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All Outputs (4)

TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations (2018)
Journal Article
Mallia-Milanes, B., Dufour, A., Philp, C., Solis, N., Klein, T., Fischer, M., …Johnson, S. R. (2018). TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations. AJP - Lung Cellular and Molecular Physiology, 315(6), L1003-L1014. https://doi.org/10.1152/ajplung.00175.2018

© 2018 the American Physiological Society. Dys-regulated protease activity is thought to cause parenchymal and airway damage in chronic obstructive pulmonary disease (COPD). Multiple proteases have been implicated in COPD, and identifying their subst... Read More about TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations.

The vitamin D binding protein axis modifies disease severity in lymphangioleiomyomatosis (2018)
Journal Article
Miller, S., Coveney, C., Johnson, J., Farmaki, A. E., Gupta, N., Tobin, M. D., …Johnson, S. R. (2018). The vitamin D binding protein axis modifies disease severity in lymphangioleiomyomatosis. European Respiratory Journal, 52(5), Article 1801074. https://doi.org/10.1183/13993003.00951-2018

Background: Lymphangioleiomyomatosis (LAM) is a rare disease of women. Decline in lung function is variable making appropriate targeting of therapy difficult. We used unbiased serum proteomics to identify markers associated with outcome in LAM. Meth... Read More about The vitamin D binding protein axis modifies disease severity in lymphangioleiomyomatosis.

Endocrine therapy for breast cancer: a model of hormonal manipulation (2018)
Journal Article
Johnston, S. J., & Cheung, K. (in press). Endocrine therapy for breast cancer: a model of hormonal manipulation. Oncology and Therapy, https://doi.org/10.1007/s40487-018-0062-x

Oestrogen receptor (ER) is the driving transcription factor in 70% of breast cancer. Endocrine therapies targeting the ER represent one of the most successful anticancer strategies to date. In the clinic, novel targeted agents are now being exploited... Read More about Endocrine therapy for breast cancer: a model of hormonal manipulation.

A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling (2018)
Journal Article
Hill, M., Philp, C. J., Billington, C. K., Tatler, A. L., Johnson, S. R., O'Dea, R. D., & Brook, B. S. (2018). A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling. Biomechanics and Modeling in Mechanobiology, 17(5), 1451-1470. https://doi.org/10.1007/s10237-018-1037-4

© 2018, The Author(s). Inflammation, airway hyper-responsiveness and airway remodelling are well-established hallmarks of asthma, but their inter-relationships remain elusive. In order to obtain a better understanding of their inter-dependence, we de... Read More about A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling.