All Outputs (2)

Rational design of thermostable carbonic anhydrase mutants using molecular dynamics simulations (2018)
Journal Article
Parra-Cruz, R., Jäger, C. M., Lau, P. L., Gomes, R. L., & Pordea, A. (2018). Rational design of thermostable carbonic anhydrase mutants using molecular dynamics simulations. Journal of Physical Chemistry B, 122(36), 8526-8536. https://doi.org/10.1021/acs.jpcb.8b05926

The stability of enzymes is critical for their application in industrial processes, which generally require different conditions from the natural enzyme environment. Both rational and random protein engineering approaches have been used to increase s... Read More about Rational design of thermostable carbonic anhydrase mutants using molecular dynamics simulations.

Biocatalyst-artificial metalloenzyme cascade based on alcohol dehydrogenase (2018)
Journal Article
Morra, S., & Pordea, A. (2018). Biocatalyst-artificial metalloenzyme cascade based on alcohol dehydrogenase. Chemical Science, 9(38), 7447-7454. https://doi.org/10.1039/C8SC02371A

© The Royal Society of Chemistry. Chemo-enzymatic cascades of enzymes with transition metal catalysts can offer efficient synthetic strategies, but their development is challenging due to the incompatibility between proteins and transition metal comp... Read More about Biocatalyst-artificial metalloenzyme cascade based on alcohol dehydrogenase.