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An ensemble code in medial prefrontal cortex links prior events to outcomes during learning (2018)
Journal Article
Maggi, S., Peyrache, A., & Humphries, M. D. (2018). An ensemble code in medial prefrontal cortex links prior events to outcomes during learning. Nature Communications, 9(1), Article 2204. https://doi.org/10.1038/s41467-018-04638-2

The prefrontal cortex is implicated in learning the rules of an environment through trial and error. But it is unclear how such learning is related to the prefrontal cortex’s role in short-term memory. Here we ask if the encoding of short-term memory... Read More about An ensemble code in medial prefrontal cortex links prior events to outcomes during learning.

Insights into Parkinson’s disease from computational models of the basal ganglia (2018)
Journal Article
Humphries, M. D., Obeso, J. A., & Dreyer, J. K. (2018). Insights into Parkinson’s disease from computational models of the basal ganglia. Journal of Neurology, Neurosurgery and Psychiatry, https://doi.org/10.1136/jnnp-2017-315922

Movement disorders arise from the complex interplay of multiple changes to neural circuits. Successful treatments for these disorders could interact with these complex changes in myriad ways, and as a consequence their mechanisms of action and their... Read More about Insights into Parkinson’s disease from computational models of the basal ganglia.

A probabilistic, distributed, recursive mechanism for decision-making in the brain (2018)
Journal Article
Caballero, J. A., Humphries, M. D., & Gurney, K. N. (2018). A probabilistic, distributed, recursive mechanism for decision-making in the brain. PLoS Computational Biology, 14(4), Article e1006033. https://doi.org/10.1371/journal.pcbi.1006033

Decision formation recruits many brain regions, but the procedure they jointly execute is unknown. Here we characterize its essential composition, using as a framework a novel recursive Bayesian algorithm that makes decisions based on spike-trains wi... Read More about A probabilistic, distributed, recursive mechanism for decision-making in the brain.