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All Outputs (6)

A systematic review on the pharmacokinetics of cannabidiol in humans (2018)
Journal Article
Millar, S. A., Stone, N. L., Yates, A. S., & O 'Sullivan, S. E. (2018). A systematic review on the pharmacokinetics of cannabidiol in humans. Frontiers in Pharmacology, 9, 1-13

Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this review was to colla... Read More about A systematic review on the pharmacokinetics of cannabidiol in humans.

An analysis of endocannabinoid concentrations and mood following singing and exercise in healthy volunteers (2018)
Journal Article
Stone, N. L., Millar, S. A., Herrod, P. J. J., Barrett, D. A., Ortori, C. A., Mellon, V. A., & O’Sullivan, S. E. (2018). An analysis of endocannabinoid concentrations and mood following singing and exercise in healthy volunteers. Frontiers in Behavioral Neuroscience, 12, 1-10. https://doi.org/10.3389/fnbeh.2018.00269

© 2018 Stone, Millar, Herrod, Barrett, Ortori, Mellon and O’Sullivan. The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids (eCBs). eCBs are lipid signaling molecules involved in reward, appe... Read More about An analysis of endocannabinoid concentrations and mood following singing and exercise in healthy volunteers.

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes (2018)
Journal Article
Doris, J. M., Millar, S. A., Idris, I., & O'Sullivan, S. E. (2019). Genetic polymorphisms of the endocannabinoid system in obesity and diabetes. Diabetes, Obesity and Metabolism, 21(2), 382-387. https://doi.org/10.1111/dom.13504

The endocannabinoid system (ECS) is involved in many physiological processes including fertility, pain and energy regulation. The aim of this systematic review was to examine the contribution of single nucleotide polymorphisms (SNPs) of the ECS to ad... Read More about Genetic polymorphisms of the endocannabinoid system in obesity and diabetes.

Serum amyloid protein is associated with outcome following acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial (RECAST) (2018)
Conference Proceeding
Appleton, J. P., Hedstrom, A., O'Sullivan, S., May, J., Sprigg, N., Bath, P. M., & England, T. J. (2018). Serum amyloid protein is associated with outcome following acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial (RECAST).

Background: Remote ischaemic per-conditioning (RIC) in experimental ischaemic stroke is neuroprotective. Several neurohumoral, vascular and inflammatory mediators are implicated. Methods: The REmote ischaemic Conditioning After Stroke Trial (RECAS... Read More about Serum amyloid protein is associated with outcome following acute ischaemic stroke: data from the REmote ischaemic Conditioning After Stroke Trial (RECAST).

The use of cannabinoids in colitis: a systematic review and meta-analysis (2018)
Journal Article
Couch, D. G., Maudslay, H., Doleman, B., Lund, J. N., & O'Sullivan, S. (2018). The use of cannabinoids in colitis: a systematic review and meta-analysis. Inflammatory Bowel Diseases, 24(4), 680-697. https://doi.org/10.1093/ibd/izy014

Background: Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation. Methods: We systematically revie... Read More about The use of cannabinoids in colitis: a systematic review and meta-analysis.

A systematic review and meta-analysis of the in vivo haemodynamic effects of ?9-Tetrahydrocannabinol (2018)
Journal Article
Sultan, S. R., Millar, S. A., O’Sullivan, S. E., & England, T. J. (2018). A systematic review and meta-analysis of the in vivo haemodynamic effects of Δ9-Tetrahydrocannabinol. Pharmaceuticals, 11(1), Article 13. https://doi.org/10.3390/ph11010013

?9-Tetrahydrocannabinol (THC) has complex effects on the cardiovascular system. We aimed to systematically review studies of THC and haemodynamic alterations. PubMed, Medline, and EMBASE were searched for relevant studies. Changes in blood pressure (... Read More about A systematic review and meta-analysis of the in vivo haemodynamic effects of ?9-Tetrahydrocannabinol.