Skip to main content

Research Repository

Advanced Search

All Outputs (3)

Bovine neonatal monocytes display phenotypic differences compared with adults after challenge with the infectious abortifacient agent Neospora caninum (2018)
Journal Article
Sharma, P., Hartley, C. S., Haque, M., Coffey, T. J., Egan, S. A., & Flynn, R. J. (2018). Bovine neonatal monocytes display phenotypic differences compared with adults after challenge with the infectious abortifacient agent Neospora caninum. Frontiers in Immunology, 9, Article 3011. https://doi.org/10.3389/fimmu.2018.03011

The neonatal period represents a window of susceptibility for ruminants given the abundance of infectious challenges in their environment. Maternal transfer of immunity does not occur in utero but post-parturition, however this does not compensate fo... Read More about Bovine neonatal monocytes display phenotypic differences compared with adults after challenge with the infectious abortifacient agent Neospora caninum.

Macrophage-derived IL-1? and TNF-? regulate arginine metabolism in neuroblastoma (2018)
Journal Article
Burchill, S. A., Ziegler, D. S., Etchevers, H. C., Norris, M. D., Cheng, P. N., McConville, C. M., …Mussai, F. (2019). Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma. Cancer Research, 79(3), 611-624. https://doi.org/10.1158/0008-5472.CAN-18-2139

© 2018 American Association for Cancer Research. Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regu... Read More about Macrophage-derived IL-1? and TNF-? regulate arginine metabolism in neuroblastoma.

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma (2018)
Journal Article
De Santo, C., Cheng, P., Beggs, A., Egan, S., Bessudo, A., & Mussai, F. (2018). Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma. Journal of Hematology and Oncology, 11, Article 68. https://doi.org/10.1186/s13045-018-0612-6

Background Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 ant... Read More about Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma.