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All Outputs (2)

Strategy for tumor selective disruption of androgen receptor function in the spectrum of prostate cancer (2018)
Journal Article
Rosati, R., Polin, L. A., Ducker, C., Li, J., Bao, X., Selvakumar, D., …Ratnam, M. (2018). Strategy for tumor selective disruption of androgen receptor function in the spectrum of prostate cancer. Clinical Cancer Research, https://doi.org/10.1158/1078-0432.ccr-18-0982

Purpose: Testosterone suppression in prostate cancer (PC) is limited by serious side effects and resistance via restoration of androgen receptor (AR) functionality. ELK1 is required for ARdependent growth in various hormone-dependent and castration r... Read More about Strategy for tumor selective disruption of androgen receptor function in the spectrum of prostate cancer.

A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia (2018)
Journal Article
Foxler, D. E., Bridge, K. S., Foster, J. G., Grevitt, P., Curry, S., Shah, K. M., …Sharp, T. V. (in press). A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. EMBO Molecular Medicine, Article e8304. https://doi.org/10.15252/emmm.201708304

The adaptive cellular response to low oxygen tensions is mediated by the hypoxia inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and β subunits. Prolonged HIF expression is a key contributor to cellular t... Read More about A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.