Biased agonism in drug discovery: is it too soon to choose a path?
(2018)
Journal Article
Michel, M. C., & Charlton, S. J. (2018). Biased agonism in drug discovery: is it too soon to choose a path?. Molecular Pharmacology, 93(4), https://doi.org/10.1124/mol.117.110890
A single receptor can activate multiple signaling pathways that have distinct or even opposite effects on cell function. Biased agonists stabilize receptor conformations preferentially stimulating one of these pathways, and therefore allow a more tar... Read More about Biased agonism in drug discovery: is it too soon to choose a path?.