use of cannabinoids in colitis: a systematic review and meta-analysis. Inflammatory Bowel Diseases, 24(4), 680-697. https://doi.org/10.1093/ibd/izy014

Background: Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation. Methods: We systematically revie... Read More about The use of cannabinoids in colitis: a systematic review and meta-analysis.

Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol) (2018)
Journal Article
Doleman, B., Leonardi-Bee, J., Heinink, T. P., Lund, J., & Williams, J. P. (2018). Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol). Cochrane Database of Systematic Reviews, 3, https://doi.org/10.1002/14651858.CD012978

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate in adult participants undergoing all types of surgery, the effects of pre-emptive and preventive non-steroidal anti-inflammatory drugs (NSAIDs) com... Read More about Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol).

A multicentre integration of a computer-led follow-up of prostate cancer is valid and safe (2018)
Journal Article
Salem, H. A., Salem, H. A., Caddeo, G., McFarlane, J., Patel, K., Cochrane, L., …Lund, J. (2018). A multicentre integration of a computer-led follow-up of prostate cancer is valid and safe. BJU International, 122(3), 418-426. https://doi.org/10.1111/bju.14157

© 2018 The Authors BJU International published by John Wiley & Sons Ltd on behalf of BJU International Objective: To test a computer-led follow-up service for prostate cancer in two UK hospitals; the testing aimed to validate the computer expert sy... Read More about A multicentre integration of a computer-led follow-up of prostate cancer is valid and safe.

Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway (2018)
Journal Article
Herrod, P., & Lund, J. N. (in press). Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway. Techniques in Coloproctology, 22(2), https://doi.org/10.1007/s10151-018-1756-7

Background: Random duodenal biopsy to exclude coeliac disease during upper gastrointestinal endoscopy for the investigation of iron defciency anaemia remains a common procedure, but is expensive and time-consuming. Serological investigation for coeli... Read More about Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway.

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study (2018)
Journal Article
Lund, J., Muntean, L., Roszkowski, R., Sandu Mironescu, A., Zaa'treh, R., Corneliu Vida, L., …Elkhalek Sallam, A. (2018). Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infectious Diseases, 18(5), 516-525. https://doi.org/10.1016/S1473-3099%2818%2930101-4

Exercise and other nonpharmacological strategies to reduce blood pressure in older adults: a systematic review and meta-analysis (2018)
Journal Article
Herrod, P. J., Doleman, B., Blackwell, J. E., O’Boyle, F., Williams, J. P., Lund, J. N., & Phillips, B. E. (in press). Exercise and other nonpharmacological strategies to reduce blood pressure in older adults: a systematic review and meta-analysis. Journal of the American Society of Hypertension, 12(4), https://doi.org/10.1016/j.jash.2018.01.008

The incidence of hypertension increases with advancing age and represents a significant burden of disease. Lifestyle modification represents the first-line intervention in treatment algorithms; however, the majority of evidence for this comes from st... Read More about Exercise and other nonpharmacological strategies to reduce blood pressure in older adults: a systematic review and meta-analysis.

NICE guidance on sepsis is of limited value in postoperative colorectal patients: the scores that cry ‘wolf!’ (2018)
Journal Article
Herrod, P., Cox, M., Keevil, H., Smith, K., & Lund, J. N. (2018). NICE guidance on sepsis is of limited value in postoperative colorectal patients: the scores that cry ‘wolf!’. Annals of The Royal College of Surgeons of England, 100(4), 275-278. https://doi.org/10.1308/rcsann.2017.0227

Background and aims Late recognition of sepsis and consequent death remains a problem. To address this, the National Institute for Health and Care Excellence has published updated guidance recommending the use of the Quick Sequential Organ Failure A... Read More about NICE guidance on sepsis is of limited value in postoperative colorectal patients: the scores that cry ‘wolf!’.

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