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CX-4945 induces methuosis in cholangiocarcinoma cell lines by a CK2-independent mechanism (2018)
Journal Article
Lertsuwan, J., Lertsuwan, K., Sawasdichai, A., Tasnawijitwong, N., Lee, K., Kitchen, P., …Satayavivad, J. (2018). CX-4945 induces methuosis in cholangiocarcinoma cell lines by a CK2-independent mechanism. Cancers, 10(9), Article 283. https://doi.org/10.3390/cancers10090283

Cholangiocarcinoma is a disease with a poor prognosis and increasing incidence and hence there is a pressing unmet clinical need for new adjuvant treatments. Protein kinase CK2 (previously casein kinase II) is a ubiquitously expressed protein kinase... Read More about CX-4945 induces methuosis in cholangiocarcinoma cell lines by a CK2-independent mechanism.

Phosphorylation of PRH/HHEX by Protein Kinase CK2 regulates cell proliferation and cell migration in diverse cell types (2018)
Book Chapter
Jayaraman, P., Wadey, K., George, S., & Gaston, K. (2018). Phosphorylation of PRH/HHEX by Protein Kinase CK2 regulates cell proliferation and cell migration in diverse cell types. In F. Uchiumi (Ed.), Gene expression and regulation in mammalian cells (237--255). InTech. https://doi.org/10.5772/intechopen.72902

Disruption of the regulatory mechanisms that control cell proliferation and cell migration results in multiple disease states including cancer and leukemia. The Proline-Rich Homeodomain protein (PRH)/haematopoietically expressed homeobox protein (HHE... Read More about Phosphorylation of PRH/HHEX by Protein Kinase CK2 regulates cell proliferation and cell migration in diverse cell types.